Correlation of sdLDL-C with cardiometabolic risk indices in women with subclinical hypothyroidism– A cross-sectional study


  • Samyuktha Rani V.
  • Rukmini M. S.
  • Nandini M.
  • Ashok Prabhu K.



Subclinical hypothyroidism, sdLDL-C, cardiometabolic risk indices, atherogenic index


Introduction and Aim: Subclinical hypothyroidism (SCH) characterised by normal free thyroxine (FT4)­­, “free triiodothyronine (FT3)”, and raised serum TSH, is an early stage of mild thyroid hormone deficiency. A change in the lipid profile most often observed in SCH is mainly caused by increased serum levels of Triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C), whereas high-density lipoprotein cholesterol (HDL-C) levels can be normal or elevated. Studies on small dense Low Density Lipoprotein – Cholesterol (sdLDL-C), associated with CVD risk are few. The aim of this study was to estimate serum sdLDL-C and find its correlation with thyroid profile (FT4 and TSH) and cardiometabolic risk indicators in female subjects with subclinical hypothyroidism.


Materials and Methods: The study had 112 female participants in total. After screening, subjects were divided into two groups. Control group (euthyroid) and study group (SCH). Age, TSH, FT4, TC, TG, HDL-C, LDL-C, sdLDL-C & Lipid ratios “(TC/HDL-C, LDL-C/HDL-C”, “Log TG/ HDL-C)” were examined and compared between the two groups.


Results: The correlation of sdLDL-C with TSH, FT4, lipid parameters & lipid ratios were studied. TG, TC, HDL-C, and LDL-C were not clinically significant. While sdLDL-C and lipid ratios had a statistical decrease, it was not clinically significant. A highly significant negative association between sdLDL-C, other lipid parameters, except HDL-C, lipid ratios are observed in the study group.


Conclusion: As anticipated, the current investigation did not demonstrate any statistically significant improvement in the sdLDL-C as a better predictor of CVD risk. No apparent lipid abnormalities were also seen in women, in the age group of 20-40 years as observed in the correlation studies. However, measurement of AIP along with FT4 would make a better assessment of CVD risk.

Author Biographies

Samyuktha Rani V.

Department of Biochemistry, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal

Rukmini M. S.

Department of Biochemistry, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal

Nandini M.

Department of Biochemistry, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal

Ashok Prabhu K.

Clinical Biochemistry Laboratory, Kasturba Medical College Hospital, Mangalore


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How to Cite

Rani V. S, M. S. R, M. N, Prabhu K. A. Correlation of sdLDL-C with cardiometabolic risk indices in women with subclinical hypothyroidism– A cross-sectional study. Biomedicine [Internet]. 2023 Aug. 30 [cited 2023 Oct. 4];43(4):1154-61. Available from:



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