Evaluation of the anti-inflammatory potential of Solanum pubescens fruit extract


  • Salah Aldeen Ahmed Naji Ismail
  • Riaz Mahmood
  • Haseebur Rahman




Solanum pubescens, Anti-inflammation, carrageenan, cotton pellet, IL-6


Introduction and Aim: Solanum pubescens is one of the very well-known traditional medicinal plants it has been widely used in the treatment of many inflammatory conditions. This study aimed to evaluate the anti-inflammatory property of S. pubescens fruit.


Materials and Methods: Anti-inflammatory activities of S. pubescens fruit extracts at different concentrations (100-200 mg/kg) were carried out using carrageenan-induced and cotton implant-induced granuloma methods.


Results: The results of the carrageenan-induced paw edema study reveals the highest activity of fruit upper ethanolic (FUEE) extract at 200 mg/kg, with 64.84% followed by water (FEW), and fruit lower ethanolic extracts (FLEE). The protein and IL-6 evaluation in this experiment showed very promising results. Whereas the cellular toxicity was evaluated in terms of LPO, MPO and nitric oxide analysis which in turn showed harmless nature of extracts. Furthermore, assessment of proliferative phase of inflammation was done in rats using a cotton pellet-induced granuloma model, where FUEE at 100 mg/kg showed 32.5±2.73 mg, 200 mg/kg 25.3±2.36 mg of dry weight of granuloma, compared to the standard indomethacin activity 1.4±3.45 mg. Moreover, the hematological parameters of treated animals reveals that the erythrocyte sedimentation rate (ESR) of FUEE 4.88± 0.18 mm/hr at 200 mg/kg was the least and almost equal to the standard.


Conclusion: It can be said that S. pubescens is no doubt a very good source of phytomedicine for the treatment of inflammatory diseases, with most of the valuable phytoconstituents concerned with the anti-inflammation assembled in the fruit upper ethanolic extracts as this extract showed excellent activity in both the carrageenan and cotton pellet models.

Author Biographies

Salah Aldeen Ahmed Naji Ismail

Department of Biotechnology and Bioinformatics, Jnanasahyadri, Kuvempu University, Shankaraghatta, 577451, Shimoga District., Karnataka, India

Riaz Mahmood

Department of Biotechnology and Bioinformatics, Jnanasahyadri, Kuvempu University, Shankaraghatta, 577451, Shimoga District., Karnataka, India

Haseebur Rahman

Department of Biotechnology and Bioinformatics, Jnanasahyadri, Kuvempu University, Shankaraghatta, 577451, Shimoga District., Karnataka, India


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How to Cite

Aldeen Ahmed Naji Ismail S, Mahmood R, Rahman H. Evaluation of the anti-inflammatory potential of Solanum pubescens fruit extract. Biomedicine [Internet]. 2023 May 25 [cited 2024 Mar. 3];43(02):674-83. Available from: https://biomedicineonline.org/index.php/home/article/view/2687



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