Quorum sensing related activity of Aggregatibacter actinomycetemcomitans in periodontal disease: A review

Authors

  • Haswati Nurhayati Abdullah
  • Suharni Mohamad
  • Wan Rohani WanTaib
  • Norzawani Jaffar

DOI:

https://doi.org/10.51248/.v41i2.778

Keywords:

Aggregatibacter actinomycetemcomitans, biofilm, periodontal disease, quorum sensing, auto-inducer

Abstract

Aggregatibacter actinomycetemcomitans is a significant pathogen in periodontal disease, contributing to aggressive and chronic inflammatory conditions of the periodontal area. This pathogen is shown to contribute to the tenacious biofilm formation in the oral cavity and results in persistent induction of pro-inflammatory response leads to progressive periodontitis. Besides the immune-modulatory capabilities, quorum sensing (QS) activity is believed to influence the virulence activities, leading to a progressive inflammatory response by the host. QS modulates the expression of genes involved in the processes related to survival and biofilm formation activities by answering the localized bacterial population's fluctuation. Understanding the QS activity of this pathogen and its impact on disease might be useful as an alternative approach to counteract the infection. Therefore, this review paper is focusing on the evaluation of the QS activities of A. actinomycetemcomitans and how this activity influences the progression of periodontal disease. Based on the previous findings, we found that there are possibilities the QS activity interrupted by enzymes or molecules that blocking the QS signals produced by other species of bacteria. However, due to minimal QS studies that have been done specifically on A. actinomycetemcomitans, the mechanism is not conclusive. Therefore, this might initiate an essential option for alternative treatment against periodontal pathogen infection and oral health care.

Author Biographies

Haswati Nurhayati Abdullah

  1. Faculty of Health Sciences, Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Terengganu, Terengganu, Malaysia,
  2. School of Dental Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia

 

Suharni Mohamad

School of Dental Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia

Wan Rohani WanTaib

Faculty of Health Sciences, Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Terengganu, Terengganu, Malaysia

Norzawani Jaffar

School of Dental Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia

References

Nazir, M.A. Prevalence of periodontal disease, its association with systemic diseases and prevention. Int J Heal Sci [Internet]. 2017;11(2):72-80. Available from: https://www.ncbi.nlm.nih.gov/pubmed/28539867

Newman, M.G., Socransky, S.S., Savitt, E.D., Propas, D.A. Crawford A. Studies of the microbiology of periodontosis. J Periodontol. 1976;47:373-379.

Triantafyllia, V., Georgios, T.Periodontal diseases in children and adolescents affected by systemic disorders - a literature review. Int J Oral Dent Heal [Internet]. 2018; Available from: https://clinmedjournals.org/articles/ijodh/international-journal-of-oral-and-dental-health-ijodh-4-055.pdf

Mahdizade-ari, M., Pourhajibagher, M., Bahador, A. Changes of microbial cell survival, metabolic activity, efflux capacity, and quorum sensing ability of Aggregatibacteractinomycetemcomitans due to antimicrobial photodynamic therapy-induced bystander effects. PhotodiagnosisPhotodynTher [Internet]. 2019; Available from: https://pubmed.ncbi.nlm.nih.gov/31026616/

Nørskov-Lauritsen, N., Kilian, M. Reclassification of Actinobacillusactinomycetemcomitans, Haemophilusaphrophilus, Haemophilusparaphrophilus and Haemophilussegnis as Aggregatibacteractinomycetemcomitans gen. nov., comb. nov., Aggregatibacteraphrophilus comb. nov. and Aggregatibacter. Int J Syst Evol Microbiol [Internet]. 2006;56(9):2135-2146. Available from: https://pubmed. ncbi.nlm.nih.gov/16957111/

Perry, M.B., Maclean, L.M., Brisson, J.R., Wilson, M.E. Structures of the antigenic O-polysaccharides of lipopolysaccharides produced by Actinobacillusactinomycetemcomitans serotypes a, c, d and e. Eur J Biochem [Internet]. 1996;242(3):682-688. Available from: https://febs.onlinelibrary.wiley.com/doi/full/10.1111/j.1432-1033.1996.0682r.x

Höglund-Åberg, C., Haubek, D., Kwamin, F., Johansson, A., Claesson, R. Leukotoxic activity of Aggregatibacteractinomycetemcomitans and periodontal attachment loss. PLoS One. 2014;9(8).

Li, Y., Shibata, Y., Zhang, L., Kuboyama, N., Abiko, Y. Periodontal pathogen AggregatibacteractinomycetemcomitansLPS induces mitochondria-dependent-apoptosis in human placental trophoblasts. Placenta. 2011;32(1):11-19.

Sosroseno, W., Bird, P.S., Seymour, G.J. Nitric oxide production by a human osteoblast cell line stimulated with Aggregatibacteractinomycetemcomitans lipopolysaccharide. Oral Microbiol Immunol. 2009;24(1):50-55.

Aida, Y., Kukita, T., Takada, H., Maeda, K., Pabst, M.J. Lipopolysaccharides from periodontal pathogens prime neutrophils for enhanced respiratory burst: differential effect of a synthetic lipid a Precursor IVA(LA?14?PP). J Periodontal Res [Internet]. 1995; Available from: https://pubmed.ncbi.nlm.nih.gov/7539837/

March, J. C., Bentley, W. E. Quorum sensing and bacterial cross-talk in biotechnology. CurrOpinBiotechnol [Internet]. 2004;15(5):495-502. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0958166904001193?via%3Dihub

Plan?ak, D., Musi?, L., Puhar, I. Quorum sensing of periodontal pathogens. Acta Stomatol Croat [Internet]. 2015; Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993591/

Papenfort, K., Bassler, B.L. Quorum sensing signal-response systems in Gram-negative bacteria [Internet]. Nature Reviews Microbiology 2016 p. 576-588. Available from: https://www.nature.com/articles/nrmicro.2016.89

Bassler, B.L. How bacteria talk to each other: Regulation of gene expression by quorum sensing [Internet]. Current Opinion in Microbiology. 1999. Available from: https://www.sciencedirect.com/science/article/abs/pii/S1369527499000259?via%3Dihub

Bassler, B.L., Losick, R. Bacterially speaking. Cell [Internet]. 2006;125(2):237-246. Available from: https://www.ncbi.nlm.nih.gov/pubmed/16630813

Verbeke, F., De, C.S., Debunne, N., Janssens, Y., Wynendaele, E., Van-de, W.C.et al., Peptides as quorum sensing molecules: Measurement techniques and obtained levels in vitro and in vivo [Internet]. Frontiers in Neuroscience. 2017. Available from: https://www.frontiersin.org/articles/10.3389/fnins.2017.00183/full

Sudheer, Y., Kamalesh, B., Siddharth, S., Indra, G., Swetha, R.K. Quorum sensing inhibition, relevance to periodontics. J Int Oral Heal [Internet]. 2015;7:67-69. Available from: https://www.researchgate.net/publication/272843218_Quorum_Sensing_Inhibition_Relevance_to_Periodontics

Antunes, L.C.M., Ferreira, R.B.R., Buckner, M.M.C., Finlay, B.B. Quorum sensing in bacterial virulence [Internet]. Microbiology. 2010. Available from: https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.038794-0#tab2

Bachtiar, E.W., Bachtiar, B.M., Jarosz, L.M., Amir, L.R., Sunarto, H., Ganin, H.et al., AI-2 of Aggregatibacteractinomycetemcomitansinhibits Candida albicans biofilm formation. Front Cell Infect Microbiol [Internet]. 2014 [cited 2020 Aug 5];4(JUL):1-8. Available from: https://www.frontiersin.org/articles/10.3389/fcimb.2014.00094/full

Fong, K.P., Chung, W.O., Lamont, R.J., Demuth, D.R. Intra- and interspecies regulation of gene expression by ActinobacillusactinomycetemcomitansLuxS. Infect Immun. 2001.

Frias, J., Olle, E., Alsina, M. Periodontal pathogens produce quorum sensing signal molecules. Infect Immun [Internet]. 2001; Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC98305/

Szymon, P.S., Zhi-Luo, D., Jurgen, T., Michael, J., Sabin, B., Manfred, R., Helena, S., Irene, W-D. Quorum sensing of Streptococcus mutans is activated by Aggregatibacteractinomycetemcomitans and by the periodontal microbiome. BMC Genomics [Internet]. 2017 Mar 20 [cited 2021 Jan 26];18(1). Available from: https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-3618-5

Fong, K.P., Gao, L., Demuth, D.R. luxS and arcB control aerobic growth of Actinobacillusactinomycetemcomitansunder iron limitation. Infect Immun [Internet]. 2003;71(1):298-308. Available from: https://www.ncbi.nlm.nih.gov/pubmed/12496179

Shao, H., Lamont, R.J., Demuth, D.R. Autoinducer 2 is required for biofilm growth of Aggregatibacter (Actinobacillus) actinomycetemcomitans. Infect Immun [Internet]. 2007;75(9):4211-4218. Available from: https://www.ncbi.nlm.nih.gov/pubmed/17591788

Novak, E.A., Shao, H.J., Daep, C.A., Demuth, D.R. Autoinducer-2 and QseC control biofilm formation and in vivo virulence of Aggregatibacteractinomycetemcomitans. Infect Immun [Internet]. 2010 [cited 2021 Jan 26];78(7):2919-2926. Available from: https://iai.asm.org/content/78/7/2919

Bachtiar, E.W., Bachtiar, B.M. Effect of cell?free spent media prepared from Aggregatibacteractinomycetemcomitans on the growth of Candida albicans and Streptococcus mutans in co?species biofilms. Eur J Oral Sci [Internet]. 2020; Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/eos.12725

Juárez-Rodríguez, M.D., Torres-Escobar, A., Demuth, D.R. ygiW and qseBC are co-expressed in Aggregatibacteractinomycetemcomitansand regulate biofilm growth. Microbiol (United Kingdom) [Internet]. 2013; Available from: https://pubmed.ncbi.nlm.nih.gov/23519160/

Weigel, W.A., Demuth, D.R. QseBC, a two-component bacterial adrenergic receptor and global regulator of virulence in Enterobacteriaceae and Pasteurellaceae. Molecular Oral Microbiology. 2016.

James, D., Shao, H., Lamont, R.J., Demuth, D.R. The Actinobacillusactinomycetemcomitans ribose binding protein RbsB interacts with cognate and heterologous autoinducer 2 signals. Infect Immun [Internet]. 2006;74(7):4021-4029. Available from: https://www.ncbi.nlm.nih.gov/pubmed/16790775

Flemming, H.C., Neu, T.R., Wozniak, D.J. The EPS matrix: the “house of biofilm cells.” J Bacteriol [Internet]. 2007;189(22):7945–7. Available from: https://www.ncbi.nlm.nih.gov/pubmed/17675377

Frederick, M.R., Kuttler, C., Hense, B. A., Eberl, H.J. A mathematical model of quorum sensing regulated EPS production in biofilm communities. Theor Biol Med Model. 2011;8(1):1-29.

Monroe, D. Looking for chinks in the armor of bacterial biofilms. PLoS Biol [Internet]. 2007;5(11):e307. Available from: https://www.ncbi.nlm.nih.gov/pubmed/18001153

Zhang, W., Li, C. Exploiting quorum sensing interfering strategies in gram-negative bacteria for the enhancement of environmental applications. Front Microbiol. 2016;

Kolenbrander, P.E., Andersen, R.N., Blehert, D.S., Egland, P.G., Foster, J.S., Palmer, Jr. R.J. Communication among oral bacteria. Microbiol Mol Biol Rev [Internet]. 2002;66(3):486–505. Available from: https://www.ncbi.nlm.nih.gov/pubmed/12209001

Nyvad, B., Kilian, M. Microbiology of the early colonization of human enamel and root surfaces in vivo. Scand J Dent Res [Internet]. 1987;95(5):369–80. Available from: https://www.ncbi.nlm.nih.gov/pubmed/3477852

Chandki, R., Banthia, P., Banthia, R. Biofilms: A microbial home. J Indian Soc Periodontol [Internet]. 2011;15(2):111–4. Available from: https://www.ncbi.nlm.nih.gov/pubmed/21976832

Socransky, S.S., Haffajee, A.D. Dental biofilms: difficult therapeutic targets. Periodontol 2000 [Internet]. 2002;28:12-55. Available from: https://www.ncbi.nlm.nih.gov/pubmed/12013340

Ryu, E.J., Sim, J., Sim, J., Lee, J., Choi, B.K. D-Galactose as an autoinducer 2 inhibitor to control the biofilm formation of periodontopathogens. J Microbiol [Internet]. 2016.

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Published

2021-07-07

How to Cite

1.
Nurhayati Abdullah H, Mohamad S, WanTaib WR, Jaffar N. Quorum sensing related activity of Aggregatibacter actinomycetemcomitans in periodontal disease: A review. Biomedicine [Internet]. 2021Jul.7 [cited 2021Jul.24];41(2):174-80. Available from: https://biomedicineonline.org/index.php/home/article/view/778