Comparison of serum nitric oxide levels with case severity in pre-eclampsia – A case control study


  • Kashinakunti Sangappa Virupaxappa
  • Basavaraj Devaranavadagi
  • Basavaraj Devaranavadagi
  • Manjula Rangappa
  • Mallapur Ashalata



Nitric oxide, pre-eclampsia, birth weight, APGAR score


Introduction and Aim: In preeclampsia(PE) due to abnormal trophoblastic invasion of the maternal spiral arteries leads to decreased uteroplacental circulation. Nitric oxide (NO) is involved in regulation offeto-placental vascular permeability and resistance. It also affects maturation, development of the placenta and foetal survival. Maternal serum NO levels are controversial in PEandonly few studies have focused on birth outcomes. Hence, the current study was undertaken to estimate and compare the maternal serum NOlevels in normal pregnant and PE womenandalso see the correlation betweenmaternal serum NO level with severity of PEand to study its association with birth outcome.

Materials and Methods:The study was conductedat a tertiary care hospital in North Karnataka, India.Forty singleton primigravida PE patients diagnosed and classified as mild/severePE, as per ACOG guidelines and 40 healthy pregnant were selected for the study. NO was estimated by ELISA method.

Results: NO was high in PE cases than controls but it was not statistically significant. But NO was significantly (p=0.03) higher in mild PE than severe PE patients. The NO level negatively correlated significantly (p=0.031) with case severity. Maternal serum NO did not show any significant correlation with birth weight and APGAR score of the new born baby.

Conclusion:In mild PE rise in maternal serum NO, may be to due compensatory mechanism to normalise persistently elevated blood pressure and decreased level of serum NO in severe PE may be due to down-regulation of the nitric oxide synthase.

Author Biographies

Kashinakunti Sangappa Virupaxappa

Department of Biochemistry, Shri B M Patil Medical College, BLDE  University, Vijayapur, Karnataka, India

Basavaraj Devaranavadagi

Nijalingappa Medical College, Navanagar, Bagalkot 587102, Karnataka, India

Basavaraj Devaranavadagi

Department of Biochemistry, Shri B M Patil Medical College, BLDE  University, Vijayapur, Karnataka, India

Manjula Rangappa

Nijalingappa Medical College, Navanagar, Bagalkot 587102, Karnataka, India

Mallapur Ashalata

Department of Obstetrics and Gynaecology, S. Nijalingappa Medical College, Navanagar, Bagalkot 587102, Karnataka, India


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How to Cite

Sangappa Virupaxappa K, Devaranavadagi B, Devaranavadagi B, Rangappa M, Ashalata M. Comparison of serum nitric oxide levels with case severity in pre-eclampsia – A case control study. Biomedicine [Internet]. 2021Apr.3 [cited 2021Apr.14];41(1):42-5. Available from:



Original Research Articles