Utility of Geboes score for assessing histological activity in ulcerative colitis

Authors

  • Cheryl Sarah Philipose
  • Sunita Hegde
  • Amit Kumar
  • Sharada Rai
  • Sneha J.
  • Sandeep Gopal
  • Hema Kini
  • Chaithra G.V.

DOI:

https://doi.org/10.51248/.v43i4.3044

Keywords:

Ulcerative colitis, Activity, Geboes score, Mayo score

Abstract

Introduction and Aim: Diagnosis of UC is challenging and calls for an integrated clinical, endoscopic, serological, and histological examination. Although inexpensive and non-invasive, endoscopic findings do not always correlate with disease activity, as demonstrated by traditional histopathological examination.

 

Materials and Methods: This retrospective study was conducted between January 2014 and December 2019. Specimens of patients diagnosed with UC that were received in the Department of Pathology were included. An experienced pathologist assessed the histological disease activity using the Geboes score. The Mayo endoscopic subscore was recorded for endoscopic activity. Results thus obtained were entered into MS Excel and analysis was done using SPSS version 25.0.

 

Results: Of the 123 cases of UC, (age, 14 to 74 years; males: 60.2%, females: 39.8%) majority had endoscopic findings of erythema and edema (n=20) with the least common finding being ileocolitis (n=1). Mayo subscore was available in 24 cases (ranging from 1 to 3; Mayo subscores of 1, 2, and 3 in 1, 14 and 9 cases respectively). Active colitis was noted in 78% (96/123) of the patients while the remaining 22% (27/123) of patients had inactive colitis. Only 24 cases had both Mayo subscore and Geboes score correlation. Fourteen cases had a Mayo subscore of 2 and a Geboes score ranging from 2A to 5.2; 9 cases had a Mayo subscore of 3 and a Geboes score ranging from 4.1 to 5.2.

 

Conclusion: Assessment of histological disease activity by Geboes score provides useful information in routine reporting of biopsy specimens of cases of Ulcerative colitis

Author Biographies

Cheryl Sarah Philipose

Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India

Sunita Hegde

Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India

Amit Kumar

Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India

Sharada Rai

Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India

Sneha J.

Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India

Sandeep Gopal

Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India

Hema Kini

Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India

Chaithra G.V.

Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India

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Published

2023-08-30

How to Cite

1.
Sarah Philipose C, Hegde S, Kumar A, Rai S, J. S, Gopal S, Kini H, G.V. C. Utility of Geboes score for assessing histological activity in ulcerative colitis. Biomedicine [Internet]. 2023 Aug. 30 [cited 2023 Oct. 4];43(4):1296-301. Available from: https://biomedicineonline.org/index.php/home/article/view/3044

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