A doppler ultrasonographic observation of interventional postural alterations on shear rates in peripheral arteries





Shear rate, Blood flow velocity, Peripheral artery diameter, Atherosclerosis, Haemodynamic Shear Stress


Introduction and Aim: Drastic life style changes had resulted in increased reports of morbid atherosclerosis in young adults which is potentially a serious inflammatory condition which causes arteries to become harder and blocked with lipid accumulation known as plaques or atheroma. In the present study, effect of changes in posture on the resting shear rate (SR) was studied in arteries of both extremities.


Materials and Methods: A cross sectional observational doppler ultrasound study was done in 30 healthy subjects, who satisfied a pre-set inclusion and exclusion criteria. The mean blood flow velocity (BV) and diameter were measured for both brachial arteries and femoral arteries in supine, sitting with leg fully extended, sitting with leg flexed at 90o, standing with and without slight head tilting of 10o postures after resting the subjects for 10 minutes in between each posture. The SR in various postures were calculated and tabulated. The data was statistically analysed using independent ‘t’ test and one-way ANOVA. Post Hoc test was applied for analysing statistical significance of SR in between postures.


Results: The femoral artery showed significantly lower SR (P<0.001) in all the postures studied when compared to brachial artery. On comparing posture within brachial and femoral artery by applying one-way ANOVA with Post Hoc test, only femoral showed significant difference in SR between postures.


Conclusion: The postural effect in SR of arteries in lower limb may lead to alterations in the endothelium of arteries resulting in increased atherogenicity as compared to upper limb arteries.

Author Biographies

Vinay Kumar N

Department of Anatomy, Government Medical College, Palakkad, 678013, Kerala, India

Gugapriya T. S.

Department of Anatomy, All India Institute of Medical Sciences, Nagpur, 441108, Maharashtra, India

Guru Thangiah Arun

Hamad Medical Corporation, 60789, Qatar

Balaji P. K.

Department of General Medicine, SRM Trichy Medical College Hospital & Research Centre, Trichy, 621105 Tamil Nadu, India


Allison, M.A., Jensky, N.E., Marshall, S.J., Bertoni, A.G., Cushman, M. Sedentary behavior, and adiposity-associated inflammation: The Multi-Ethnic Study of Atherosclerosis. Am J Prev Med. 2012;42(1):8-13.

Laufs, U., Wassmann, S., Czech, T., Munzel, T., Eisenhauer, M., Bohm, M., et al., Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis. Arter Thromb Vasc Biol. 2005;25(4):809-814.

Navasiolava, N.M., Dignat-George, F., Sabatier, F., Larina, I.M., Demiot, C., Fortrat, J.O., et al., Enforced physical inactivity increases endothelial microparticle levels in healthy volunteers. Am J Physiol-Heart C. 2010;299(2):248-256.

Goyal, A., Yusuf, S. The burden of cardiovascular disease in the Indian subcontinent. Indian J Med Res.2006;124: 235-244.

Kroger, K., Kucharczik, A., Hirche, H., Rudofsky, G. Atherosclerotic lesions are more frequent in femoral arteries than in carotid arteries independent of increasing number of risk factors. Angiology.1999;50:649-654.

Amato, M., Sansaro, D., Ravani, A.L. Brachial artery diameter enlargement: a new marker of atherosclerosis? J Am Coll Cardiol. 2012; 60:1489-1499.

Soulis, J.V., Farmakis, T.M., Giannoglou, G.D., Hatzizisis, I.S., Giannakoulas, G.A., Parcharidis, G.E., et al., Molecular viscosity in the normal left coronary arterial tree. Is it related to atherosclerosis? Angiology. 2006; 57:33-40.

Papaioannou, T.G., Stefanadis, C. Vascular wall shear stress: basic principles and methods. Hellenic J Cardiol. 2005;46: 9-15.

Cunningham, K.S., Gotlieb, A.I. The role of shear stress in the pathogenesis of atherosclerosis. Lab Invest. 2005;85(1):9-23.

Stroev, P.V., Hoskins, P.R., Easson, W.J. Distribution of wall shear rate throughout the arterial tree: a case study. Atheroscler. 2007;191(2):276-280.

Caro, C.G. Discovery of the Role of Wall Shear in Atherosclerosis. Arterioscler Thromb Vasc Biol. 2009;29:158-161.

Tinken, T.M., Thijssen, D.H., Hopkins, N., Black, M.A., Dawson, E.A., Minson, C.T., et al., Impact of shear rate modulation on vascular function in humans. Hypertension. 2009;54: 278-285.

Wu, S.P., Ringgaard, S., Oyre, S., Hansen, M.S., Rasmus, S., Pedersen, E.M. Wall shear rates differ between the normal carotid, femoral, and brachial arteries: an in vivo MRI study. J Magn Reson Imaging. 2004;19(2):188-193.

Nishiyama, S.K., Walter Wray, D., Berkstresser, K,, Ramaswamy, M., Richardson, R.S. Limb-specific differences in flow-mediated dilation: the role of shear rate. J Appl Physiol. 2007;103: 843-851.

Jackson, M., Wood, N.B., Zhao, S., Augst, A., Wolfe, J.H., Gedroyc, W.M., et al., Low wall shear stress predicts subsequent development of wall hypertrophy in lower limb bypass grafts. Artery Res. 2009;3: 32-38.

Schreuder, T.H., Green, D.J., Hopman, M.T., Thijssen, D.H. Acute impact of retrograde shear rate on brachial and superficial femoral artery flow?mediated dilation in humans. Physiol Rep.2014;2(1):1-8.

Ozcan, H., Oztekin, P.S., Zergeroglu, A.M., Ersoz, G., Fiçicilar, H., Ustuner, E. Doppler ultrasound evaluation of the structural and hemodynamic changes in the brachial artery following two different exercise protocols. Diagn Interv Radiol. 2006;12: 80-84.

Johnson, B.D., Wallace, J.P. A comparison of post exercise shear rate patterns following different intensities and durations of running in healthy men. Clin Physiol Funct Imag. 2012;32(3):234-240.

Newcomer, S.C., Sauder, C.L., Kuipers, N.T., Laughlin, M.H., Ray, C.A. Effects of posture on shear rates in human brachial and superficial femoral arteries. Am J Physiol Heart Circ Physiol. 2008;294(4):1833-1839.

Thosar, S.S., Johnson, B.D., Johnston, J.D., Wallace, J.P. Sitting and endothelial dysfunction: the role of shear stress. Med Sci Monit. 2012;18(12):173-180.

Heron, M. National vital statistics reports: from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System. 2011;59(8):1-96.

Mokdad, A.H., Marks, J.S., Stroup, D.F., Gerberding, J.L. Actual causes of death in the United States,2000. J Am Med Assoc. 2004; 291(10):1238-1245.

Duivenvoorden, R., VanBavel, E., de Groot, E., Stroes, E.S., Disselhorst, J.A., Hutten, B.A., et al., Endothelial shear stress: a critical determinant of arterial remodeling and arterial stiffness in humans-a carotid 3.0-T MRI study. Circ Cardiovasc Imag. 2010; 3:578-585.

Mongrain, R., Rodes-Cabau, J. Role of shear stress in atherosclerosis and restenosis after coronary stent implantation. Rev Esp Cardiol. 2006;59(1):1-4.

Eiken, O., Kolegard, R. Comparison of vascular distensibility in the upper and lower extremity. Acta Physiol Scand. 2004;181: 281-287.




How to Cite

N VK, T. S. G, Arun GT, P. K. B. A doppler ultrasonographic observation of interventional postural alterations on shear rates in peripheral arteries. Biomedicine [Internet]. 2022 May 1 [cited 2022 Nov. 27];42(2):214-8. Available from: https://biomedicineonline.org/home/article/view/1017



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