Salivary glucose as an alternative reliable marker in diabetes mellitus: A systematic review


  • Anuradha G.
  • Swathi K. V.
  • Arvind M.



Diabetes Mellitus Type II, saliva, Glucose, diagnosis, Blood glucose


Introduction and Aim: Diabetes mellitus (DM) is a chronic metabolic endocrine condition characterised by elevated blood glucose levels that can be brought on by insulin resistance, insulin deficiency, or both. As a non-invasive diagnostic tool, saliva is a complex biological fluid that contains numerous enzymes, growth factors and microbial antibodies. The objective of this systematic review is to examine and analyse published studies that have estimated the levels of salivary glucose in people with type 1 diabetes.


Materials and Methods: MeSH terms from the electronic search database engines such as PubMed, PubMed Central, Science Direct, Cochrane Library and Google Scholar were extensively used in this search methodology in this systematic review. The precise audit has been enlisted in the PROSPERO data set (Enrolment Number: CRD42021287015). 18 articles were retrieved all together. This systematic review included two articles after the application of the inclusion and exclusion criteria.


Results: A total of 347 type 1 DM cases (174 controlled diabetics, 173 uncontrolled diabetics) and 84 controls were dissected for the appraisal of the salivary glucose levels. Using Review Manager 5.4.1, a quality assessment of the included studies produced risk of bias and applicability concern graphs.


Conclusion: The emerging field of salivary diagnostics provides real-time diagnostic values for numerous diseases. The salivary and serum glucose concentrations in Type 1 diabetes were found to be statistically correlated in the studies analysed in this systematic review, thus making them a useful monitoring tool for determination of the disease’s status.

Author Biographies

Anuradha G.

Department of Oral Medicine and Radiology, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India

Swathi K. V.

Department of Oral Medicine and Radiology, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India

Arvind M.

Department of Oral Medicine and Radiology, Saveetha Dental College, Chennai, Tamil Nadu, India


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How to Cite

G. A, K. V. S, M. A. Salivary glucose as an alternative reliable marker in diabetes mellitus: A systematic review. Biomedicine [Internet]. 2023 May 4 [cited 2024 Mar. 3];43(02):559-66. Available from:

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