Association of serum adenosine deaminase level with atherosclerotic index in type 2 diabetes mellitus patients
Keywords:ADA, atherosclerotic index, T2DM, lipid profile
Introduction and Aim:The atherosclerosis is the major cause of morbidity and mortality among diabetes population. Diabetes mellitus can accelerate atherosclerotic processes. Adenosine deaminase (ADA) plays a significant role in both glucose and lipid metabolism through adenosine. This study aimed to correlate the atherosclerotic index with adenosine deaminase levels in Type 2 diabetes mellitus patients. The aim of the study is to find the association between serum ADA levels with atherosclerotic index.
Materials and Methods: A cross sectional study conducted in 100 subjects (50 control and 50 T2DM patients). The following biochemical parameter were estimated:total cholesterol, triacylglycerol, HDL- C and ADA. VLDL, LDL and other atherosclerotic index were calculated using formulae. Statistical analysis such as Student’s‘t’ test and Pearson’s correlation were performed.
Results: We found significant increase (p value <0.001) in lipid profile, Non-HDL-C and lipid ratio when compared to T2DM with control group. The correlation of serum ADA with lipid profile and lipid ratio didnot show any correlation.
Conclusion: Serum ADA used as a biomarker for evaluation of glycemic status. ADA was insignificant, when correlated with dyslipidemia and atherosclerotic index.
Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2009 Jan;32(Suppl 1):S62-S67.
Ramachandran, A., Snehalatha, C., Kapur, A., Vijay, V., Mohan, V., Das, A. K., et al., High prevalence of diabetes and impaired glucose tolerance in India: National Urban Diabetes Survey. Diabetologia. 2001 Sep;44(9):1094-1101.
Shrivastava, S. R., Ghorpade, A. G. High prevalence of type 2 diabetes melitus and its risk factors among the rural population of Pondicherry, South India. J Res Health Sci. 2014 Jan 11;14(4):258-263.
Kumar, P., Mallik, D., Mukhopadhyay, D. K., Sinhababu, A., Mahapatra, B. S., Chakrabarti, P. Prevalence of diabetes mellitus, impaired fasting glucose, impaired glucose tolerance, and its correlates among police personnel in Bankura district of west Bengal. Indian J Public Health. 2013 Jan 1;57(1):24.
Martín-Timón I. Type 2 diabetes and cardiovascular disease: Have all risk factors the same strength? World J Diabetes. 2014;5(4):444.
Ridker, P. M. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation. 2003 Jan 28;107(3):363-369.
Fu, Y., Wu, Y., Liu, E. C?reactive protein and cardiovascular disease: From animal studies to the clinic (Review). Exp Ther Med. 2020 Jun 4;20(2):1211-1219.
Sapkota, L. B., Thapa S, Subedi N. Correlation study of adenosine deaminase and its isoenzymes in type 2 diabetes mellitus. BMJ Open Diabetes Res Care. 2017 Mar;5(1):e000357.
Hariprasath, G., Ananthi, N. Glycemic control and raised adenosine deaminase activity in type 2 diabetes mellitus. IOSR J Dent Med Sci. 2017 Jan;16(01):53-56.
Patel, B., Taviad, D., Malapati, B., Chhatriwala, M., Shah, R. Serum adenosine deaminase in patients with type-2 diabetes mellitus and its relation with blood glucose and glycated haemoglobin levels. Int J Biomed Res. 2014 Sep 30;5(9):556.
Singh, P., Khan, S., Rabindra Kumar, M. Adenosine deaminase activity and its relation with glycated hemoglobin and uric acid in type 2 diabetic patients. IJDO. 2013 Jan 1;5(1):1-6.
Niraula, A., Thapa, S., Kunwar, S., Lamsal, M., Baral, N., Maskey, R. Adenosine deaminase activity in type 2 diabetes mellitus: does it have any role? BMC Endocr Disord. 2018 Aug 20;18(1):58.
Lee, J-G., Kang, D. G., Yu, J. R., Kim, Y. R., Kim, J. S., Koh, G. P., et al. Changes in adenosine deaminase activity in patients with type 2 diabetes mellitus and effect of dpp-4 inhibitor treatment on ada activity. Diabetes Metab J. 2011;35(2):149.
Wu, C-J., Yu, Z-R. Effects on blood glucose, insulin, lipid and proatherosclerotic parameters in stable type 2 diabetic subjects during an oral fat challenge. Lipids Health Dis. 2004;3(1):17.
Hoshino, T., Yamada, K., Masuoka, K., Tsuboi, I., Itoh, K., Nonaka, K., et al. Elevated adenosine deaminase activity in the serum of patients with diabetes mellitus. Diabetes Res Clin Pract. 1994 Sep;25(2):97-102.
Larijani, B., Heshmat, R., Ebrahimi-Rad, M., Khatami, S., Valadbeigi, S., Saghiri, R. Diagnostic value of adenosine deaminase and its isoforms in type 2 diabetes mellitus. Enzyme Res. 2016; 2016:1-6.
Mills, S. E. Regulation of porcine adipocyte metabolism by insulin and adenosine. J Anim Sci. 1999;77(12):3201.
How to Cite
This work is licensed under a Creative Commons Attribution 4.0 International License.