A study of biochemical parameters in pregnant women in III trimester with non-alcoholic fatty liver disease (NAFLD)

Authors

  • Ganesh Pendli
  • G. Chandana
  • Surekha Balaji
  • M. Devi Varaprasad

DOI:

https://doi.org/10.51248/.v41i2.784

Keywords:

NAFLD, dyslipidaemia, cirrhosis, lipid profile

Abstract

Introduction and Aim: Non-alcoholic fatty liver disease (NAFLD) is one of the common causes of liver cirrhosis among general population.Studieshave identified NAFLD and evaluated lipid profile in pregnant women. Some have explored association that existed between lipid levels and adverse pregnancy outcome in western countries. Our aim was to find the prevalence of non-alcoholic fatty liver disease (NAFLD) in pregnant women among rural population in their III trimester and to assess dyslipidemia in these women.

 

Materials and Methods: This is a prospective study conducted on 101 rural pregnant women coming for antenatal visits in their third trimester to Dept.,of Obstetrics and Gynaecology,PESIMSR, Kuppam.Liver scan was done during the regular obstetric scan to identify NAFLD. All pregnant women underwent lipid profile testing (Triglyceride,Total Cholesterol, HDL,LDL,VLDL).

 

Results: There was a 1% prevalence of NAFLD among 101 rural expectant mothers.Lipid profile significantly (p<0.05)increased with increased BMI, parity and highly educated and fairly good socioeconomic background. Women with higher body mass index and triglyceride levels delivered babies with large birth weight(p<0.05).

 

Conclusion: There are metabolic derangements in pregnant women leading to dyslipidemia even among those who did not have NAFLD. High parity women and those with high atherogenicity are at cardiovascular risk diseases in future. We suggest further studies to establish biological reference ranges for lipid profile during pregnancy. There is a need for, pregnant women to be assessed for dyslipidemia and screened for NAFLD by scanning liver along with routine obstetric scan in tertiary care centre.

Author Biographies

Ganesh Pendli

Dept., of Community Medicine, PES Institute of Medical Sciences and Research, Kuppam, 517425, Chittoor, Andhra Pradesh, India

G. Chandana

Dept., of Biochemistry, Kamineni Institute of Medical Sciences,SreepuramNarketpally, 508254, Nalgonda, Telangana, India

Surekha Balaji

Dept., of Radiology, PES Institute of Medical Sciences and Research, Kuppam, 517425, Chittoor, Andhra Pradesh, India

M. Devi Varaprasad

Dept., of Community Medicine, PES Institute of Medical Sciences and Research, Kuppam, 517425, Chittoor, Andhra Pradesh, India

References

Prabhakar,N., Ambali, N.R.,Unnikrishnan, T.K.,Renymol,B.Prevalence of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus and its correlation with coronary artery disease (CAD).International Journal of Research in Medical Sciences. 2017;5(12):5175-5181.

Foghsgaard, Sandreasen,C.,Vedtofte, L.,Anderson,E.S.,Bahne,E.,Strandverg C.,et al.,Non-alcoholic fatty liver disease is prevalent in women with prior gestational diabetes mellitus and independently associated with insulin resistance and waist circumference.Diabetes Care. 2017; 40(1):109-116.

Geraghty, A.A., Alberdi,G.,Sullivan,E.J., McAuliffe, M.F.Maternal and fetal blood lipid concentrations during pregnancy differ by maternal body mass index: finding from ROLO study.BMC pregnancy and childbirth 2017:360

Pusukuru,R., Shenoi,A.S., Kyada,P.K., Ghodke,B., Mehta, V., Bhuta,K., Bhatia, A. Evaluation of Lipid Profile in Second and Third Trimester of Pregnancy. Journal of Clinical and Diagnostic Research. 2016;10(3): QC12-QC16.

Lippi, G., Albiero,A., Montagnana, M.,Salvagno, G.L.,Scevarolli, S., Farnchi, M.,et al.,Lipid and Lipoprotein profile in physiological pregnancy. Clin Lab. 2007;53:173-177.

Jamil,A.A.T., Elsoni, B., Zaki, H.Y., Elbadawi,N.E., Ahmed, E.G., Ibrahim,E.K., et al. Assessment of lipid profile in sudanese pregnant women. Key Research Journal of Biotechnology. 2013;1(1):4-15.

Okojie, F.O., Idonije, O.B., Eseigbe,M.A., Okhiai,O., Unuabonah, F., Dike,M., et al. Comparative study of lipid profile of normal pregnant women in the different trimesters. Archives of Applied Science Research. 2011; 3(3):528-532.

Phuse, S.S., Effective study of lipid profile during pregnancy. International Journal of Applied Biotechnology and Biochemistry. 2012;2(4):381-386.

Hagstrom, H., Hoijer, J.,Ludvigsson, J.F.,Bottai, M.,Ekbom, A., Hultcrantz, R., et al. Adverse outcomes of pregnancy in women with non alcoholic fatty liver disease. Liver International.2016;36(2):268-274.

Souza, L.R.D., Berger, H., Vlachou, H.R.P.V., Maguire, J.L. Non-alcoholic fatty liver disease in early pregnancy predicts dysglycemia in mid-pregnancy: prospective study.The American Journal of Gastroenterology. 2016;111: 665-670.

Castracane,V., Davis, G.,Martinez, B., Maguire,C., Kauffman,R. Non-alcoholic fatty liver disease in pregnant women. Non-alcoholic fatty liver disease in pregnant women. Endocrine Abstracts. 2012; 29:P938

Vrijkotte, T.G.M., Krukziener,N.T., Hutten,C.K.,Eijsden, V.M.V., Twickler, M.B. Maternal Lipid Profile During Early Pregnancy andPregnancy Complications and Outcomes: The ABCD Study. J Clin Endocrinol Metab. November. 2012; 97(11):3917-3925.

Catov, J.M, Ness,R.B., Wellons, M.F., Jacobs,D.R., Roberts, J.M., Gunderson, E.P. Pre-pregnancy lipids related to preterm birth risk: thecoronary artery risk development in young adults study. J Clin EndocrinolMetab. 2010;95:3711-3718.

Jan, M.R., Nazli,R., Shah, J., Akhtar, T.A study of lipoproteins in normal and pregnancy induced hypertensive women in tertiary care hospitals of the North West Frontier Province-Pakistan. Hypertens Pregnancy. 2012; 31:292-299.

Ziaei,S., Bonab,K.M., Kazemnejad, A.Serum lipid levels at 28-32 weeks’ gestation and hypertensive disorders. Hypertens Pregnancy. 2006;25:3-10.

Di Cianni, G., Miccoli,R., Volpe, L., Lencioni, C., Ghio, A., Giovannitti, M.G., et al.,Maternal triglyceride levels and newborn weight inpregnant women with normal glucose tolerance. Diabet Med.2005; 22:21-25.

Edison, R.J., Berg,K., Remaley, A., Kelley,R., Rotimi,C., Stevenson,R.E., et al.,Adverse birth outcome among mothers with lowserum cholesterol. Pediatrics,2007; 120:723-733.

Amundsen, A.L., Khoury, J., Iversen,P.O., Bergei, C., Ose, L., Tonstad,S., et al.,Marked changes in plasma lipids and lipoproteinsduring pregnancy in women with familial hypercholesterolemia.Atherosclerosis.2006;189:451-457.

Hubel, C.A. Dyslipidemia, iron, and oxidative stress in preeclampsia: assessment of maternal and feto-placental interactions. Semin Reprod Endocrinol.1998; 16:75-92.

Kaar, J.L., Crume, T., Brinton, J.T., Bischoff, K.J.,McDuffie, R., Dabelea, D et al.,Maternal obesity, gestational weight gain and offspring adiposity: the EPOCH Study. J Pediatr.2014; 2165(3): 509-515.

Freinkel,N. Effect of the conceptus on maternal metabolism during pregnancy. Excerpta Medica. 1964;12:679-681.

Burtis, C.A. Lipids, lipoproteins, apolipoproteins and other cardiovascular risk factors. Tiez Text book of Clinical Chemistry and molecular diagnostics. 5th edition 731-807.

Anuradha, R., Durga,T. Estimation of lipid profile among preeclampsia woman by comparing with normal pregnancy. International Journal of Contemporary Medical Research.2016;3(7):1958-1961.

Vahratain, A.,Misra, V.K.,Trudeau,S.,Misra, D.P.Pre-pregnancy body mass index and gestational age dependent changes in lipid levels during pregnancy.ObstreticGynecol 2010;116:107-113.

Scifres, C.M.,Catov,J.M.,Simhan,N.H. The impact of maternal obesity and gestational weight gain on early and midpregnacy lipid profile. Obesity. 2014;22:932-938.

Akter, S.,Jesmin,S.,Rahman,M.,Islam, M.M., Kathun, M.T., Yamaguchi, N.,et al., Higher gravidity and parity are associated with increased prevalence of metabolic syndrome among rural Bangladeshi women. PLOS ONE. 2013;8(8) e 68319.

Nigam,P. K. Serum lipid profile: fasting or non-fasting. Indian journal of clinical biochemistry. 2011; 26(1): 96-97.

Magnussen, E.B., Vatten, L.J., Lund-Nilsen, T.I., Salvesen, K.A., Davey Smith,G., Romundstad, P.R. Pre-pregnancy cardiovascular riskfactors as predictors of pre-eclampsia: population-based cohortstudy. BMJ. 2007; 335:978.

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Published

2021-07-07

How to Cite

1.
Pendli G, Chandana G, Balaji S, Devi Varaprasad M. A study of biochemical parameters in pregnant women in III trimester with non-alcoholic fatty liver disease (NAFLD). Biomedicine [Internet]. 2021Jul.7 [cited 2021Jul.24];41(2):199-205. Available from: https://biomedicineonline.org/index.php/home/article/view/784

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Original Research Articles