Synthesis, anticancer and antimitotic activity of analogues of podophyllotoxin on B16F10 melanoma cell lines and Allium cepa L.
Introduction and Aim: As a timely need for potent anticancer drugs, we attempted to synthesize analogues of podophyllotoxin which are related to etoposide and tenoposide presently in the market.
Materials and Methods: Compounds 8-13 were synthesized at standard condition by modifying the ring C structure of the parent podophyllotoxin and characterized by IR, NMR, Mass spectra and elemental analysis. Anticancer (MTT assay) activity for synthetic compounds was carried out on B16F10 mouse melanoma cell lines and antimitotic activity (cytotoxic) assay was on mitotic cells of root tips of Allium cepa L.
Results: Analogues 8 and 9 exhibited greater anticancer activity with the IC50 values of 1.6 and 1.75mM respectively, and strong inhibition of mitosis with the ID50 values of 1.85mM and 2.10mM respectively, whereas the analogues 10, 11, 12 and 13 showed moderate anticancer activity.
Conclusion: Analogues 8 and 9 would become the novel anticancer drugs in future for cancer chemotherapy after further investigations.
Keywords: Synthesis; podophyllotoxin; anticancer; antimitotic.
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