HIV Myelopathy- A cross-sectional study of constellation of bone marrow findings in HIV/AIDS

Authors

  • Hemalatha Kuppan Department of Pathology, Apollo Hospital, Chennai, Tamil Nadu, India
  • Vanishri Ashok Hematology Section, Central Laboratory, Kasturba Medical College Hospitals, Ambedkar Circle, Mangalore, Karnataka, India
  • Sridevi Hanaganahalli Basavaiah Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India - 576104
  • Urmila Niranjan Khadilkar Hematology Section, Central Laboratory, Kasturba Medical College Hospitals, Ambedkar Circle, Mangalore, Karnataka, India
  • Nirupama Murali Department of Pathology, Dr. Chandramma Dayananda Sagar Institute of Medical Education and Research, Devarakaggalahalli, Harohalli, Kanakapura Road, Ramanagara Dt., Karnataka - 562 112

DOI:

https://doi.org/10.51248/.v41i4.904

Keywords:

Dysplasia, anemia, HIV, thrombocytopenia, bone marrow

Abstract

Introduction and Aim: Haematological manifestations in HIV disease is common and can happen at any phase during the disease course. Anemia and thrombocytopenia are the most frequent hematologic abnormalities and are associated with high morbidity and mortality. The objective of current study was to observe and analyse various spectrum of bone marrow changes and haematological abnormalities in HIV/AIDS and to correlate findings with CD4 count.

 

Material and Methods: A total of 44 patients over a period of 5 years were included. Clinical findings, hematological profile, bone-marrow aspirate, biopsy findings and CD4 count of these patients were documented. The association between absolute lymphocyte count (ALC) and CD4 count were further established.

 

Results: The most common clinical indication for bone-marrow aspiration and trephine biopsy was pancytopenia (47.3%), pyrexia of unknown origin (15.1%), and unresolving hepatosplenomegaly (13.6%). Anemia (72.7%) was commonest haematological abnormality. Bone marrow aspirate was normocellular in majority of patients. Marrow findings were correlated with CD4 count and were found to be statistically significant. Tri-lineage dysplasia was observed in 9.1% of patients, and megakaryocytic dysplasia being the commonest(61.4%). Histiocytic aggregates (27.3%) were noted among which 6.8% showed acid fast bacilli in Ziehl-Neelsen stain. Fungal stains revealed histoplasmosis in 4.5% patients.

 

Conclusion: There was a strong negative association between presence of anemia and dysplasia and CD4 count. When CD4 was <200/µL and ALC<1000/mm3, presence of anemia and dysplasia affecting various cell lines were commonly observed; therefore, can be used as indicators to assess the severity of the disease.

Author Biography

Vanishri Ashok, Hematology Section, Central Laboratory, Kasturba Medical College Hospitals, Ambedkar Circle, Mangalore, Karnataka, India

Department of Hematology

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Published

2021-12-31

How to Cite

1.
Kuppan H, Ashok V, Hanaganahalli Basavaiah S, Niranjan Khadilkar U, Murali N. HIV Myelopathy- A cross-sectional study of constellation of bone marrow findings in HIV/AIDS. Biomedicine [Internet]. 2021Dec.31 [cited 2022Jan.20];41(4):815-20. Available from: https://biomedicineonline.org/index.php/home/article/view/904

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Original Research Articles