TY - JOUR AU - Biswas, Monalisa AU - Shaik , Allabhakshu AU - Prabhu, Krishnananda PY - 2021/12/31 Y2 - 2024/03/28 TI - Does serum Vitamin D affect lipid profile? JF - Biomedicine JA - Biomedicine VL - 41 IS - 4 SE - Original Research Articles DO - 10.51248/.v41i4.908 UR - https://biomedicineonline.org/index.php/home/article/view/908 SP - 787-792 AB - <p><strong>Introduction and Aim: </strong>Vitamin D, besides its classical physiological functions, exerts effects on brain, prostate, breast, colon, pancreas, and immune cells due to the ubiquitous presence of its receptors. Hypovitaminosis D predisposes individuals to various micro and macro vascular complications of metabolic syndrome and diabetes mellitus. Despite speculations regarding implications of its deficiency on the cardio metabolic health of general/ susceptible population, its role remains underexplored in the Indian population.</p><p> </p><p><strong>Materials and Methods: </strong>This cross-sectional study carried out in Biochemistry Department of the institution, recruited 219 patients (after obtaining written consent) of both genders above18 years who underwent Vitamin D testing. Blood samples obtained were assayed for HbA1c, C Reactive protein, thiol and lipid. Kruskal Wallis test and Spearman correlation were employed for statistical analysis.</p><p> </p><p><strong>Results: </strong>Significantly low HDL and high atherogenic index of plasma (AIP) were observed in males with vitamin D deficiency. Significant inverse correlation of vitamin D with CRP and total cholesterol (among vitamin D deficient males) was observed. A significant inverse correlation between serum HDL and AIP and a significant direct correlation between triglyceride and AIP were observed irrespective of their vitamin D status. Heat map showed marginally elevated lipid parameters among vitamin D insufficient males.</p><p> </p><p><strong>Conclusion: </strong>Vitamin D may emerge as a surrogate marker in risk stratification of patients with diabetes and dyslipidaemia. More insights are required to assess the gender specific susceptibility to dyslipidaemia and atherosclerosis in relation to vitamin D levels.</p> ER -