The ABC (HbA1c, blood pressure and LDL-cholesterol) of diabetes and oxidative stress: knowing the links

Authors

  • Shreelaxmi V. Hegde
  • Prabha Adhikari
  • Shashidhar M. Kotian
  • Poornima Manjrekar
  • Rajeshwari Shastry
  • Vivian D’Souza

DOI:

https://doi.org/10.51248/.v42i5.2006

Keywords:

HbA1c, blood pressure, ; LDL-cholesterol, type 2 diabetes mellitus, oxidative stress

Abstract

Introduction and Aim: Large body of evidence suggests that oxidative stress has a crucial role to play in diabetes and its related complications. In the present research we have tried to determine potential risk factors for oxidative stress in type 2 diabetes by conducting a cross-sectional study.

 

Materials and Methods: We studied 238 patients with or without complications of diabetes, aged 40-75 years. Blood samples were analysed for fasting plasma glucose, glycated haemoglobin, malondialdehyde, total cholesterol, triglyceride, LDL-cholesterol and HDL-cholesterol. Each patient’s waist circumference, BMI, blood pressure was measured.

 

Results: Participants mean age was 57.5 ± 8.9 years. Logistic regression analysis identified glycated haemoglobin (95% CI: 1.02-1.92; p=0.04), hypertension (95% CI: 0.99-4.08; p=0.05) and LDL-cholesterol (95% CI: 1.12-5.87; p=0.03) as independent risk factors for oxidative stress. Other contributors were age and presence of complications like nephropathy, retinopathy, peripheral neuropathy and macrovascular disease in diabetes.

 

Conclusion: Our data demonstrate that ‘ABCs of diabetes’ namely HbA1c, blood pressure and LDL-cholesterol are independent risk factors for oxidative stress. Oxidative stress aggravates with age and presence of complications. It appears important to achieve a good ABC goal to bring down oxidative stress in diabetes.

Author Biographies

Shreelaxmi V. Hegde

Department of Biochemistry, Srinivas Institute of Medical Science and Research Centre, Mangalore; Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka, India

Prabha Adhikari

Department of Geriatric Medicine, Yenepoya Medical College, Yenepoya Deemed to be University, Mangalore, Karnataka, India

Shashidhar M. Kotian

Department of Research, Srinivas Institute of Medical Science and Research Centre, Mangalore; Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka, India

Poornima Manjrekar

Department of Biochemistry, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India

Rajeshwari Shastry

Department of Pharmacology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India

Vivian D’Souza

Department of Biochemistry, Kanachur Institute of Medical Sciences, Mangalore; Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka, India

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Published

2022-11-14

How to Cite

1.
V. Hegde S, Adhikari P, M. Kotian S, Manjrekar P, Shastry R, D’Souza V. The ABC (HbA1c, blood pressure and LDL-cholesterol) of diabetes and oxidative stress: knowing the links. Biomedicine [Internet]. 2022 Nov. 14 [cited 2022 Nov. 27];42(5):925-8. Available from: https://biomedicineonline.org/home/article/view/2006

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