Association of osteoprotegerin and lipid risk factors with severity of stenosis in coronary artery disease patients with diabetes mellitus

Abstract

Introduction and Aim: Type-2 diabetes mellitus (T2DM) is a major risk factor for coronary artery diease (CAD). CAD patients with severe stenosis undergo angiography as a part of diagnostic and interventional cardiac care. Gensini scoring system can quantify stenosis which is done during angiogam, an invasive procedure associated with substantial risk. Osteoprotegerin is a protein involved in calcification. Therefore, India being the diabetic capital of world, in the pressent study, we explored the link of osteoprotegerin (OPG) with the severity of stenosis in CAD patients with history of T2DM.

Materials and Methods: We assessed serum OPG, fasting blood sugar, calcium, lipid profile and lipid risk factors in CAD patients with history of T2DM (n=109) and gensisni score was assigned from angiogram. We analyzed the correlation of biochemical parameters with Gensisni score, the gold standard for the assessment of stenosis severity.

Results: Gensisni score was significantly correlated to the type of vessel disease (p<0.000) while osteoprotegerin was positively linked (p<0.05) in CAD patients with diabetes. Among the lipid risk factors, TG/HDL-C and atherogenic index of plasma (AIP) were positively linked to Gensisni score.

Conclusion: Serum level of osteoprotegerin and lipd risk factors correlate with severity of stenosis. Therefore, osteoprotegerin can be used as a novel screening tool in the Indian population, for CAD patients with a history of
diabetes, as an indicator for undergoing angiogram.

Keywords: Coronary artery disease; type-2 diabetes mellitus; osteoprotegerin; stenosis