Quorum sensing related activity of Aggregatibacter actinomycetemcomitans in periodontal disease: A review


  • Haswati Nurhayati Abdullah
  • Suharni Mohamad
  • Wan Rohani WanTaib
  • Norzawani Jaffar




Aggregatibacter actinomycetemcomitans, biofilm, periodontal disease, quorum sensing, auto-inducer


Aggregatibacter actinomycetemcomitans is a significant pathogen in periodontal disease, contributing to aggressive and chronic inflammatory conditions of the periodontal area. This pathogen is shown to contribute to the tenacious biofilm formation in the oral cavity and results in persistent induction of pro-inflammatory response leads to progressive periodontitis. Besides the immune-modulatory capabilities, quorum sensing (QS) activity is believed to influence the virulence activities, leading to a progressive inflammatory response by the host. QS modulates the expression of genes involved in the processes related to survival and biofilm formation activities by answering the localized bacterial population's fluctuation. Understanding the QS activity of this pathogen and its impact on disease might be useful as an alternative approach to counteract the infection. Therefore, this review paper is focusing on the evaluation of the QS activities of A. actinomycetemcomitans and how this activity influences the progression of periodontal disease. Based on the previous findings, we found that there are possibilities the QS activity interrupted by enzymes or molecules that blocking the QS signals produced by other species of bacteria. However, due to minimal QS studies that have been done specifically on A. actinomycetemcomitans, the mechanism is not conclusive. Therefore, this might initiate an essential option for alternative treatment against periodontal pathogen infection and oral health care.

Author Biographies

Haswati Nurhayati Abdullah

  1. Faculty of Health Sciences, Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Terengganu, Terengganu, Malaysia,
  2. School of Dental Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia


Suharni Mohamad

School of Dental Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia

Wan Rohani WanTaib

Faculty of Health Sciences, Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Terengganu, Terengganu, Malaysia

Norzawani Jaffar

School of Dental Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia


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How to Cite

Nurhayati Abdullah H, Mohamad S, WanTaib WR, Jaffar N. Quorum sensing related activity of Aggregatibacter actinomycetemcomitans in periodontal disease: A review. Biomedicine [Internet]. 2021Jul.7 [cited 2021Jul.24];41(2):174-80. Available from: https://biomedicineonline.org/index.php/home/article/view/778