Does the intrauterine condition dictate chronic metabolic disorders in the adult life?

Authors

  • Megha Bhat Agni
  • Pramukh Subrahmanya Hegde
  • Praveen Rai
  • Damodara Gowda K. M.

DOI:

https://doi.org/10.51248/.v42i2.1260

Abstract

Foetal development has dictated by maternal gestational diet and intrinsic factors, physical activity, and environmental stimulations. Many studies provided evidence for metabolic disorders in adult life who underwent under nutrition during their foetal life.  This review is an effort to use the published data to know the effect of the intrauterine environment on chronic metabolic disorders. Here, we discuss the impact of foetal under nutrition on the development of chronic metabolic diseases. Intrauterine under nutrition negatively influences health after birth. In adults, under-nutrition in utero results in metabolic impairments and cognitive impairments. Under nutrition during foetal/embryonic development influences human physiology and has a lifelong effect, often called foetal programming. This review concludes that the intrauterine environment and foetal nutrition play a significant role in developing chronic metabolic disorders. Therefore, this study provides the necessary insight into target timely interventions in the earliest possible time to prevent offspring from developing chronic diseases in adult life.

Author Biographies

Megha Bhat Agni

Department of Physiology, K.S. Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, Karnataka- 575018

Pramukh Subrahmanya Hegde

Department of Physiology, K.S. Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, Karnataka- 575018

Praveen Rai

Nitte University Centre for Science Education and Research, Nitte (Deemed to be University), Paneer Campus, Deralakatte, Mangalore-575018

Damodara Gowda K. M.

Department of Physiology, K.S.Hegde Medical Academy, Nitte (Deemed to be University)

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Published

2022-05-01

How to Cite

1.
Agni MBA, Hegde PS, Rai P, Gowda K. M. D. Does the intrauterine condition dictate chronic metabolic disorders in the adult life?. Biomedicine [Internet]. 2022 May 1 [cited 2022 Nov. 27];42(2):199-202. Available from: https://biomedicineonline.org/home/article/view/1260

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