Expression of autophagy and apoptosis biomarkers in patients with acute ischemic stroke

Authors

  • Mitalip Mamytov
  • Elmira Mamytova
  • Anara Toktomametova
  • Danil Miklukhin
  • Vityala Yethindra
  • Tugolbai Tagaev
  • Sandhya Kalikiri
  • Krishna Priya Kanteti

DOI:

https://doi.org/10.51248/.v42i5.2091

Keywords:

apoptosis, autophagy, acute ischemic stroke, annexin A5, caspase-3

Abstract

Introduction and Aim: Apoptosis, autophagy, and necrosis are the main mechanisms of neuron death in acute ischemic stroke (AIS). This study aimed to evaluate the expression of apoptosis and autophagy biomarkers in peripheral blood of patients with AIS.

 

Materials and Methods: Sixty-eight patients (32 men and 36 women) aged 30-60 years with AIS underwent a clinical and neurological examination on the 1st, 7th, and 14th days after the disease onset. The expression of apoptosis and autophagy biomarkers in peripheral blood was evaluated by flow cytometry and compared with the severity of neurological deficit and injury on the 1st, 7th, and 14th days, using correlation analysis.

 

Results: There is a statistical significance compared with the control group and an increase in the expression of key biomarkers of apoptosis and autophagy was revealed. Increased expression levels of annexin A5 and caspase-3 positively correlate with the severity of neurological deficit and injury on the 1st and 7th days from the onset of the disease.

 

Conclusion: A direct correlation was revealed between elevated levels of apoptosis and autophagy biomarkers in peripheral blood and severity of neurological deficit and injury on the 1st, 7th, and 14th days from the onset of AIS.

Author Biographies

Mitalip Mamytov

Department of Neurosurgery of undergraduate and postgraduate study, I. K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan

Elmira Mamytova

Department of Neurology and Clinical Genetics named after academician A. M. Murzaliev, I. K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan

Anara Toktomametova

Department of Neurology and Clinical Genetics named after academician A. M. Murzaliev, I. K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan

Danil Miklukhin

I. K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan

Vityala Yethindra

Department of Pathology, International Higher School of Medicine, International University of Kyrgyzstan, Bishkek, Kyrgyzstan

Tugolbai Tagaev

Department of Public Health and Healthcare, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan

Sandhya Kalikiri

Sri Venkateswara Institute of Medical Sciences-Sri Padmavathi Medical College for Women, Tirupati, Andhra Pradesh, India

Krishna Priya Kanteti

Gandhi Medical College and Hospital, Secunderabad, Telangana, India

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Published

2022-11-14

How to Cite

1.
Mamytov M, Mamytova E, Toktomametova A, Miklukhin D, Yethindra V, Tagaev T, Kalikiri S, Kanteti KP. Expression of autophagy and apoptosis biomarkers in patients with acute ischemic stroke. Biomedicine [Internet]. 2022 Nov. 14 [cited 2022 Nov. 27];42(5):988-91. Available from: https://biomedicineonline.org/home/article/view/2091

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