Evaluation of serum macronutrients level and depression among adolescents and its association with pre-hypertension: A cross sectional study
DOI:
https://doi.org/10.51248/.v41i3.353Keywords:
Serum macronutrients, depression, pre-hypertensionAbstract
Introduction and Aim: Serum macronutrients measurement prove to be precedent values with regard to diagnose hypertension at an earlier age. Depression in any form could be ruinous to younger generation, also could precipitate hypertension. The aim of the study is to estimate serum calcium, magnesium levels, grade depression and to establish its association with prehypertension.
Materials and Methods: A cross sectional study was conducted on 68 students aged 17-19 years over a two months period. Blood samples were drawn and serum magnesium and calcium were estimated. Depression was assessed by administering KADS – 6 questionnaires. Blood Pressure was measured by auscultatory method using mercury sphygmomanometer. All parameters were presented as mean ± SD. Chi square test was used to compare proportions for the groups. Unpaired t test was used to compare the groups. ANOVA was used to compare the groups for continuous variables. Statistical analysis was done using Epi info (version 6.04d) software package.
Results: More than 44% of the study participants had elevated serum calcium levels, while about 10% of them had elevated serum magnesium levels. More than half (58.8%) of the participants were pre-hypertensive. One third of the study participants were depressed of which about 10% of them had severe depression. The prevalence of prehypertension was 2.1 times higher among participants having hypercalcemia when compared to participants who have normal serum calcium levels with 95% CI of 1.38 - 3.22 which is statistically significant (p-value < 0.001). The study could not establish a statistical difference between different groups with regards to serum magnesium levels and depression.
Conclusion: Our study portrays the widely prevalent depression and pre-hypertension in younger generation and exhibits firm evidence on measuring serum macronutrient levels to diagnose pre-hypertension before time that can prevent the disease load and help ineffective management.
References
Cunha, A. R., Umbelino, B., Correia, M. L., Neves, M. F. Magnesium and vascular changes in hypertension. International journal of hypertension. 2012 Feb 29; 2012.
Barbagallo, M., Dominguez, L. J., Galioto, A., Ferlisi, A., Cani, C., Malfa, L., et al., Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. Molecular Aspects of Medicine. 2003; 24(1-3): 39-52.
Sudhakar, K., Sujatha, M., Babu, S. R., Padmavathi, P., Reddy, P. P. Serum calcium levels in patients with essential hypertension and their first-degree relatives. Indian J Clin Biochem. 2004; 19: 21-23.
Body, J. J., Cryer, P. E., Offord, K. P., Heath, H. 3rd. Epinephrine is a hypophosphatemic hormone in man physiological effects of circulating epinephrine on plasma calcium, magnesium phosphorus, parathyroid hormone and calcitonin. J Clin Invest. 1983; 71: 572-578.
Sorof J, Daniels S. Obesity and hypertension in children: A problem of epidemic proportions. Hypertension. 2002; 40: 441-447.
Pignone, M. P., Gaynes, B. N., Rushton, J. L., Burchell, C. M., Orleans, C. T., Mulrow, C. D., et al., Screening for depression in adults: A summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2002; 136: 765-776.
Meng, L., Chen, D., Yang, Y., Zheng, Y., Hui, R. Depression increases the risk of hypertension incidence: A meta-analysis of prospective cohort studies. J Hypertens. 2012; 30: 842-851.
Tambe, B., Phadke, V., Kharche, S., Joshi, R. Correlation of blood pressure with body mass index and waist to hip ratio in middle aged men. Internet Journal of Medical Update. 2010; 5(2): 26-30.
The seventh report of the Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure. JAMA 2003; 289: 2560-2571.
Xing, L. Y., Diao, W. L., Liu, Y. Q., Yu, L. Y., Liu, L., Li, N., et al., Prevalence, awareness, treatment, control of hypertension in rural adult residents of Liaoning province. Zhonghua Xin Xue Guan Bing za zhi. 2010; 38(7): 652-655.
Anand, T., Ingle, G. K., Meena, G. S., Kishore, J., Kumar, R. Hypertension and its correlates among school adolescents in delhi. Int J Prev Med. 2014; 5(Suppl 1): S65–S70.
Sorof, J. M., Poffenbarger, T., Franco, K., Bernard, L., Portman, R. J. Isolated systolic hypertension, obesity, and hyperkinetic hemodynamic states in children. J Pediatr. 2002; 140: 660-666.
Han, H., Fang, X., Wei, X., Liu,Y., Jin, Z., Chen,Q., et al., Dose-response relationship between dietary magnesium intake, serum magnesium concentration and risk of hypertension: a systematic review and meta-analysis of prospective cohort studies. Nutr J. 2017; 16(1): 26.
Schroeder, H. A. Relations between hardness of water and death rates from certain chronic and degenerative diseases in the United States. J Chronic Dis 1960; 12: 586-591.
Sun, H., Shi, J., Wang, H., Fu, L., Zhou, B., Wu, X., et al., Association of serum calcium and hypertension among adolescents aged 12-17 years in the rural area of Northeast China. Biol Trace Elem Res. 2013 Dec; 155(3): 344-351.
Thapar, A., Collishaw, S., Pine, D.S., Thapar, A. K. Depression in adolescence. Lancet 2012; 379(9820): 1056?1067.
Davidson, K., Jonas, B. S., Dixon, K. E., Markovitz, J. H. Do Depression Symptoms Predict Early Hypertension Incidence in Young Adults in the CARDIA Study? Arch Intern Med. 2000; 160(10): 1495-1500.
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