PD-L1 expression in gastric carcinoma – a biomarker for immunotherapy

Authors

  • Dhanya Menon
  • Ganthimathy Sekhar

DOI:

https://doi.org/10.51248/.v42i2.707

Keywords:

PD-L1, gastric cancer, checkpoint inhibitor, immunotherapy

Abstract

Introduction and Aim: Immunotherapy is now being widely used for targeted therapy in several cancers. The PD-1/ PD-L1 (programmed cell death receptor/programmed cell death ligand) axis inhibits the expansion of tumour specific T cells and prevents the immune response against tumours. PD-L1 expression is seen in many cancers including gastric carcinomas and anti PDL1 antibodies are being used to produce tumour regression. This study was done to evaluate PD-L1 expression in gastric carcinomas and correlate this with the different histological types, grades and stages of these tumours

 

Materials and Methods: In this study, 50 cases of gastric adenocarcinoma were analysed for PD-L1 expression using immunohistochemistry. PD-L1 expression was correlated with histopathological factors including histological type, differentiation, grade and stage using statistical methods.

 

Results: A positive PD-L1 expression was observed in 52% of the cases. A positive correlation between PD-L1 positivity and tumour depth to which the tumour was invading the stomach was observed. No correlation was noted with expression of PD-L1 and histological type, differentiation, histological grade and presence/absence of nodal metastasis.

 

Conclusion: PD-L1 expression was seen in more than half of the patients in our study. Hence it is suggested that anti PD-L1 inhibitors can be used as an adjunct in the treatment of gastric cancers, especially those with a greater depth of invasion.

Author Biographies

Dhanya Menon

Department of Pathology, Saveetha Medical College and Hospital, Saveetha Nagar, Thandalam, Chennai 602105, Tamil Nadu, India

Ganthimathy Sekhar

Department of Pathology, Saveetha Medical College and Hospital, Saveetha Nagar, Thandalam, Chennai 602105, Tamil Nadu, India

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Published

2022-05-01

How to Cite

1.
Menon D, Sekhar G. PD-L1 expression in gastric carcinoma – a biomarker for immunotherapy. Biomedicine [Internet]. 2022 May 1 [cited 2022 Nov. 27];42(2):383-7. Available from: https://biomedicineonline.org/home/article/view/707

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