Association of serum adenosine deaminase level with atherosclerotic index in type 2 diabetes mellitus patients


  • M Rasheed Khan
  • S Vinod Babu
  • V. KuzhandaiVelu



ADA, atherosclerotic index, T2DM, lipid profile


Introduction and Aim:The atherosclerosis is the major cause of morbidity and mortality among diabetes population. Diabetes mellitus can accelerate atherosclerotic processes. Adenosine deaminase (ADA) plays a significant role in both glucose and lipid metabolism through adenosine. This study aimed to correlate the atherosclerotic index with adenosine deaminase levels in Type 2 diabetes mellitus patients. The aim of the study is to find the association between serum ADA levels with atherosclerotic index.


Materials and Methods: A cross sectional study conducted in 100 subjects (50 control and 50 T2DM patients). The following biochemical parameter were estimated:total cholesterol, triacylglycerol, HDL- C and ADA. VLDL, LDL and other atherosclerotic index were calculated using formulae. Statistical analysis such as Student’s‘t’ test and Pearson’s correlation were performed.


Results: We found significant increase (p value <0.001) in lipid profile, Non-HDL-C and lipid ratio when compared to T2DM with control group. The correlation of serum ADA with lipid profile and lipid ratio didnot show any correlation.


Conclusion: Serum ADA used as a biomarker for evaluation of glycemic status. ADA was insignificant, when correlated with dyslipidemia and atherosclerotic index.

Author Biographies

M Rasheed Khan

Department of Biochemistry, Trichy SRM Medical College, Hospital and Research

Centre, Irungalur, Trichy, 621105, Tamil Nadu, India

S Vinod Babu

Departmentof Biochemistry, Mahatma Gandhi, Medical College and Research Institute, SBV, Pillaiyarkuppam, 607 402, Pondicherry,India

V. KuzhandaiVelu

Departmentof Biochemistry, Mahatma Gandhi,  Medical College and Research Institute, SBV, Pillaiyarkuppam, 607 402, Pondicherry,India


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How to Cite

Rasheed Khan M, Vinod Babu S, KuzhandaiVelu V. Association of serum adenosine deaminase level with atherosclerotic index in type 2 diabetes mellitus patients. Biomedicine [Internet]. 2021Apr.3 [cited 2021Apr.14];41(1):150-2. Available from:



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