Homocysteine in CAD patients-Does it matter?

Authors

  • Sowndarya K.
  • Arpit Jain
  • Ramya Shenoy
  • Padmanabh Kamath K.
  • Anupama Hegde

DOI:

https://doi.org/10.51248/.v42i5.1962

Keywords:

Coronary artery disease, Dyslipidemia, Homocysteine

Abstract

Introduction and Aim: Homocysteine (Hcy) is considered as an independent risk factor for coronary artery disease (CAD). Hyperhomocysteinemia (HHcy) may be caused due to the deficiency of vitamin B12, folic acid (FA), and pyridoxine (B6) or due to genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR). A pilot study was undertaken to investigate Hcy levels and its association with lipid profile in patients with CAD.

 

Methods: Lipid profile values were obtained from laboratory reports and the Hcy levels were estimated by enzymatic cycling assay using the commercial kits in autoanalyzer in subjects with CAD (n=12).

 

Results: Hcy (14.58 ± 8.32 µmol/L), LDL (134.75 ± 45.02 mg/dl) and non-HDL (150.25 ± 56.89 mg/dl) levels were found to be elevated in patients with CAD.

 

Conclusion: Dyslipidemia was associated with variable Hcy levels. Few patients with HHcy showed concurrent upsurge in LDL and non-HDL levels.

Author Biographies

Sowndarya K.

Department of Biochemistry, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India

Arpit Jain

Department of Cardiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India

Ramya Shenoy

Department of Public Health Dentistry, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India

Padmanabh Kamath K.

Department of Cardiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, Indi

Anupama Hegde

Department of Biochemistry, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India

References

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Published

2022-11-14

How to Cite

1.
K. S, Jain A, Shenoy R, Kamath K. P, Hegde A. Homocysteine in CAD patients-Does it matter?. Biomedicine [Internet]. 2022 Nov. 14 [cited 2022 Nov. 27];42(5):1088-90. Available from: https://biomedicineonline.org/home/article/view/1962

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