Are lipid ratios better indices for evaluating hyperlipidemia? A prospective observational study from a rural region of North Kerala

Authors

  • Simi T. K.
  • Rebecca Abraham
  • Sangeetha V. Joice

DOI:

https://doi.org/10.51248/.v43i02.2320

Keywords:

Atherogenic coefficient, Castelli risk index, dyslipidemia, fatty liver

Abstract

Introduction and Aim: Historically lipid profile has been used to evaluate hyperlipidemia. More recently lipid ratios have been used particularly in studies from the west. The aim of this study is to evaluate dyslipidemia using both the conventional lipid profile and lipid ratios and to assess its relationship with fatty liver disease.

 

Materials and Methods: Fasting lipid profile, lipid ratios such as the Castelli Risk Index-I (CR-I TC/HDL), Castelli Risk Index II (CR-II LDL/HDL), atherogenic coefficient (non-HDL/HDL) were assessed in our study population of 150 subjects. Any changes noted in serum lipids were correlated with ultrasonography of the liver.

 

Results: Significant changes in lipid ratios such as CR-II was noted in the age group 50-59 years and was statistically significant (p=0.053).CR-I, CR-II and AC indicated a cardiovascular risk prevalence of 22.6%,36.7% and 50.7% respectively. The two ratios which were significantly altered across the various subtypes of fatty liver were LDL/HDL(p=0.018) and non-HDL/HDL (p=0.00).

 

Conclusion: This study emphasizes the importance of lipid ratios in early screening.

Author Biographies

Simi T. K.

Department of Biochemistry, Malabar Medical College Hospital and Research Centre, Ulliyeri, Kozhikode, Kerala, India

Rebecca Abraham

Department of Biochemistry, Malabar Medical College Hospital and Research Centre, Ulliyeri, Kozhikode, Kerala, India

Sangeetha V. Joice

Department of Biochemistry, Malabar Medical College Hospital and Research Centre, Ulliyeri, Kozhikode, Kerala, India

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Published

2023-05-04

How to Cite

1.
T. K. S, Abraham R, V. Joice S. Are lipid ratios better indices for evaluating hyperlipidemia? A prospective observational study from a rural region of North Kerala. Biomedicine [Internet]. 2023 May 4 [cited 2024 Mar. 29];43(02):590-4. Available from: https://biomedicineonline.org/index.php/home/article/view/2320

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