Effect of bortezomib on fatty liver in a rat model of atherosclerosis





atherosclerosis, bortezomib, fatty liver, interleukin-6, proteasome


Introduction and Aim: Fatty liver is associated with atherosclerosis even though the exact mechanism remains unknown. Fatty liver and atherosclerosis correlate with inflammation. Interleukin 6 (IL-6) is recognized as an inflammatory marker. Bortezomib is a proteasome inhibitor that will inhibit the proteasome pathway and is expected to inhibit inflammation in atherosclerosis. The current research aimed to investigate the effect of bortezomib on the fatty liver of atherosclerosis rats and to analyze its correlation with serum IL-6 concentration.


Materials and Methods: Experimental subjects were 18 male Wistar rats (Rattus novergicus) divided into three treatment groups, namely atherosclerosis group (I), atherosclerosis + bortezomib group (II), and control group (III). Bortezomib (50 ?g/kg BW) was given twice intraperitoneally, on day 1 and day 3. The presence of fatty liver was evaluated using the percentage system. Serum IL-6 concentrations were measured using enzyme-linked immunosorbent assay kits.


Results: The highest amount of fatty liver was found in the atherosclerosis group (group I) (38.33%), while the lowest was in the control group (group III) (5.83%). There was a decreasing fatty liver percentage due to bortezomib administration (group II) (29.17%), and it was statistically significant. There is a significant correlation between the degree of fatty liver and serum IL-6 concentration.


Conclusion: The administration of bortezomib 50 ?g/kg BW in atherosclerosis model rats can reduce the occurrence of fatty liver by reducing the inflammatory process.

Author Biographies


Department of Biochemistry, Riau University, Jl.Diponegoro No. 1, Pekanbaru 28133, Indonesia

Ilhami Romus

Department of Pathology & Anatomy,  Riau University, Jl.Diponegoro No. 1, Pekanbaru 28133, Indonesia

Enikarmila Asni

Department of Biochemistry, Riau University, Jl.Diponegoro No. 1, Pekanbaru 28133, Indonesia

Rini Aprililia Purwanti

Faculty of Medicine, Riau University, Jl.Diponegoro No. 1, Pekanbaru 28133, Indonesia

Syarifah Fathurrahmah

Faculty of Medicine, Riau University, Jl.Diponegoro No. 1, Pekanbaru 28133, Indonesia


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How to Cite

Ismawati, Romus I, Asni E, Purwanti RA, Fathurrahmah S. Effect of bortezomib on fatty liver in a rat model of atherosclerosis. Biomedicine [Internet]. 2022 May 1 [cited 2022 Nov. 27];42(2):256-61. Available from: https://biomedicineonline.org/home/article/view/561



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