Assessment of carotid artery intima media thickness in prehypertension


  • Anahita R. Shenoy Basti
  • M Shrilakshmi
  • Ram Shenoy Basti



Prehypertension, carotid artery intima media thickness, atherosclerosis, blood pressure


Introduction and Aim: Increased carotid artery intima media thickness (CIMT) has been linked to the development of cardiovascular disease (CVD). CVD is a major cause of mortality and morbidity in India. Increased CIMT has been documented in Hypertension (HT), thus putting them at a higher risk of CVD. Early identification and awareness of risk factors leading to increased morbidity and mortality could help in reducing its incidence. The aim of the study was to measure CIMTin prehypertensive Indian population.


Materials and Methods:In this analytical observational study, common carotid artery IMT was measured using B mode ultrasonography in 46 individuals having blood pressure in the prehypertensive range and 46 individuals with normal blood pressure. Cardiovascular risk factors like body mass index(BMI),fasting blood glucose (FBS), and lipid profile, which are known to influence CIMT,were also assessed and compared between the two groups.


Results:CIMT was significantly higher in prehypertensives as compared to subjects having normal blood pressure. BMI, FBS, and lipid profile was found to be comparable between the two groups.


Conclusions:The presence of increased CIMT in prehypertensives as compared to controls indicates an increased risk of adverse cardiovascular events.

Author Biographies

Anahita R. Shenoy Basti

Department of Physiology,   Father Muller Medical College, Mangalore - 575002, Karnataka India

M Shrilakshmi

Department of Medicine,  Father Muller Medical College, Mangalore - 575002, Karnataka India

Ram Shenoy Basti

Professor, Department of Radiology, Father Muller Medical College, Mangalore575002, Karnataka India


Stein, J.H., Korcarz, C.E., Hurst, R.T., Lonn, E., Kendall, C.B., Mohler, E.R., et al., Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: A consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine. J Am SocEchocardiogr.2008; 21:93-111.

Takase, H., Sugiura, T., Murai, S., Yamashita, S., Ohte, N., Dohi, Y. Carotid intima-media thickness is a novel predictor of new onset of hypertension in normotensive subjects. Medicine (Baltimore)2017;96(31): e7710.

Efstathios, M., Geogios, T., Eleni, K., Kinmon, S., Christos, P., Savas, T.,et al., Impact of prehypertension on common carotid artery intima-media thickness and left ventricular mass. Stroke.2009; 40:1515-1518.

Toikka, J.O., Laine, H., Ahotupa, M., Haapanen, A., Viikari, J.S., Hartiala, J.J., Raitakari, O.T., Increased arterial intima-media thickness and in vivo LDL oxidation in young men with borderline hypertension. Hypertension 2000; 36:929-933.

Petar,N., Julia,N., Tanya,D., Fedya,N., Changes in intima media thickness, ankle brachial index and flow mediated dilation in pre hypertensive individuals. Scriptascientificamedica. 2015;47(3): 15-20.

Chobanian, A.V., Bakris, G.L., Black, H.R., Cushman, W.C., Green, L.A., Izzo, J.L.,et al., The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA. 2003;289(19):2560-2572.

Parthaje, P.M., Unnikrishnan, B., Thankappan, K.R., Thapar, R., Fatt, Q.K., Oldenburg, B. Prevalence and correlates of prehypertension among adults in Urban South India. Asia Pac J Public Health. 2016;28(1Suppl):93S–101S.

Mini, G.K., Sarma, P.S., Thankappan, K.R., Risk of progression to hypertension from prehypertension and normal blood pressure: Results from a prospective cohort study among industrial workers in Kerela, India. Heart Mind 2018; 2:106-110.

Han, M., Li, Q., Liu, L., Zhang, D., Ren, Y., Zhao, Y., et al., Prehypertension and risk of cardiovascular diseases: a meta-analysis of 47 cohort studies. J Hypertens.2019;37(12):2325-2332.

Mainous,A.G., Everett, C.J., Liszka, H., King, D.E., Egan, B.M., Prehypertension and mortality in a nationally representative cohort. Am J Cardiol. 2004;94(12):1496-1500.

Urbina, E.M., Khoury, P.R., McCoy, C., Daniels, S.R., Kimball, T.R., Dolan, L.M. Cardiac and vascular consequences of prehypertension in youth. J ClinHypertens. 2011; 13:332-342.

Kim, S.H., Cho, G.Y., Baik, I., Lim, S.Y., Choi, C.U., Lim, H.E.,et al.,Early abnormalities of cardiovascular structure and function in middle aged Korean adults with pre-hypertension: The Korean Genome Epidemiology Study. Am J Hypertens. 2011; 24:218-224.

Liu,B., Ni, J., Shi,M., Zhan, C., Lu, H., Wu,Y.,et al., Carotid intima-media thickness and its association with conventional risk factors in low-income adults: a population-based cross-sectional study in China. Sci Rep.2017; 7:41500.

Jacoby, D.S., Mohler, I.E., Rader, D.J.,Noninvasive atherosclerosis imaging for predicting cardiovascular events and assessing therapeutic interventions. CurrAtheroscler Rep. 2004; 6:20-26.

Hansa, G., Bhargava, K., Bansal, M., Tandon, S., Kasliwal, R.R.,Carotid intima media thickness and coronary artery disease: An Indian perspective. Asian CardiovascThorac Ann. 2003; 11:217-221.

Whelton, P.K., Carey, R.M., Aronow, W.S., Casey, D.E., Collins, K.J., Himmelfarb, C.D.,et al., 2017 ACC/AHA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am CollCardiol. 2018;71: e127-e248.

Zhang, M., Batu, B., Tong, W., Li, H., Lin, Z., Li, Y., et al., Prehypertension and cardiovascular risk factor clustering among Mongolian population in rural and animal husbandry area, Inner Mongolia, China. Circ J. 2009; 73:1437-1441.

Lankarani, K.B., Ghaffarpasand, F., Mahmoodi, M., Dehghankhalili, M., Honarvar, B., Lotfi, M., et al., Predictors of common carotid artery intima-media thickness and atherosclerosis in a sample of Iranian general population. Shiraz E-Med J. 2015;16(5): e27906.

Yadav, S., Boddula, R., Genitta, G., Bhatia, V., Bansal, B., Kongara, S., et al.,Prevalence and risk factors of pre-hypertension and hypertension in an affluent north Indian population. Indian J Med Res. 2008; 128:712-720.

Mohan, V., Deepa, M., Farooq, S., Datta, M., Deepa, R., Prevalence, awareness and control of hypertension in Chennai—The Chennai Urban Rural Epidemiology Study (CURES-52). J Assoc Physicians India. 2007; 55:326–332.

Cuspidi, C., Sala, C., Tadic, M., Gherbesi, E., Grassi, G., Mancia, G. Pre-hypertension and subclinical cardiac damage: A meta-analysis of echocardiographic studies. Int J Cardiol. 2018; 270:302-308.

De Marco, M., de Simone, G., Roman, M.J., Chinali, M., Lee, E.T., Russell, M.,et al., Cardiovascular and metabolic predictors of progression of prehypertension into hypertension: the Strong Heart Study. Hypertension 2009;54(5):974-980.

Salonen, J.T., Salonen, R. Ultrasound B-mode imaging in observationalstudies of atherosclerotic progression. Circulation. 1993;87: II56-65.




How to Cite

Shenoy Basti AR, Shrilakshmi M, Shenoy Basti R. Assessment of carotid artery intima media thickness in prehypertension. Biomedicine [Internet]. 2021Apr.3 [cited 2021Apr.14];41(1):88-92. Available from:



Original Research Articles