Biomedicine 2021-07-24T01:04:33+08:00 Prof.Manjula Shantaram Open Journal Systems <p>Biomedicine (Print ISSN: 0970 2067), official publication of Indian Association of Biomedical Scientists (IABMS), published quarterly in March, June, September and December. It is an International Journal for Biomedical Sciences. The journal publishes research papers, reviews, special article, case report, book review and letter to the editor related to Anatomy, Physiology, Biochemistry, Microbiology, Toxicology, Endocrinology, Reproductive Biology, Pharmacology and Alternative Systems of Medicines like Siddha, Unani, Ayurveda, Homeopathy and Naturopathy. Preference will be given to papers of immediate importance to other investigators, either by their experimental data, new ideas or new methodology. Scientific correspondence to the Editor-in-Chief related to the published papers may also be accepted provided that they are short and scientifically relevant to the papers mentioned, in order to provide a continuing forum for discussion.</p> <p><strong>Abstracting and Indexing</strong></p> <p>It is indexed in Excerpta Medica, Scopus, Google Scholar, Elsevier Indian Citation Index, Index Medicus, and UGC- CARE. NLM Unique ID: 8405231. Meta Data deposited in DOI and citation is tracked by crossref.</p> Impact of COVID-19 Related Stress on Glycaemic Control in Patients with Type 2 Diabetes Mellitus 2021-07-24T01:04:33+08:00 Rohini Patil Kamal Shah Deepak Bhosle <p><strong>Objective:</strong>&nbsp; To evaluate the impact of stress on glycaemic control in types 2 diabetes patients hospitalized for the treatment of coronavirus disease (COVID-19).</p> <p><strong>Material and Methods</strong>: In this retrospective study, hospitalized COVID-19 patients with type 2 diabetes who reported having stress of pandemic were included with purposive sampling. DASS-12 stress sub-scale was used to estimate severity of stress. Fasting blood glucose (FBG) and post-prandial blood glucose (PPBG) before admission and at the time of discharge was compared.</p> <p>&nbsp;<strong>Results:</strong> A total of 199 patients (mean age 54 year; 61.30% females) were included. Mean (SD) FBG before admission 168.4 (30.6) mg/dl increased to 195.9 (28.8) mg/dl at the time of discharge (p&lt;0.001). Mean (SD) PPBG before admission 312 (62.3) mg/dl increased to 351.6 (61.9) mg/dl (p&lt;0.001).&nbsp; A total of 73 (36.7%) had perceived stress. Moderate and severe/extremely severe stress was found in 44 (27.1%) and 19 (9.6%) patients respectively. There was significant difference in mean FBG before and at the time of discharge in patients with no stress and those with moderate stress (p&lt;0.001). However, there was no significant difference in mean FBG in patients with severe/extremely severe stress (p=043). Similar observations were seen for PPBG (no stress p&lt;0.001; moderate stress p&lt;0.001; severe/extremely severe stress p=0.06).</p> <p><strong>Conclusion:</strong> There was rise in glucose level in type-2 diabetes patients discharged after COVID-19 treatment. The rise was significant in type-2 diabetes without stress and those with moderate stress. In addition to traditional treatment, measures for psychological stress control should also be considered in such patients.</p> Copyright (c) Novel Urinary markers: taurine, dopamine and L-fucose levels in predicting neonatal seizures 2021-07-23T18:48:18+08:00 Vijetha Shenoy Varashree BS Sravya Poduri Leslie Edward Lewis <p><strong>Novel Urinary markers: taurine, dopamine and L-fucose levels in predicting neonatal seizures</strong></p> <p><strong>Background:</strong></p> <p>Neonatal seizure is an age specific neurological emergency. Their unique pathophysiological mechanism has become subject of interest for many research studies. The recurrence risk for seizures is high during neonatal period and currently used treatment strategies have limited efficacy in preventing it. From past decades although the treatment has not changed, there is a gradual progress in various mechanisms that are involved in generation of seizures and their response to anti epileptics. With the emergence of new biochemical parameters for risk assessment in patients with seizures, there is a strong need for their comparative evaluation in order to evaluate their potential clinical application. So, this study was carried out to compare the urine levels of taurine, dopamine and fucose in assessing their role in mechanism of seizure.</p> <p>&nbsp;</p> <p><strong>Materials and Methods:</strong></p> <p>After obtaining ethical approval and consent from parents total 43 neonates, urine taurine, dopamine and fucose were measured in 24 cases of seizures and 19 apparently healthy normal controls. Dopamine and Taurine were measured using ELISA and L-fucose by Dische and Shettles method.</p> <p>&nbsp;</p> <p><strong>Results:</strong></p> <p>The median level of urine fucose was significantly higher in male cases, taurine was significantly decreased in cases compared to that of controls. Males had higher preponderance to develop seizures. The median levels of urine dopamine were high in cases compared to controls but has not showed any significance.</p> <p>&nbsp;</p> <p><strong>Conclusion:</strong></p> <p>Amino acid like taurine, carbohydrate moiety like fucose and a neuromodulator like dopamine may have a mechanistic role in development of seizures in neonatal period.</p> <p>&nbsp;</p> <p>&nbsp;</p> <p>&nbsp;</p> <p><strong>&nbsp;</strong></p> Copyright (c) BARRIERS RELATED TO SELF-CARE MANAGEMENT AMONG PEOPLE WITH DIABETES MELLITUS- A NARRATIVE REVIEW 2021-07-23T15:26:51+08:00 Mamta Nebhinani Rishi Dutt Avasthi Meenakshi Meena Megha Parihar Megha Sharma Monika Nagar Neha Nisha <p>Diabetes is a challenging disease that is considered to be hard to live with as it encompasses a lot of restrictions, lifestyle and behavioural modifications. Diabetes self-care management behaviors are essential to obtain glycaemic control and lessen the risk of complications. Although an import aspect leading to positive health outcomes among diabetic patients, diabetes self-care management is usually is a complex process.&nbsp; This narrative review summates barriers related to self-care management among people diabetes people. The literature was searched through PubMed and google scholar databases using various keywords and MeSH terminologies. Furthermore, selected articles reference list was also screened. It is concluded that self-care management in diabetes mellitus is often surrounded by many barriers. Deficiency of environmental resources and assisted strategies, poor awareness regarding self-care skills, lack of motivation and financial constraints are the major barriers faced by people with diabetes mellitus. Endeavour to withdraw barriers are prime in aiding people with diabetes to improve their quality of life and to attain positive health outcomes.</p> <p><em><strong>&nbsp;</strong></em></p> <p><strong>&nbsp;</strong></p> Copyright (c) -Effect of Cardiopulmonary Resucitation (CPR) Training and AED training among medical interns in a private medical college . 2021-07-23T14:25:09+08:00 dr archana bhat <p>ABSTRACT</p> <p>Introduction :Knowledge about basic life support (BLS) is mandatory for health care professionals.This study is done with the objective to evaluate the knowledge about cardiopulmonary resucication(CPR) and use of automated external defibrillators (AED) among medical students who have completed MBBS course and have enrolled for internship.</p> <p>&nbsp;</p> <p>Materials and methods: A cross sectional study using a validated questionnaire was given to MBBS interns&nbsp; before BLS training and &nbsp;same questionnaire was given one month after the training.The questionnaire included knowledge and&nbsp; attitudes towards use of CPR and AED and management of choking .</p> <p>&nbsp;</p> <p>Results:</p> <p>Out of the 86 students who answered the&nbsp; questionnaire the mean score was 11.28 &nbsp;during the pretest..In the post test questionnaire the mean score was 13.91 .There was a statistically significant difference (p=0.000) in the post test scores conducted after one month.39.6% students scored average marks (5-10 ) in the pretest and 60.4% students scored good&nbsp; (10-15) marks in the pretest . After the training session in the post test&nbsp; 97.7% students scored good marks (10-15) while only 2.32% scored average marks .The p value &lt;0.001,chisquare =35.97 is highly significant.</p> <p>&nbsp;</p> <p>Conclusion :BLS training helps to increase knowledge of CPR and the use of an AED.</p> <p>&nbsp;</p> <p>Keywords</p> <p>Knowledge , questionnaire , basic life support&nbsp; study</p> <p>&nbsp;</p> <p>&nbsp;</p> <p>&nbsp;</p> Copyright (c) Effect of Metformin therapy on lipid profile in obese and non-obese women with Polycystic Ovarian Syndrome (PCOS). 2021-07-22T17:33:07+08:00 a swathi Reddy Vijayalakshmi Yogananda Reddy <p><strong>ABSTRACT</strong></p> <p><strong>Introduction &amp; Aim: </strong>Polycystic ovarian syndrome is the most common endocrine disorder affecting the reproductive system in women. It is characterized by obesity, irregular menstruation, anovulation, hirsutism, insulin resistance, and dyslipidemia. Metformin, an oral anti-diabetic drug is known to stabilize metabolic disturbances caused by PCOS. This study aims to determine the effect of metformin therapy on lipid profile in obese and non-obese women with the polycystic ovarian syndrome.</p> <p><strong>Materials and methods: </strong>It is a prospective, clinical, interventional study, participated by 60 women aged between 13 to 45 years, suffering from PCOS, who are attending the gynecology outpatient department at SVS medical college and hospital, for 1 year. By following inclusion and exclusion criteria, based on the Body Mass Index, the subjects were divided into two groups, Group-1 (Obese women) and Group-2 (non-obese women), and received Metformin orally with doses of 500mg/day for a year. The present study was approved by the Institutional Ethical committee. Demographic parameters age, BMI, and lipid profile including High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL), Triglycerides (TAG), and Total Cholesterol (TC) were estimated. Statistical analysis was done by using SPSS software and p&lt;0.001 was considered statistically significant.</p> <p><strong>Results: </strong>A combined group study of obese and non-obese women subjects showed a BMI decrease in non-obese subjects at 6 months by Metformin therapy. HDL levels increased in non-obese women subjects with a statistical significance. LDL and TAG levels remained unchanged at 6 months by Metformin therapy in both groups. Total cholesterol levels were high in non-obese women and remained unchanged in the obese women group showing a statistical significance after Metformin treatment.</p> <p><strong>Conclusion: </strong>Metformin has an optimistic and beneficial effect on the lipid profile and BMI of women suffering from PCOS, hence can help control metabolic disturbances.</p> <p><strong>Keywords: </strong>Metformin; Polycystic ovarian syndrome; lipid profile; obese and non-obese women</p> Copyright (c)