Does serum Vitamin D affect lipid profile?

Authors

  • Monalisa Biswas Department of Biochemistry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India
  • Allabhakshu Shaik Department of Biochemistry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India
  • Krishnananda Prabhu Department of Biochemistry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India

DOI:

https://doi.org/10.51248/.v41i4.908

Keywords:

Atherosclerosis, dyslipidaemia, lipid metabolism, vitamin D, vitamin D deficiency

Abstract

Introduction and Aim: Vitamin D, besides its classical physiological functions, exerts effects on brain, prostate, breast, colon, pancreas, and immune cells due to the ubiquitous presence of its receptors. Hypovitaminosis D predisposes individuals to various micro and macro vascular complications of metabolic syndrome and diabetes mellitus. Despite speculations regarding implications of its deficiency on the cardio metabolic health of general/ susceptible population, its role remains underexplored in the Indian population.

 

Materials and Methods: This cross-sectional study carried out in Biochemistry Department of the institution, recruited 219 patients (after obtaining written consent) of both genders above18 years who underwent Vitamin D testing. Blood samples obtained were assayed for HbA1c, C Reactive protein, thiol and lipid. Kruskal Wallis test and Spearman correlation were employed for statistical analysis.

 

Results: Significantly low HDL and high atherogenic index of plasma (AIP) were observed in males with vitamin D deficiency. Significant inverse correlation of vitamin D with CRP and total cholesterol (among vitamin D deficient males) was observed. A significant inverse correlation between serum HDL and AIP and a significant direct correlation between triglyceride and AIP were observed irrespective of their vitamin D status. Heat map showed marginally elevated lipid parameters among vitamin D insufficient males.

 

Conclusion: Vitamin D may emerge as a surrogate marker in risk stratification of patients with diabetes and dyslipidaemia. More insights are required to assess the gender specific susceptibility to dyslipidaemia and atherosclerosis in relation to vitamin D levels.

References

Wang, Y., Si, S., Liu, J., Wang, Z., Jia, H., Feng, K., et al., The Associations of Serum Lipids with Vitamin D Status. PLoS ONE. 2016; 11(10): e0165157.

Verena Schwetz V, Scharnagl H, Trummer C, Stojakovic T, Pandis M, Grübler M. R., et al., Vitamin D supplementation and lipoprotein metabolism: A randomized controlled trial. Journal of Clinical Lipidology. 2018; 12(3): 588-596.

Gupta, G. R. A. Vitamin D deficiency in India: prevalence, causalities and interventions. Nutrients. 2014; 6(2): 729-775.

Harinarayan, C. V., Holick, M. F., Prasad, U. V., Vani, P. S., Himabindu, G. Vitamin D status and sun exposure in India. Dermatoendocrinol. 2013; 5(1): 130-141.

Aparna, P., Muthathal, S., Nongkynrih, B., Gupta, S. K. Vitamin D deficiency in India. J Family Med Prim Care. 2018; 7(2): 324-330.

Kamboj, P., Dwivedi, S., Toteja, G. S. Prevalence of hypovitaminosis D in India & way forward. Indian J Med Res. 2018; 148: 548-556.

Garg, R., Agarwal, V., Agarwal, P., Singh, S., Malhotra, N. Prevalence of vitamin D deficiency in Indian women. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2018; 7(6): 2222-2225.

Szymczak-Pajor, I., ?liwi?ska, A. Analysis of Association between Vitamin D Deficiency and Insulin Resistance. Nutrients. 2019; 11(4): 794.

Cheng, Q., Boucher, B. J., Leung, P. S. Modulation of hypovitaminosis D-induced islet dysfunction and insulin resistance through direct suppression of the pancreatic islet renin–angiotensin system in mice. Diabetologia. 2013; 56: 553-562.

Sung, C. C., Liao, M. T., Lu, K. C., Wu, C. C. Role of Vitamin D in Insulin Resistance. BioMed Research International. 2012; 2012: 634195.

Infante, M., Ricordi, C., Sanchez, J., Clare-Salzler, M. J., Padilla, N., Fuenmayor, V., et al., Influence of Vitamin D on islet autoimmunity and beta-cell function in type 1 diabetes. Nutrients. 2019; 11(9): 2185.

Sanghera, D. K., Sapkota, B. R., Aston, C. E., Blackett, P. R. Vitamin D status, gender differences, and cardiometabolic health disparities. Ann Nutr Metab. 2017; 70:79-87.

Verdoia, M., Schaffer, A., Barbieri, L., Di Giovine, G., Marino, P., Suryapranata H, De Luca G; Novara Atherosclerosis Study Group (NAS). Impact of gender difference on vitamin D status and its relationship with the extent of coronary artery disease. Nutr Metab Cardiovasc Dis. 2015; 25(5): 464-470.

Jorde, R., Grimnes, G. Vitamin D and Lipids: Do We Really Need More Studies? Circulation. 2012; 126: 252-254.

Challoumas, D. Vitamin D supplementation and lipid profile: What does the best available evidence show? Atherosclerosis. 2014; 235(1): 130-139.

Bhatt, S. P., Misra, A., Gulati, S., Singh, N., Pandey, R. M. Lower vitamin D levels are associated with higher blood glucose levels in Asian Indian women with pre-diabetes: a population-based cross-sectional study in North India. BMJ Open Diabetes Res Care. 2018; 6(1): e000501.

Daga, R. A., Laway, B. A., Shah, Z. A., Mir, S. A., Kotwal, S. K., Zargar, A. H. High prevalence of vitamin D deficiency among newly diagnosed youth-onset diabetes mellitus in north India. Arq Bras Endocrinol Metab. 2012; 56(7): 423-428.

Bayani, M. A., Akbari, R., Banasaz, B., Saeedi, F. Status of Vitamin-D in diabetic patients. Caspian J Intern Med. 2014; 5(1): 40-42.

Karau, P. B., Kirna, B., Amayo, E., Joshi, M., Ngare, S., Muriira, G. The prevalence of vitamin D deficiency among patients with type 2 diabetes seen at a referral hospital in Kenya. Pan Afr Med J. 2019; 34: 38.

Cheng, S., So, W. Y., Zhang, D., Cheng, Q., Boucher, B. J., Leung, P. S. Calcitriol Reduces Hepatic Triglyceride Accumulation and Glucose Output Through Ca2+/CaMKKβ/AMPK Activation Under Insulin-Resistant Conditions in Type 2 Diabetes Mellitus. Curr Mol Med. 2016; 16(8): 747-758.

Dibaba, D. T. Effect of vitamin D supplementation on serum lipid profiles: a systematic review and meta-analysis. Nutrition Reviews. 2019; 77(12): 890-902.

Wang, H., Xia, N., Yang, Y., Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012; 11: 42.

Kim, S. H., Baek, M. S., Yoon, D. S., Park, J. S., Yoon, B. W., Oh, B. S., et al., Vitamin D inhibits expression and activity of matrix metalloproteinase in human lung fibroblasts (HFL-1) cells. Tuberc Respir Dis (Seoul). 2014; 77(2): 73-80.

Pike, J. W., Christakos, S. Biology and Mechanisms of Action of the Vitamin D Hormone. Endocrinol Metab Clin North Am. 2017; 46(4): 815-843.

Umar, M., Sastry, K. S., Chouchane, A. I. Role of Vitamin D beyond the skeletal function: a review of the molecular and clinical studies. Int J Mol Sci. 2018; 19(6): 1618.

Almeida, L. F., Coimbra, T. M. Vitamin D actions on cell differentiation, proliferation and inflammation. Int J Complement Alt Med. 2017; 6(5): 00201.

Bikle, D. Vitamin D: Production, metabolism, and mechanisms of action. [Updated 2017 Aug 11]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet].

Mozos, I., Marginean, O. Links between Vitamin D deficiency and cardiovascular diseases. Biomed Res Int. 2015; 2015: 109275.

Kim, M. R., Jeong, S. J. Relationship between Vitamin D Level and Lipid Profile in Non-Obese Children. Metabolites. 2019; 9(7): 125.

Chaudhuri, J. R., Mridula, K. R., Anamika, A., Boddu, D. B., Misra, P. K., Lingaiah, A., et al., Deficiency of 25-Hydroxyvitamin D and Dyslipidemia in Indian Subjects. Journal of Lipids. 2013; 2013: 623420.

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Published

2021-12-31

How to Cite

1.
Biswas M, Shaik A, Prabhu K. Does serum Vitamin D affect lipid profile?. Biomedicine [Internet]. 2021Dec.31 [cited 2022Jan.20];41(4):787-92. Available from: https://biomedicineonline.org/index.php/home/article/view/908

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Original Research Articles