Serum microRNAs dysregulation in cervical cancer and their diagnostic role: A systematic review




Cervical cancer, miRNA, dysregulation, diagnosis


Cervical cancer is the fourth-highest prevalent tumor among women in the world. Though the development in the early diagnosis of cervical cancer in developed countries, developing countries are still suffering from it. Among the different biomarkers, serum microRNAs (miRNAs) were reported as valuable tools in the diagnosis of cervical cancer. To highlight the most recent studies of the serum miRNAs in cervical cancer diagnosis, we systematically searched science direct and Web of Science databases using keywords, and the articles that meet inclusion criteria and do not meet exclusion criteria are included in the current review for further analysis. After applying the current study inclusion and exclusion criteria we found 42 dysregulated miRNAs, among them miR-21 was the most investigated, and most of them were capable of distinguishing between healthy and cervical cancer subjects. The current study shows the importance of serum miRNAs as biomarkers in cervical cancer diagnosis.

Author Biographies

Hussein Hameed Abbas

Department of Human Genetics and Molecular Biology, Bharathiar University, Maruthamalai Main Road, Coimbatore, 641046, Tamil Nadu, India

Fenwick Antony Edwin Rodrigues

Department of Human Genetics and Molecular Biology, Bharathiar University, Maruthamalai Main Road, Coimbatore, 641046, Tamil Nadu, India

Sivasamy Ramasamy

Department of Human Genetics and Molecular Biology, Bharathiar University, Maruthamalai Main Road, Coimbatore, 641046, Tamil Nadu, India


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How to Cite

Abbas HH, Edwin Rodrigues FA, Ramasamy S. Serum microRNAs dysregulation in cervical cancer and their diagnostic role: A systematic review. Biomedicine [Internet]. 2023 Nov. 8 [cited 2023 Dec. 2];43(5):1385-90. Available from:

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