Physical and psychological symptom burden from long Covid and correlation with clinico-radiological and biochemical profile of hospitalized patients with acute COVID-19 due to Delta variant of SARS-CoV-2


  • Jayamol Revendran
  • Meenakshi Narasimhan



COVID- 19 infection, Long COVID, Symptoms


Introduction and Aim: It is crucial to identify the burden of post COVID long-term morbidity denoted as long-COVID. Our study aims to determine prevalence of Long-COVID and to identify indicators which can predict chances of developing this condition. The aim was to study the persisting symptoms and predictors for long-COVID in COVID-19 patients.


Materials and Methods: All patients hospitalized with acute COVID-19 infection from 1st April 2021 to 30th June 2021 with a positive RT-PCR were followed up through telephonic interview after 6 months of discharge. All clinical, laboratory, radiological data of patients during their hospital admission was retrieved from medical records. Current physical and psychological symptom burden (PHQ2 score) was recorded using a structured questionnaire and analysed.


Results: Total of 101 patients were included. Mean age was 47yrs. M: F=2:1. Mean number of hospital stays was 7 days (1-34). Most patients needed admission on 5th day of illness (1-14). Mean CRP, D Dimer and Ferritin values were 77 mg/dl, 335 ng/ml, 414 microgram/ml respectively. Mean CT severity score was 12. The most common comorbidity was Type 2 Diabetes mellitus followed by hypertension. Of all patients, 16 % had symptoms of long COVID during 6 months post COVID infection. Most common symptoms were fatigue (60%), exercise intolerance (55%), cough (18%), breathlessness (18%), disturbed sleep quality (10%) and depression in 9.7% of patients as assessed by PHQ2 Score (1-6). None of the predictive factors were found to have statistically significant correlation with development of Long- COVID.


Conclusion: Of all patients hospitalised with COVID-19, 16 % had long COVID symptoms at 6 months assessment. Majority had fatigue and exercise intolerance but one tenth also had depression. Multispecialty COVID follow up clinics are necessary for further assessment and rehabilitation of these patients.

Author Biographies

Jayamol Revendran

Department of Pulmonary Medicine, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India

Meenakshi Narasimhan

Department of Pulmonary Medicine, Chettinad Academy of Research and Education, Chennai, Tamil Nadu, India


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How to Cite

Revendran J, Narasimhan M. Physical and psychological symptom burden from long Covid and correlation with clinico-radiological and biochemical profile of hospitalized patients with acute COVID-19 due to Delta variant of SARS-CoV-2. Biomedicine [Internet]. 2023 Nov. 9 [cited 2023 Dec. 2];43(5):1582-6. Available from:



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