Clinical features of acute ischemic stroke in moderately and severely ill patients with coronavirus disease 2019 (COVID-19)

Authors

  • Yethindra Vityala
  • Elmira Mamytova
  • Dzhamalbek Turgumbaev
  • Aliya Kadyrova
  • Anara Toktomametova
  • Emir Zholdoshev
  • Kunduz Karbozova
  • Tugolbai Tagaev
  • Middela Karthik
  • Kalikiri Sandhya

DOI:

https://doi.org/10.51248/.v41i2.1045

Keywords:

Acute ischemic stroke, COVID-19, clinical features, C-reactive protein, acute respiratory distress syndrome

Abstract

Introduction and Aim: Although coronavirus disease 2019 (COVID-19) causes respiratory illness, it can even develop hypercoagulation and thrombotic complications. The main objective is to study the clinical features of acute ischemic stroke (AIS) with COVID-19 in moderately and severely ill patients.

 

Materials and Methods: A retrospective analysis of thirty-four (34) patients who were infected with COVID-19 and even diagnosed with AIS in September 2020 was assessed. The main clinical and neurological characteristics of stroke, the results of clinical, laboratory, biochemical, coagulation, lipid metabolism, and clinical examination studies of COVID-19 were assessed.

 

Results: The stroke severity, severity of brain damage, and degree of disability were reported more in the severely ill patients than in the moderately ill patients (p < 0.001, p = 0.002, and p = 0.7). Data from clinical-laboratory and biochemical parameters in moderately and severely ill patients showed that a more significant parameters are C-reactive protein (0.93 ± 0.03) and (5.79 ± 0.1); D-dimer (0.39 ± 0.11) and (0.76 ± 0.14); leukocytes (4.2 ± 1.69) and (3.6 ± 1.32), respectively (p < 0.001) and slightly altered values for fasting blood glucose levels (8.61 ± 2.41) and (7.21 ± 3.15). After clinical and pathomorphological analysis, acute respiratory distress syndrome signs were observed only in severely ill patients in 14 (41.1%).

 

Conclusion: Among all the parameters characterizing clinical-laboratory and biochemical differences, inflammatory and infectious markers, and fasting glucose were higher. In moderately and severely ill patients with AIS and COVID-19 has a significantly favorable outcome with a longer hospital stay.

Author Biographies

Yethindra Vityala

Department of Pathology, International Higher School of Medicine, International University of Kyrgyzstan, Bishkek, Kyrgyzstan

Elmira Mamytova

A.N. Murzaliev Department of Neurology and Clinical Genetics, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan

Dzhamalbek Turgumbaev

Department of Neurology, Neurosurgery and Psychiatry, S.B. Daniyarov Kyrgyz State Medical Institute for Retraining and Advanced Studies, Bishkek, Kyrgyzstan

Aliya Kadyrova

Department of Radiology, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan

Anara Toktomametova

National Hospital under the Ministry of Health of the Kyrgyz Republic, Bishkek, Kyrgyzstan

Emir Zholdoshev

A.N. Murzaliev Department of Neurology and Clinical Genetics, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan

Kunduz Karbozova

A.N. Murzaliev Department of Neurology and Clinical Genetics, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan

Tugolbai Tagaev

Department of Hospital Internal Medicine, Occupational Pathology with a Course of Hematology, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan

Middela Karthik

Department of Pharmaceutics, Pathfinder Institute of Pharmacy Education and Research, Kakatiya University, Warangal, Telangana, India

Kalikiri Sandhya

Sri Venkateswara Institute of Medical Sciences-Sri Padmavathi Medical College for Women, Tirupati, Andhra Pradesh, India

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Published

2021-09-07

How to Cite

1.
Vityala Y, Mamytova E, Turgumbaev D, Kadyrova A, Toktomametova A, Zholdoshev E, Karbozova K, Tagaev T, Karthik M, Sandhya K. Clinical features of acute ischemic stroke in moderately and severely ill patients with coronavirus disease 2019 (COVID-19). Biomedicine [Internet]. 2021Sep.7 [cited 2021Sep.22];41(2):397-400. Available from: https://biomedicineonline.org/index.php/home/article/view/1045

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