A review on anticancer potential of Quercus infectoria and its bioactive compounds


  • Illyana Ismail School of Biomedicine, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Gong Badak Campus, 21300 Kuala Terengganu, Terengganu, MALAYSIA
  • Veshalini Kasiraja School of Biomedicine, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Gong Badak Campus, 21300 Kuala Terengganu, Terengganu, MALAYSIA
  • Hasmah Abdullah Biomedicine Programme, School of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kota Bharu Kelantan, MALAYSIA




Quercus infectoria, anticancer, tannic acid, gallic acid, ellagic acid


Cancer is a life-threatening disease if not diagnosed and treated early. Available cancer treatments with undesirable side effects have led to the search for safer and more effective treatments. Therapeutic intervention using plant-derived natural products have been of great interest these days. Many plant-derived phytochemicals have been implicated with anticancer activities. Quercus infectoria is one of the prominent candidates for its chemopreventive mechanisms of action in cancer. Worldwide, this plant has been used in various medicinal purposes. Based on the available data from previous scientific researches, this review focuses on the anticancer potentials of Q. infectoria, as well as its bioactive compounds such as tannic acid, gallic acid and ellagic acid. This review will trigger of generating new insights into possible application of this plant in cancer therapy. 


Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., et al., Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015; 136(5): E359-E386.

Tajudin, T.J.S.A., Mat, N., Siti-Aishah A. B., Yusran A.A.M., Alwi A., Ali A. M. Cytotoxicity, antiproliferative effects, and apoptosis induction of methanolic extract of cynometra cauliflora linn. Whole fruit on human promyelocytic leukemia HL-60 cells. Evidence-based Complement Altern Med. 2012; 1-6.

Khalili, R.M.A., Noratiqah, J. M., Norhaslinda, R., Norhayati, A. H., Amin, B. A., Roslan, A., et al., Cytotoxicity effect and morphological study of different duku (Lansium domesticum corr.) Extract towards human colorectal adenocarcinoma cells line (HT-29). Pharmacogn J. 2014; 9(6): 757-761.

Ismail, I., Sulong, S., Al Jamal, H., Johan, M. F., Hassan, R. Differential expression profiles of miRNAs and correlation with clinical outcomes in acute myeloid leukemia. Meta Gene. 2018; 16: 182-188.

Desai, A., Qazi, G., Ganju, R., El-Tamer, M., Singh, J., Saxena, A., et al., Medicinal Plants and Cancer Chemoprevention. Curr Drug Metab. 2008; 9(7): 581-591.

Ulrich-Merzenich, G. S. Combination screening of synthetic drugs and plant derived natural products-Potential and challenges for drug development. Synergy. 2014; 1(1): 59-69.

Greenwell, M., Rahman, P.K.S.M. Medicinal Plants: Their Use in Anticancer Treatment. Int J Pharm Sci Res. 2015; 6(10): 4103-4112.

Wang, S. J., Zheng, C. J., Peng, C., Zhang, H., Jiang, Y. P., Han, T., et al., Plants and cervical cancer: An overview. Expert Opin Investig Drugs. 2013; 22(9): 1133-1156.

Shu, L., Cheung, K. L., Khor, T. O., Chen, C., Kong, A. N. Phytochemicals: Cancer chemoprevention and suppression of tumor onset and metastasis. Cancer Metastasis Rev. 2010; 29(3): 483-502.

Shrestha, S., Kaushik, V. S., Eshwarappa, R.S.B., Subaramaihha, S. R., Ramanna, L. M., Lakkappa, D. B. Pharmacognostic studies of insect gall of Quercus infectoria Olivier (Fagaceae). Asian Pac J Trop Biomed. 2014; 4(1): 35-39.

Abdul Haque, A. S., Ahmad, W., Khan, R. M., Hasan, A. Ethnopharmacology of Quercus Infectoria Olivier – Galls: A Review. Hippocratic. Hippocrat J Unani Med. 2016; 11(3): 105-118.

Aroonrerk, N., Kamkaen, N. Anti-Inflammatory Activity of Quercus infectoria, Glycyrrhiza uralensis, Kaempferia galanga and Coptis chinensis, the Main Components of Thai Herbal Remedies for Aphthous Ulcer. J Heal Res. 2009; 23(1): 17-22.

Nur Syukriah, A. R., Liza, M. S., Harisun, Y., Fadzillah, A. A. M. Effect of solvent extraction on antioxidant and antibacterial activities from Quercus infectoria (Manjakani). Int Food Res J. 2014; 21(3): 1031-1037.

Hasmah, A., Nurazila, Z., Chow, C., Rina, R., Rafiquzzaman, M. Cytotoxic Effects of Quercus infectoria Extracts towards Cervical (Hela) and Ovarian (Caov-3) Cancer Cell Lines. Heal Environ J. 2010; 1(2): 17-23.

Rocha-Guzmán, N. E., Gallegos-Infante, J. A., González-Laredo, R. F., Reynoso-Camacho, R., Ramos-Gómez, M., Garcia-Gasca, T., et al., Antioxidant activity and genotoxic effect on HeLa cells of phenolic compounds from infusions of Quercus resinosa leaves. Food Chem. 2009; 115(4): 1320-1325.

Moradi-Taghi, M., Karimi, A., Alidadi, S. In vitro antiproliferative and apoptosis-inducing activities of crude ethyle alcohole extract of Quercus brantii L. acorn and subsequent fractions. Chin J Nat Med. 2016; 14(3): 196-202.

Rehman, M. U., Tahir, M., Ali, F., Qamar, W., Khan, R., Quaiyoom, A., et al., Chemopreventive effect of Quercus infectoria against chemically induced renal toxicity and carcinogenesis. Int J Drug Dev Res. 2012; 4(2): 336-351.

Chung, K. T., Wong, T. Y., Wei, C. I., Huang, Y. W., Lin, Y., Chung, T., et al., Critical Reviews in Food Science and Nutrition Tannins and Human Health: A Review Tannins and Human Health: A Review. Crit Rev Food Sci Nutr. 1998; 386(386): 37-41.

Nam, S., Smith, D. M., Dou, Q.P.P. Tannic acid potently inhibits tumor cell proteasome activity, increases p27 and bax expression, and induces G1 arrest and apoptosis. Cancer Epidemiol Biomarkers Prev. 2001; 10(10): 1083-1088.

Baer-Dubowska, W., Szaefer, H., Majchrzak-Celi?ska, A., Krajka-Ku?niak, V. Tannic Acid: Specific Form of Tannins in Cancer Chemoprevention and Therapy-Old and New Applications. Curr Pharmacol Reports. 2020; 6(2): 28-37.

Rodríguez, H., Rivas, B., Gómez-Cordovés, C., Muñoz, R. Degradation of tannic acid by cell-free extracts of Lactobacillus plantarum. Food Chem. 2008; 107(2): 664-670.

Zhang, J., Chen, D., Han, D. M., Cheng, Y. H., Dai, C., Wu, X. J., et al., Tannic acid mediated induction of apoptosis in human glioma hs 683 cells. Oncol Lett. 2018; 15(5): 6845-6850.

Darvin, P., Baeg, S. J., Joung, Y. H., Nipin, S. P., Kang, D. Y., Byun, H. J., et al., Tannic acid inhibits the Jak2/STAT3 pathway and induces G1/S arrest and mitochondrial apoptosis in YD-38 gingival cancer cells. Int J Oncol. 2015; 47(3): 1111-1120.

Gülçin, I., Huyut, Z., Elmasta?, M., Aboul-Enein, H.Y. Radical scavenging and antioxidant activity of tannic acid. Arab J Chem. 2010;3(1):43-53.

Naus, P.J., Henson, R., Bleeker, G., Wehbe, H., Meng, F., Patel, T. Tannic acid synergizes the cytotoxicity of chemotherapeutic drugs in human cholangiocarcinoma by modulating drug efflux pathways. J Hepatol. 2007; 46(2): 222-229.

Zieli?ska-Przyjemska, M., Kaczmarek, M., Krajka-Ku?niak, V., ?uczak, M., Baer-Dubowska, W. The effect of resveratrol, its naturally occurring derivatives and tannic acid on the induction of cell cycle arrest and apoptosis in rat C6 and human T98G glioma cell lines. Toxicol Vitr. 2017; 43: 69-75.

Bona, N. P., Pedra, N. S., Azambuja, J. H., Soares, M.S.P., Spohr, L., Gelsleichter, N. E., et al., Tannic acid elicits selective antitumoral activity in vitro and inhibits cancer cell growth in a preclinical model of glioblastoma multiforme. Metab Brain Dis. 2020; 35(2): 283-293.

Verma, S., Singh, A., Mishra, A. Gallic acid: Molecular rival of cancer. Environ Toxicol Pharmacol. 2013; 35(3): 473-485.

You, B. R., Moon, H. J., Han, Y. H., Park, W. H. Gallic acid inhibits the growth of HeLa cervical cancer cells via apoptosis and/or necrosis. Food Chem Toxicol. 2010; 48(5): 1334-1340.

Zhao, B., Hu, M. Gallic acid reduces cell viability, proliferation, invasion and angiogenesis in human cervical cancer cells. Oncol Lett. 2013; 6(6): 1749-1755.

Sun, G., Zhang, S., Xie, Y., Zhang, Z., Zhao, W. Gallic acid as a selective anticancer agent that induces apoptosis in SMMC-7721 human hepatocellular carcinoma cells. Oncol Lett. 2016; 11(1): 150-158.

Zhang, H. M., Zhao, L., Li, H., Xu, H., Chen, W. W., Tao, L. Research progress on the anticarcinogenic actions and mechanisms of ellagic acid. Cancer Biol Med. 2014; 11(2): 92-100.

Losso, J. N., Bansode, R. R., Trappey, A., Bawadi, H.A., Truax, R. In vitro anti-proliferative activities of ellagic acid. J Nutr Biochem. 2004; 15(11): 672-678.

Han, D. H., Lee, M. J., Kim, J. H. Antioxidant and apoptosis-inducing activities of ellagic acid. Anticancer Res. 2006; 26(5 A): 3601-3606.

Guo, H., Zhang, D., Fu, Q. Inhibition of cervical cancer by promoting IGFBP7 expression using ellagic acid from pomegranate peel. Med Sci Monit. 2016; 22: 4881-4886.




How to Cite

Ismail I, Kasiraja V, Abdullah H. A review on anticancer potential of Quercus infectoria and its bioactive compounds. Biomedicine [Internet]. 2021Dec.31 [cited 2022Jan.20];41(4):701-5. Available from: https://biomedicineonline.org/index.php/home/article/view/298