Assessing the potential correlation of polymorphisms in the TMPRSS2 gene with severity of COVID 19 patients


  • Nazar Zaki Mahdi
  • Anfal Mohammed Khudhair
  • Nawar Sahib Khalil



COVID 19, Gene polymorphism, SARS-CoV-2, TMPRSS2, SNPs


Introduction and Aim: Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Once infected this virus induces several clinical disorders in humans. SARSCoV-2 enters cells via TMPRSS2. Genetic variation in TMPRSS2 could affect the severity of infection. The purpose of this study was to investigate how the (TMPRSS2) gene polymorphism affected COVID-19 severity in patients as well as the effect of age and comorbidities on infection.


Materials and Methods: This cross-sectional analytical study comprised of 400 (185 male, 215 female) Covid-19-infected patients between ages 18-65 receiving treatment in hospitals at Baghdad, Iraq. The patients were divided into three groups: mild, moderate, and severe based on the severity of Covid-19 infection. Baseline data was collected for each patient through interview and questionnaire. Blood collected from patients was subjected to DNA extraction and detecting polymorphisms within SNPs of the TMPRSS2 gene.


Results: The present investigation indicated higher age to be significantly associated with severe COVID-19 infection when compared to moderate and mild infection (36.14 ± 12.716 vs. 48.52 ± 17.513 vs. 59.26 ± 16.035) (F= 3.697, df: 64, P= 0.000). Patients with comorbidities was associated with a greater rate of severe Covid-19 infection (74.2% vs. 25.8%). However, individuals without comorbidities had a considerably lower rate of mild and moderate Covid-19 infection (13.9% vs. 86.1%) and (36% vs. 64%), respectively (x^2: 97.930, df: 2, P = 0.000). SNPs; (rs383510, rs12329760) within the transmembrane TMPRSS2–7113 was studied and we found no  significant (P> 0.05) association for these SNPs to severity of Covid-19 infection.


Conclusion: The results show that the allelic variation within the TMPRSS2 (SNP rs2070788) gene to be linked to increasing illness severity in COVID-19 patients.

Author Biographies

Nazar Zaki Mahdi

Al-Karkh Health Department, Al- Karkh General Hospital, Baghdad, Iraq

Anfal Mohammed Khudhair

Department of Microbiology, College of Medicine, Al-Iraqi University, Baghdad, Adhamiyah, Iraq

Nawar Sahib Khalil

Department of Family and Community Medicine, College of Medicine, Al-Iraqia University, Baghdad, Iraq


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How to Cite

Zaki Mahdi N, Khudhair AM, Sahib Khalil N. Assessing the potential correlation of polymorphisms in the TMPRSS2 gene with severity of COVID 19 patients. Biomedicine [Internet]. 2022 Nov. 14 [cited 2022 Nov. 27];42(5):1034-9. Available from:



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