Role of immunological and biochemical markers in bone turnover in type I diabetic patients in Karbala province, Iraq

Ahmed Abbas Hasan; Hams Ahmed Al Jndeel; Humam Kasem Hussein

doi:10.51248/.v43i5.3265

Authors

Ahmed Abbas Hasan
Hams Ahmed Al Jndeel
Humam Kasem Hussein

DOI:

https://doi.org/10.51248/.v43i5.3265

Keywords:

Diabetes mellitus, pro-inflammatory cytokines, HbA1c, vitamin D, sPINP, sCTX

Abstract

Introduction & Aim: Long-term diabetes mellitus (DM) is known to have a deleterious impact on bone health, resulting in change in bone mineral density, bone turnover, and bone quality, all of which increase the risk of fractures. The aim of. this study was to link immunological and pro-inflammatory cytokine (I.L-6, I.L-1, and TNF-alpha) markers in patients.with type 1 diabetes to Their connection to bones formation (sPINP) and bone resorption parameters (sCTX).

Materials & Methods: This study included 80 patients suffering from T1DM in the age range of 20-45 years. The patients were assayed for their biochemical (Vitamin D and HbA1c), Immunological (IL-6, IL-1 and TNF-alpha) parameters, as well as bone formation and resorption markers.

Results: HbA1c values were observed to be 7.5 in 85% of individuals, while vitamin D levels were 16 ng/mL. Correlation in patients with HbA1c 7.5. The results of a linear regression between I.L-6 and sCTX showed that there was an increase in sCTX for each unit of IL-6.

Conclusion: In patients with HbA1c levels 7.5, there is an association between IL-6, TNFalpha, and the bone resorption. TNF-alpha and IL-6 have been linked to metabolic control loss.

Author Biographies

Ahmed Abbas Hasan

Department of Clinical Laboratory Sciences, College of Pharmacy, University of Karbala, Karbala, Iraq

Hams Ahmed Al Jndeel

College of Pharmacy, University of Karbala, Karbala, Iraq & Department of Laboratory Technologies, College of Al-Zahrawi University ID: 122473929, Iraq

Humam Kasem Hussein

Al-Furat Al-Awsat Technical University/Technical institute of Najaf, Iraq

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