An updated view: Pathogenicity of Helicobacter pylorimicrobial infection in chronic kidney disease and End stage kidneydysfunction (ESRD) underoxidative stress
Helicobacter pyloriisa Gram-negative, flagellated, microaerophilic bacterium, whichparticularly found inthe human stomach. Pro-as well as anti-inflammatory cytokines along with oxidative stress is acrucial factorin the progressof pepticand gastriculceration as well as gastric carcinoma in subjectshavingchronic H. pylorimicrobial infection.H. pylori eradication from gastrointestinal tract (GIT)is liablefor neuroendocrine modificationbecause ofa stressful feedback of the host and isan indicationfor initiating growth andpathogenic progress in body organs. The importance of H.pylori infectionto renal dysfunctionunderoxidative stress conditionisstill unclear and almost untouched area.In a recent researchstudy, H.pylori infected patients with coexistence ofchronic kidney infectious disease (CKD) and cardiovascular diseases risk factors may beat surpassingrisk of end stage renal disease (ESRD). However, it is hardly known about the fact whether eradication of the bacteria has any consequence on renal function under oxidative stress condition or not. Therefore, the presentstudy anticipatedthisreview along withextra gastric H.pylori infection with progressive development ofchronic kidney diseases and advancement to ESRD,under oxidative stress condition.
Keywords: Extra gastric infection; end stage renal disease; oxidative stress; Helicobacter pylori;genetic mutation;chronic ambulatory peritoneal dialysis
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