Biomedicine https://biomedicineonline.org/index.php/home <p>Biomedicine (Print ISSN: 0970 2067), official publication of Indian Association of Biomedical Scientists (IABMS), published quarterly in March, June, September and December. It is an International Journal for Biomedical Sciences. The journal publishes research papers, reviews, special article, case report, book review and letter to the editor related to Anatomy, Physiology, Biochemistry, Microbiology, Toxicology, Endocrinology, Reproductive Biology, Pharmacology and Alternative Systems of Medicines like Siddha, Unani, Ayurveda, Homeopathy and Naturopathy. Preference will be given to papers of immediate importance to other investigators, either by their experimental data, new ideas or new methodology. Scientific correspondence to the Editor-in-Chief related to the published papers may also be accepted provided that they are short and scientifically relevant to the papers mentioned, in order to provide a continuing forum for discussion.</p> <p> </p> <p><strong>Abstracting and Indexing</strong></p> <p>Abstract and Articles are indexed in various databases, such as,</p> <p><a href="https://www.scopus.com/sourceid/28618#tabs=2"><strong>Scopus</strong></a></p> <p><strong>Excerpta Medica</strong></p> <p><strong>Google Scholar</strong></p> <p><strong>Elsevier Indian Citation Index</strong></p> <p><strong>Index Medicus,</strong></p> <p><strong>UGC- CARE</strong></p> <p><strong>NLM Unique ID: 8405231</strong>.</p> <p>Meta Data deposited in DOI and citation is tracked by<strong> crossref.</strong></p> Indian Association of Biomedical Scientists (IABMS) en-US Biomedicine 0970-2067 Coconut (Cocos nucifera L.) inflorescence sap-derived sugar restores the glucose and lipid homeostasis in streptozotocin-induced diabetic Wistar rat model https://biomedicineonline.org/index.php/home/article/view/1453 <p>Coconut palm sugar (CPS) is a promising functional food comprising unique phyto-nutrients such as polyphenolics, minerals, inulin etc. and low GI property. Based on its distinctive biochemical composition it was hypothesized that CPS would provide glucose homeostatic effect. We investigated the effects of oral administration of CPS in a streptozotocin-induced diabetic Wistar rat model.&nbsp; Diabetic Wistar rats were treated with CPS200, CPS400 and CPS800 representing 200,400 and 800mg/Kg body weight (b.w) of CPS, respectively along with the standard drug gliclazide (5mg/Kg b.w) during a period of 28 days. Biochemical features underlying glucose, lipid balance and pancreatic anti-oxidant status of all the animal groups were monitored. Administration of CPS to diabetic rats reduced the body weight loss, and fasting blood glucose levels in a dose-dependent manner. CPS treatment showed a highly significant (<em>P</em>?0.001) reduction in plasma glucose levels 120 min after glucose load, reduction in serum blood glucose, hepatic enzymes <em>viz</em>., aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (AP); serum lipid profile of total triglycerides, total cholesterol, low density lipoprotein fraction. However, it significantly increased the serum total protein and high density lipoprotein. CPS restored the levels of pancreatic enzymatic antioxidants and decreased lipid peroxidation. CPS exhibited multiple health benefits in diabetic rats by restoring the glucose and lipid homeostasis and accords beneficial effects against oxidative stress. CPS could be a promising food for diabetics.</p> Shilpa Shetty Ramesh SV Arivalagan Roopashree PG Manikantan MR Hebbar KB Suchetha Kumari Copyright (c) 41 4 The Therapeutic Implications of an Isoquinolone Alkaloid Berberine in the Gastrointestinal Tract https://biomedicineonline.org/index.php/home/article/view/1452 <p><strong>Background</strong><strong>: </strong>Berberine is a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids. It is found in such plants as Berberis (<em>Berberis aquifolium</em>,<em> Berberis vulgaris</em>,<em> Berberis aristata</em>,<em> Hydrastis canadensi</em>s,<em> Phellodendron amurense</em>,<em> Tinospora cordifolia</em>,<em> Argemone Mexicana</em>). Preliminary clinical evidence suggests the ability of berberine to reduce endothelial inflammation improving vascular health, even in patients already affected by cardiovascular diseases. <strong>Objective: </strong>This paper presents the therapeutic action of berberine in the treatment of Inflammatory Bowel Diseases (IBD). <strong>Materials &amp; Methods</strong>: Berberine was isolated from the dried stem bark extract of <em>Berberis aristata</em> DC. for its screening in TNBS induced colitis model using albino wistar rats experimentally. <strong>Conclusion:</strong> Therapeutic effect of berberine showed significant reduction of colitic symptoms in the treated rats, Hence it is useful in future clinical treatment of anti inflammatory bowel diseases, which was critically analyzed and presented in detail in this paper first time.</p> Saumya Das Manas Kumar Das Copyright (c) 41 4 Effectiveness of PNF stretch of pectoralis major muscle on pulmonary function in COPD patients https://biomedicineonline.org/index.php/home/article/view/1450 <p><strong>ABSTRACT</strong>: COPD is a common and a progressive disorder that is characterised by respiratory symptoms and airflow limitation due to the abnormalities of the airway or alveoli. Proprioceptive neuromuscular facilitation technique can increase the contractive capacity of muscles. The study aimed at assessing the effect of Proprioceptive neuromuscular facilitation stretch of pectoralis major muscle on chest expansion and pulmonary function values in COPD patients.</p> <p>Methods: hold relax PNF of pectoralis major muscle was given for a duration of 6 weeks on the particpants who are met with inclusion and exclusion criteria. Chest expansion was measured at axillary level and xiphisternal level , FEV1,FVC and FEV1/FVC were measured pre and the post intervention.</p> <p>Results: statistical analysis was done using paired t test (p&lt;0.05). the results of&nbsp; the study shows that there is increase in the chest expansion at axillary level and xiphisternal level and increase in the FEV1/FVC&nbsp; ratio following 6 weeks of hold relax PNF stretch of pectoralis&nbsp; major in COPD patients.</p> <p>Conclusion: the study concludes that with hold relax PNF stretch there is increase in chest expansion and pulmonary function values. The results also provide evidence that hold relax PNF of pectoralis major can be added in the pulmonary rehabilitation of COPD patients.</p> Siva Jyothi Neerukonda Senthil Selvam P Md. Ahmedullah Yatheendra Kumar.G Subramanian SS Jibi Paul Copyright (c) 41 4 Diagnostic performance of waist-hip ratio as a screening tool in identifying obesity in school children as compared to body mass index. https://biomedicineonline.org/index.php/home/article/view/1444 <p><strong>Background:</strong></p> <p>&nbsp; &nbsp;Increasing prevalence of obesity in children, in recent years, has demanded newer ways for early identification. Various anthropometric methods are being used to detect obesity in children. This study aimed to analyze whether waist-to-hip ratio (WHR) can be used detect obesity as compared to body mass index (BMI), and to derive optimal cutoffs for WHR, in young children.</p> <p><strong>Methods:</strong></p> <p>&nbsp;&nbsp; This cross-sectional study was conducted in a total sample of 1020 children aged 6-12 years, from four schools in Puducherry, over one year. The children were subjected to anthropometric measurements and obesity was defined as per revised Indian Academy of Pediatrics (IAP) 2015 recommendations on BMI percentiles chart. Receiver operating characteristic (ROC) analysis was employed to assess the diagnostic accuracy of WHR for elevated BMI and to derive WHR cutoffs in this age group.</p> <p><strong>Results: </strong></p> <p>&nbsp;In this study, the prevalence of obesity was 15.2% and overweight was 14.5%. WHR showed significant correlation with elevated BMI, with the area under the curve for the entire study population being 0.96 (95% CI = 0.95-0.97, p-value = &lt;0.001). The optimal cut-off of WHR for the age group of 6-12 years was derived as 0.79, with sensitivity and specificity of 100% and 91.5%, respectively. The optimal WHR cut-off for males and females, with the highest sensitivity and specificity, was arrived at 0.79 and 0.75, respectively.</p> <p><strong>Conclusion: </strong></p> <p>WHR can be used as a simple, inexpensive, and accurate tool for obesity screening in school-going children.</p> Vikneswari Karthiga S Amrutha Venkateswaran Anandhi Chandramohan Soundararajan Palanisamy Copyright (c) 41 4 Circulating pre-B-cell colony – enhancing factor (PBEF) / Visfatin and cardio metabolic risk in young obese adults. https://biomedicineonline.org/index.php/home/article/view/1451 <p>In this era of obesity pandemic, obesity related metabolic dearrangements has demanded more clinical attention due to its high rate of morbidity and mortality. Altered lipid profile and atherogenicity have increased the cardio metabolic risks, even in young adults and adolescents. Among various adipocytokines, PBEF/visfatin, predominantly secreted from the visceral fat, helps to predict the amount of visceral fat which is strongly associated with the altered metabolic risk profile than the subcutaneous fat. This study aims to evaluate serum visfatin levels, and to find the association between serum visfatin levels and lipid parameters, atherogenic index and body fat distribution, in young obese adults. We measured serum visfatin in 60 obese adults (19 – 35 yrs) and 30 age and sex matched non-obese controls. . Anthropometric indices, Body mass index (BMI), waist circumference (WC ),waist–hip ratio (WHR) and lipid parameters such as Triglycerides (TG),Low-Density Lipoprotein (LDL-C), High-Density Lipoprotein (HDL-C) were measured and atherogenic index (log TG/ HDL-C) &nbsp;was calculated. Serum Visfatin levels was significantly higher in obese than the control group (P&lt; 0.00). The obese study group had significantly higher BMI, WC, WHR, TG, LDL - C with P value &lt; 0.05. The atherogenic index was also significantly higher in cases than controls (P &lt; 0.016). Among the obese group, serum visfatin levels was positively correlated with &nbsp;TG (r : 0.32 P:0.04), LDL-C(r : 0.911 P:0.00) and atherogenic index(r : 0.599 P:0.00). There was also positive correlation between BMI and atherogenic index (r : 0.568 P:0.01). This study highlights that serum visfatin, due to its association with the atherogenic index, proves to be an important marker for assessing the metabolic risks of an obese individual. The higher atherogenic index in obese subjects reveals the impact of visceral fat in the initiation of atherosclerosis even in young adults.</p> Anitha G. Sivakumar J Rasheed khan M Copyright (c) 41 4