Risk of fractures in patients with osteoporosis associated with chronic heart failure and type 2 diabetes mellitus


  • Daniial Chyngyshpaev
  • Orozaly Uzakov
  • Mairam Kerimaly kyzy
  • Sergey Shilov
  • Stalbek Akhunbaev
  • Aida Uzakova
  • Tugolbai Tagaev




Chronic heart failure, tumor necrosis factor-alpha, type 2 diabetes mellitus, postmenopausal women, loop diuretics


Introduction and Aim: Although the pathophysiological processes underlying the association between congestive heart failure (CHF) and osteoporosis (OP) are unknown, there is evidence that several changes observed in CHF may play a role in bone loss. The objective of the study is to examine the impact of soluble TNF-alpha receptor 1 (sR1-TNF-alpha) and soluble TNF-alpha receptor 2 (sR2-TNF-alpha) on the risk of fractures in patients with OP associated with CHF and type 2 diabetes mellitus (T2DM).


Methods: This study included 178 women aged 50–65 years, divided into four groups. Group 1 consisted of 48 women diagnosed with HF and T2DM. Group 2 included 93 patients with OP and HF. Group 3 consisted of 37 women with OP, HF, and T2DM.


Results: The levels of sR1-TNF-alpha and sR2-TNF-alpha in patient groups 1 through 3 were significantly higher than in the control group (p<0.01). Furthermore, it was demonstrated that patients in group 3 had much greater levels of both receptors than those in groups 1 and 2.


Conclusion: High levels of sR1-TNF-alpha and sR2-TNF-alpha in postmenopausal women with CHF are associated with an increased risk of a poor outcome during OP.

Author Biographies

Daniial Chyngyshpaev

Administration of International Higher School of Medicine, Bishkek, Kyrgyzstan

Orozaly Uzakov

Administration of International Higher School of Medicine, Bishkek, Kyrgyzstan

Mairam Kerimaly kyzy

Administration of the Clinical Maternity Hospital No. 2, Bishkek, Kyrgyzstan

Sergey Shilov

Department of Special Psychology, Novosibirsk State Medical University, Novosibirsk, Russia

Stalbek Akhunbaev

Administration of International Higher School of Medicine, Bishkek, Kyrgyzstan

Aida Uzakova

Department of Obstetrics and gynecology, International Higher School of Medicine, Bishkek, Kyrgyzstan

Tugolbai Tagaev

Department of Hospital Internal Medicine, Occupational Pathology with a course of Hematology, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan


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How to Cite

Chyngyshpaev D, Uzakov O, Kerimaly kyzy M, Shilov S, Akhunbaev S, Uzakova A, Tagaev T. Risk of fractures in patients with osteoporosis associated with chronic heart failure and type 2 diabetes mellitus. Biomedicine [Internet]. 2023 Nov. 9 [cited 2023 Dec. 2];43(5):1541-5. Available from: https://biomedicineonline.org/index.php/home/article/view/3374



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