Clinical usefulness of eosinopenia in differentiating COVID-19 versus other flu-like illness in outpatient set-up

Authors

  • Koushik Muthu Raja M
  • R. Anand
  • V.G. Vinod
  • B Rajagopalan
  • C. Chandrasekar
  • T Dhanasekar

DOI:

https://doi.org/10.51248/.v41i2.1066

Keywords:

COVID, Eosinopenia, Lymphopenia, flu-like illnesses

Abstract

Introduction and Aim:Corona virus disease 2019 (Covid-19) is a highly infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has affected over 200 countries and territories. The aim of the present study is to evaluate the role of eosinopenia in differentiating COVID-19 suspect from other    flu-like illnesses in an outpatient setting.

 

Materials and Methods:It was a retrospective case control study in which data of 1252 suspected COVID 19 patients who visited the fever clinic were enrolled. Among this, 701 patients were found to have COVID-19 pneumonia and 551 had other flu-like illnesses. CBC (complete blood count) and CRP(C- reactive protein) were taken in all patients along with chest x-ray as routine protocol.

 

Results:Among the 701 positive patients, eosinopenia was seen in 527 patients and had a sensitivity of 75.2 % and specificity of 68.6 %. When combined with other lab parameters such as the increased CRP and lymphopenia, the specificity rises up to 78.6 %.

 

Conclusion:Our study shows that eosinopenia as an independent variable, is a reliable marker to differentiate COVID-19 suspect patients from other flu-like illnesses on outpatient basis, however when combined with other parameters like lymphopenia and CRP the specificity increases further.

Author Biographies

Koushik Muthu Raja M

Department of Respiratory Medicine, Sri Ramachandra Medical College and Research Institute,Porur Chennai, Tamil Nadu, India

R. Anand

Department of Respiratory Medicine, Sri Ramachandra Medical College and Research Institute,Porur Chennai, Tamil Nadu, India

V.G. Vinod

Department of Respiratory Medicine, Sri Ramachandra Medical College and Research Institute,Porur Chennai, Tamil Nadu, India

B Rajagopalan

Department of Respiratory Medicine, Sri Ramachandra Medical College and Research Institute,Porur Chennai, Tamil Nadu, India

C. Chandrasekar

 

Department of Respiratory Medicine, Sri Ramachandra Medical College and Research Institute,Porur Chennai, Tamil Nadu, India

T Dhanasekar

Department of Respiratory Medicine, Sri Ramachandra Medical College and Research Institute,Porur Chennai, Tamil Nadu, India

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Published

2021-09-07

How to Cite

1.
Muthu Raja M K, Anand R, Vinod V, Rajagopalan B, Chandrasekar C, Dhanasekar T. Clinical usefulness of eosinopenia in differentiating COVID-19 versus other flu-like illness in outpatient set-up. Biomedicine [Internet]. 2021Sep.7 [cited 2021Sep.22];41(2):498-501. Available from: https://biomedicineonline.org/index.php/home/article/view/1066