Chemical properties of polyphenols: a reviewfocusedonanti-inflammatory and anti-viral medical application


  • Beatriz A. Cano-Avendaño
  • Juan C. Carmona-Hernandez
  • Ricardo E. Rodriguez
  • Gonzalo Taborda-Ocampo
  • Clara H. González-Correa



Chemicalconformation, polyphenols, biological function, therapeutical application


Polyphenols are attributed to multiple biological activities that providenutritional and therapeutical benefits. The present paper is a descriptive review focused on polyphenolic chemical structural aspects contributing to explain biological and biochemical functions offered by these phytochemicals. Element conformation differences, ring modifications, the presence of specific functional groups, and the tridimensional chemical arrangement are fundamental to explain specific effects presented by polyphenols. The anti-oxidant and anti-inflammatory actions of polyphenols suggest that basic chemical reactions and element re-organization are important in understanding their function, well-known polyphenols such as quercetin, curcumin, and catechin have been evaluated in multiple studies. Moreover, anti-bacterial and anti-viral activities have been proven to be dependent on hydroxylation, methoxylation, and alkylation of several polyphenol ring components. Polyphenols extracted from tea, like catechins, proved to inhibit efficiently hepatitis C, Zika, and Chikungunya viruses. They have also acted as promising prophylactic and therapeutic agents against SARS-CoV-2.Epicatechin extracted from the hawthorn tree showed antiviral activity on several bacteria such as Escherichia coli and Salmonella typhimurium. The inclusion of these natural components in daily diets is of primary nutritional benefit and importance in the prevention of several diseases.

Author Biographies

Beatriz A. Cano-Avendaño

Grupo de Investigación Médica, Universidad de Manizales, Manizales,Colombia

Juan C. Carmona-Hernandez

Grupo de Investigación Nutrición, Metabolismo y Seguridad Alimentaria, Universidad de Caldas, Manizales,Colombia

Ricardo E. Rodriguez

Dean of Arts and Sciences, Texas Wesleyan University, Fort Worth - USA

Gonzalo Taborda-Ocampo

Grupo de Investigación en Cromatografía y Técnicas Afines, Universidad de Caldas, Manizales, Colombia

Clara H. González-Correa

Grupo de Investigación Nutrición, Metabolismo y Seguridad Alimentaria, Universidad de Caldas, Manizales,Colombia


Luca, S. V., Macovei, I., Bujor, A., Miron, A., Skalicka-Wo?niak, K., Aprotosoaie, A. C., et al. Bioactivity of dietary polyphenols: The role of metabolites. Critical Reviews in Food Science and Nutrition. 2020 Feb 21; 60(4):626-659.

Magrone, T., Magrone, M., Russo, M. A., Jirillo, E. Recent advances on the anti-inflammatory and antioxidant properties of red grape polyphenols: in vitro and in vivo studies. Antioxidants. 2020 Jan; 9(1):35.

Gori, A., Nascimento, L. B., Ferrini, F., Centritto, M., Brunetti, C. Seasonal and diurnal variation in leaf phenolics of three medicinal Mediterranean wild species: What is the best harvesting moment to obtain the richest and the most antioxidant extracts? Molecules. 2020 Jan; 25(4):956.

Araújo, M., Pimentel, F. B., Alves, R. C., Oliveira, MBPP. Phenolic compounds from olive mill wastes: Health effects, analytical approach and application as food antioxidants. Trends in Food Science & Technology. 2015 Oct; 45(2):200-211.

Chaudhary, A., Jaswal, V. S., Choudhary, S., Sonika., Sharma A., Beniwal, V., et al. Ferulic acid: A promising therapeutic phytochemical and recent patents advances [Internet]. 2019 [cited 2020 Aug 29]. Available from:

Kurikawa, Y., Togo, M., Murata, M., Matsuda, Y., Sakata, Y., Kobayashi, H., et al.Mechanistic insights into visible light-induced direct hydroxylation of benzene to phenol with air and water over pt-modified wo3 photocatalyst. Catalysts. 2020 May; 10(5):557.

Sas, O. G., Domínguez, I., González, B., Domínguez, Á. Liquid-liquid extraction of phenolic compounds from water using ionic liquids: Literature review and new experimental data using [C2mim]FSI. Journal of Environmental Management. 2018 Dec 15; 228:475-482.

Durazzo, A., Lucarini, M., Souto, E. B., Cicala, C., Caiazzo, E., Izzo, A. A., et al. Polyphenols: A concise overview on the chemistry, occurrence, and human health. Phytotherapy Research. 2019; 33(9):2221-2243.

Rothwell, J. A., Knaze, V., Zamora-Ros, R. Polyphenols: dietary assessment and role in the prevention of cancers [Internet]. 2017 [cited 2020 Aug 30]. Available from:

Zhang, H., Tsao, R. Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects. Current Opinion in Food Science. 2016 Apr; 8:33-42.

Siddiqi, R., Naz, S., Sayeed, S. A., Ishteyaque, S., Haider, M. S., Tarar, O. M., et al. Antioxidant potential of the polyphenolics in Grewia asiatica, Eugenia jambolana and Carissa carandas. Journal of Agricultural Science. 2013 Feb 17; 5(3):217.

Subramanya, M. D., Pai, S. R., Upadhya, V., Ankad, G. M., Bhagwat, S. S., Hegde, H. V. Total polyphenolic contents and in vitro antioxidant properties of eight Sida species from Western Ghats, India. Journal of Ayurveda Integrative Medicine. 2015; 6(1):24-28.

Lucarini, M., Pedulli, G. F. Free radical intermediates in the inhibition of the autoxidation reaction. Chem Soc Rev. 2010 May 25; 39(6):2106-2119.

Furia, E., Marino, T., Russo, N. Insights into the coordination mode of quercetin with the Al(III) ion from a combined experimental and theoretical study. Dalton Transactions. 2014 Apr 15; 43(19):7269-7274.

M’hiri, N., Ioannou, I., Ghoul, M., Boudhrioua, N. M. Phytochemical characteristics of citrus peel and effect of conventional and nonconventional processing on phenolic compounds: A review. Food Reviews International. 2017 Nov 2; 33(6):587-619.

Xiao, J., Ni, X., Kai, G., Chen, X. Advance in dietary polyphenols as aldose reductases inhibitors: structure-activity relationship aspect. Critical Reviews in Food Science and Nutrition. 2015 Jan 2; 55(1):16-31.

Anand, U., Jacobo-Herrera, N., Altemimi, A., Lakhssassi, N. A comprehensive review on medicinal plants as antimicrobial therapeutics: potential avenues of biocompatible drug discovery. Metabolites. 2019 Nov; 9(11):258.

Estrela, J. M., Mena, S., Obrador, E., Benlloch, M., Castellano, G., Salvador, R., et al.Polyphenolic phytochemicals in cancer prevention and therapy: bioavailability versus bioefficacy. J Med Chem. 2017 Dec 14; 60(23):9413-9436.

Abbaszadeh, H., Keikhaei, B., Mottaghi, S. A review of molecular mechanisms involved in anticancer and antiangiogenic effects of natural polyphenolic compounds. Phytotherapy Research. 2019; 33(8):2002-2014.

Hazafa, A., Rehman, K-U-, Jahan, N., Jabeen, Z. The role of polyphenol (Flavonoids) compounds in the treatment of cancer cells. Nutrition and Cancer. 2020 Apr 2; 72(3):386-397.

Harbeoui, H., Hichami, A., Wannes, W. A., Lemput, J., Tounsi, M. S., Khan, N. A. Anti-inflammatory effect of grape (Vitis vinifera L.) seed extract through the downregulation of NF-?B and MAPK pathways in LPS-induced RAW264.7 macrophages. South African Journal of Botany. 2019 Sep 1; 125:1-8.

Habyarimana, E., Dall’Agata, M., Franceschi, P. D., Baloch, F. S. Genome-wide association mapping of total antioxidant capacity, phenols, tannins, and flavonoids in a panel of Sorghum bicolor and S. bicolor × S. halepense populations using multi-locus models. PLOS ONE. 2019 dic; 14(12):e0225979.

Sousa, V., Luís, Â., Oleastro, M., Domingues, F., Ferreira, S. Polyphenols as resistance modulators in Arcobacter butzleri. Folia Microbiol. 2019 Jul 1; 64(4):547-554.

Cardoso, R. R., Neto, R. O., dos Santos D’Almeida, C. T., do Nascimento, T. P., Pressete, C. G., Azevedo, L., et al.Kombuchas from green and black teas have different phenolic profile, which impacts their antioxidant capacities, antibacterial and antiproliferative activities. Food Research International. 2020 Feb 1; 128:108782.

Callcott, E. T., Blanchard, C. L., Snell, P., Santhakumar, A. B. The anti-inflammatory and antioxidant effects of pigmented rice consumption in an obese cohort. Food and Function. 2019; 10(12):8016-8025.

Hurtado-Barroso, S., Martínez-Huélamo, M., De Alvarenga, JFR., Quifer-Rada, P., Vallverdú-Queralt, A., Pérez-Fernández, S., et al.Acute effect of a single dose of tomato sofrito on plasmatic inflammatory biomarkers in healthy men. Nutrients. 2019; 11(4).

Kodarahmian, M., Amidi, F., Moini, A., Kashani, L., Shabani Nashtaei, M., Pazhohan, A., et al.The modulating effects of Resveratrol on the expression of MMP-2 and MMP-9 in endometriosis women: a randomized exploratory trial. Gynecological Endocrinology. 2019; 35(8):719-726.

Jakobek, L. Interactions of polyphenols with carbohydrates, lipids and proteins. Food Chemistry. 2015 May 15; 175:556-567.

Eran Nagar, E., Okun, Z., Shpigelman, A. Digestive fate of polyphenols: updated view of the influence of chemical structure and the presence of cell wall material. Current Opinion in Food Science. 2020 Feb 1; 31:38-46.

Tian, L., Tan, Y., Chen, G., Wang, G., Sun, J., Ou, S., et al. Metabolism of anthocyanins and consequent effects on the gut microbiota. Critical Reviews in Food Science and Nutrition. 2019 Mar 26; 59(6):982-991.

Kumar, N., Goel, N. Phenolic acids: Natural versatile molecules with promising therapeutic applications. Biotechnology Reports. 2019 Dec 1; 24:e00370.

Rakers, C., Schwerdtfeger, S. M., Mortier, J., Duwe, S., Wolff, T., Wolber, G., et al. Inhibitory potency of flavonoid derivatives on influenza virus neuraminidase. Bioorganic and Medicinal Chemistry Letters. 2014; 24(17):4312-4317.

Zima, V., Radilová, K., Kožíšek, M., Albiñana, C. B., Karlukova, E., Brynda, J., et al.Unraveling the anti-influenza effect of flavonoids: experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors. European Journal of Medicinal Chemistry. 2020 Aug 22; 112754.

Ciesek, S., von Hahn, T., Colpitts, C. C., Schang, L. M., Friesland, M., Steinmann, J., et al. The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry. Hepatology. 2011; 54(6):1947-1955.

Chowdhury, P., Sahuc, M. E., Rouillé, Y., Rivière, C., Bonneau, N., Vandeputte, A., et al. Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus in cell culture. PLoS ONE. 2018; 13(11).

Carneiro, B. M., Batista, M. N., Braga, ACS, Nogueira, M. L., Rahal, P. The green tea molecule EGCG inhibits Zika virus entry. Virology. 2016; 496:215-218.

Lu, J. W., Hsieh, P. S., Lin, C. C., Hu, M. K., Huang, S. M., Wang, Y. M., et al. Synergistic effects of combination treatment using EGCG and suramin against the chikungunya virus. Biochemical and Biophysical Research Communications. 2017; 491(3):595-602.

Zhang, L. L., Zhang, L. F., Xu, J. G. Chemical composition, antibacterial activity and action mechanism of different extracts from hawthorn (Crataegus pinnatifida Bge.). Scientific Reports. 2020; 10(1):1-13.

Xiao, J., Muzashvili, T. S., Georgiev, M. I. Advances in the biotechnological glycosylation of valuable flavonoids. Biotechnology Advances. 2014; 32(6):1145-1156.

Di Ferdinando, M., Brunetti, C., Agati, G., Tattiani, M. Multiple functions of polyphenols in plants inhabiting unfavorable Mediterranean areas. Nutrición Hospitalaria. 2013; 28(1):36-46.




How to Cite

Cano-Avendaño BA, Carmona-Hernandez JC, Rodriguez RE, Taborda-Ocampo G, González-Correa CH. Chemical properties of polyphenols: a reviewfocusedonanti-inflammatory and anti-viral medical application. Biomedicine [Internet]. 2021Apr.3 [cited 2021Apr.14];41(1):3-8. Available from: