To unravel the role of TCF7L2 (Transcription Factor 7 like 2) variants in type 2 diabetes mellitus


  • Shubhra Chowdhry
  • Gyanendra Kumar Sonkar
  • Priyanka Thapa Manger
  • Mohammad Mustufa Khan
  • Roshan Alam
  • Saba Khan



TCF7L2, T2DM, Wnt, SNP, GLP-1


Predisposition to diabetes is attributed to a large number of genes. TCF7L2 is one of the most significant candidate genes among them, and it is crucial for beta-cell activity and blood glucose regulation. According to previous research, TCF7L2 has been implicated in T2DM in various Indian tribes. Many studies have discovered a link between TCF7L2 gene variations and vulnerability to T2DM. These results suggest that changes in TCF7L2 expression are not only associated with insulin resistance but also with risk for genotypes connected to poor beta cell activity. TCF7L2 drives the conventional Wnt signalling pathway and functions as a nuclear ligand for beta catenin. Wnt signalling is necessary for intestinal endocrine L-cells to emit GLP-1 (glucagon-like peptide-1). As a result, a blockage in this route would cause less GLP-1 to be released, which might have an impact on the release of insulin after meals contributing to T2DM as a result. The molecular processes through which the TCF7L2 gene increases the susceptibility of T2DM will therefore be of significant interest, as will the identification of possible therapeutic targets that may be employed to treat and prevent the illness as a result of the gene variations.

Author Biographies

Shubhra Chowdhry

Department of Biochemistry, Integral Institute of Medical Sciences & Research, Integral University, Lucknow, 226026, Uttar Pradesh, India

Gyanendra Kumar Sonkar

Department of Biochemistry, King George’s Medical University, Lucknow, 226003, Uttar Pradesh, India

Priyanka Thapa Manger

Department of Biochemistry, Integral Institute of Medical Sciences & Research, Integral University, Lucknow, 226026, Uttar Pradesh, India

Mohammad Mustufa Khan

Department of Basic Medical Sciences, Integral Institute of Medical Sciences & Research, Integral University, Lucknow, 226026, Uttar Pradesh, India

Roshan Alam

Department of Biochemistry, Integral Institute of Medical Sciences & Research, Integral University, Lucknow, 226026, Uttar Pradesh, India

Saba Khan

Department of Biochemistry, Integral Institute of Medical Sciences & Research, Integral University, Lucknow, 226026, Uttar Pradesh, India


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How to Cite

Chowdhry S, Kumar Sonkar G, Thapa Manger P, Mustufa Khan M, Alam R, Khan S. To unravel the role of TCF7L2 (Transcription Factor 7 like 2) variants in type 2 diabetes mellitus. Biomedicine [Internet]. 2023 May 4 [cited 2023 Dec. 2];43(02):535-40. Available from:

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