Biomedicine https://biomedicineonline.org/index.php/home <p>Biomedicine (Print ISSN: 0970 2067), official publication of Indian Association of Biomedical Scientists (IABMS), published quarterly in March, June, September and December. It is an International Journal for Biomedical Sciences. The journal publishes research papers, reviews, special article, case report, book review and letter to the editor related to Anatomy, Physiology, Biochemistry, Microbiology, Toxicology, Endocrinology, Reproductive Biology, Pharmacology and Alternative Systems of Medicines like Siddha, Unani, Ayurveda, Homeopathy and Naturopathy. Preference will be given to papers of immediate importance to other investigators, either by their experimental data, new ideas or new methodology. Scientific correspondence to the Editor-in-Chief related to the published papers may also be accepted provided that they are short and scientifically relevant to the papers mentioned, in order to provide a continuing forum for discussion.</p> <p> </p> <p><strong>Abstracting and Indexing</strong></p> <p>Abstract and Articles are indexed in various databases, such as,</p> <p><a href="https://www.scopus.com/sourceid/28618#tabs=2"><strong>Scopus</strong></a></p> <p><strong>Excerpta Medica</strong></p> <p><strong>Google Scholar</strong></p> <p><strong>Elsevier Indian Citation Index</strong></p> <p><strong>Index Medicus,</strong></p> <p><strong>UGC- CARE</strong></p> <p><strong>NLM Unique ID: 8405231</strong>.</p> <p>Meta Data deposited in DOI and citation is tracked by<strong> crossref.</strong></p> en-US editor-in-chief@biomedicineonline.org (Prof.Manjula Shantaram) support@biomedicineonline.org (Journal Manager) Fri, 31 Dec 2021 13:57:05 +0800 OJS 3.2.1.1 http://blogs.law.harvard.edu/tech/rss 60 AYURVEDIC MANAGEMENT GOUT AND HYPERURICEMIA: A CASE REPORT https://biomedicineonline.org/index.php/home/article/view/1454 <p><strong>Abstract:</strong> Gout is a&nbsp;conjoint and multifaceted form of arthritis&nbsp;that can disturb anyone. In Ayurerda address as <em>Vatarakta</em>. Gout is a kind of arthritis affected by a accumulation of uric acid crystals in the joints. Hyperuricemia (increase uric acid level) are a common illness that affects patients of all ages and sexes. Uric acid is the final oxidation product of purine metabolism and in humans the most common manifestation of hyperuricemia is gout, which can be very painful and is difficult to treat. Gout is the commonest form of crystal induced arthritis having disturbed acid metabolism, precipitation of urate crystals in extracellular space of joints, periarticular tissue, bones and other organs. It&nbsp;is a&nbsp;systemic disease characterized by manifestations of chronic underlying hyperuricemia,&nbsp;leading to&nbsp;the deposition of monosodium urate crystals in various tissues. In this clinical report, it was found that Ayurvedic intervention has reduced pain, Tenderness, Oedema and Erythema. Also uric acid, which was 11.99 mg / dl, came to 5 mg / dl after treatment.</p> Jeuti Rani Das, Pravin Masram, Praveen Kumar, Ekta Copyright (c) https://biomedicineonline.org/index.php/home/article/view/1454 Coconut (Cocos nucifera L.) inflorescence sap-derived sugar restores the glucose and lipid homeostasis in streptozotocin-induced diabetic Wistar rat model https://biomedicineonline.org/index.php/home/article/view/1453 <p>Coconut palm sugar (CPS) is a promising functional food comprising unique phyto-nutrients such as polyphenolics, minerals, inulin etc. and low GI property. Based on its distinctive biochemical composition it was hypothesized that CPS would provide glucose homeostatic effect. We investigated the effects of oral administration of CPS in a streptozotocin-induced diabetic Wistar rat model.&nbsp; Diabetic Wistar rats were treated with CPS200, CPS400 and CPS800 representing 200,400 and 800mg/Kg body weight (b.w) of CPS, respectively along with the standard drug gliclazide (5mg/Kg b.w) during a period of 28 days. Biochemical features underlying glucose, lipid balance and pancreatic anti-oxidant status of all the animal groups were monitored. Administration of CPS to diabetic rats reduced the body weight loss, and fasting blood glucose levels in a dose-dependent manner. CPS treatment showed a highly significant (<em>P</em>?0.001) reduction in plasma glucose levels 120 min after glucose load, reduction in serum blood glucose, hepatic enzymes <em>viz</em>., aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (AP); serum lipid profile of total triglycerides, total cholesterol, low density lipoprotein fraction. However, it significantly increased the serum total protein and high density lipoprotein. CPS restored the levels of pancreatic enzymatic antioxidants and decreased lipid peroxidation. CPS exhibited multiple health benefits in diabetic rats by restoring the glucose and lipid homeostasis and accords beneficial effects against oxidative stress. CPS could be a promising food for diabetics.</p> Shilpa Shetty, Ramesh SV, Arivalagan, Roopashree PG, Manikantan MR, Hebbar KB, Suchetha Kumari Copyright (c) https://biomedicineonline.org/index.php/home/article/view/1453 The Therapeutic Implications of an Isoquinolone Alkaloid Berberine in the Gastrointestinal Tract https://biomedicineonline.org/index.php/home/article/view/1452 <p><strong>Background</strong><strong>: </strong>Berberine is a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids. It is found in such plants as Berberis (<em>Berberis aquifolium</em>,<em> Berberis vulgaris</em>,<em> Berberis aristata</em>,<em> Hydrastis canadensi</em>s,<em> Phellodendron amurense</em>,<em> Tinospora cordifolia</em>,<em> Argemone Mexicana</em>). Preliminary clinical evidence suggests the ability of berberine to reduce endothelial inflammation improving vascular health, even in patients already affected by cardiovascular diseases. <strong>Objective: </strong>This paper presents the therapeutic action of berberine in the treatment of Inflammatory Bowel Diseases (IBD). <strong>Materials &amp; Methods</strong>: Berberine was isolated from the dried stem bark extract of <em>Berberis aristata</em> DC. for its screening in TNBS induced colitis model using albino wistar rats experimentally. <strong>Conclusion:</strong> Therapeutic effect of berberine showed significant reduction of colitic symptoms in the treated rats, Hence it is useful in future clinical treatment of anti inflammatory bowel diseases, which was critically analyzed and presented in detail in this paper first time.</p> Saumya Das; Dr. Copyright (c) https://biomedicineonline.org/index.php/home/article/view/1452 Effectiveness of PNF stretch of pectoralis major muscle on pulmonary function in COPD patients https://biomedicineonline.org/index.php/home/article/view/1450 <p><strong>ABSTRACT</strong>: COPD is a common and a progressive disorder that is characterised by respiratory symptoms and airflow limitation due to the abnormalities of the airway or alveoli. Proprioceptive neuromuscular facilitation technique can increase the contractive capacity of muscles. The study aimed at assessing the effect of Proprioceptive neuromuscular facilitation stretch of pectoralis major muscle on chest expansion and pulmonary function values in COPD patients.</p> <p>Methods: hold relax PNF of pectoralis major muscle was given for a duration of 6 weeks on the particpants who are met with inclusion and exclusion criteria. Chest expansion was measured at axillary level and xiphisternal level , FEV1,FVC and FEV1/FVC were measured pre and the post intervention.</p> <p>Results: statistical analysis was done using paired t test (p&lt;0.05). the results of&nbsp; the study shows that there is increase in the chest expansion at axillary level and xiphisternal level and increase in the FEV1/FVC&nbsp; ratio following 6 weeks of hold relax PNF stretch of pectoralis&nbsp; major in COPD patients.</p> <p>Conclusion: the study concludes that with hold relax PNF stretch there is increase in chest expansion and pulmonary function values. The results also provide evidence that hold relax PNF of pectoralis major can be added in the pulmonary rehabilitation of COPD patients.</p> Siva Jyothi Neerukonda, Dr, Mr, Dr, Dr, Dr Copyright (c) https://biomedicineonline.org/index.php/home/article/view/1450 Diagnostic performance of waist-hip ratio as a screening tool in identifying obesity in school children as compared to body mass index. https://biomedicineonline.org/index.php/home/article/view/1444 <p><strong>Background:</strong></p> <p>&nbsp; &nbsp;Increasing prevalence of obesity in children, in recent years, has demanded newer ways for early identification. Various anthropometric methods are being used to detect obesity in children. This study aimed to analyze whether waist-to-hip ratio (WHR) can be used detect obesity as compared to body mass index (BMI), and to derive optimal cutoffs for WHR, in young children.</p> <p><strong>Methods:</strong></p> <p>&nbsp;&nbsp; This cross-sectional study was conducted in a total sample of 1020 children aged 6-12 years, from four schools in Puducherry, over one year. The children were subjected to anthropometric measurements and obesity was defined as per revised Indian Academy of Pediatrics (IAP) 2015 recommendations on BMI percentiles chart. Receiver operating characteristic (ROC) analysis was employed to assess the diagnostic accuracy of WHR for elevated BMI and to derive WHR cutoffs in this age group.</p> <p><strong>Results: </strong></p> <p>&nbsp;In this study, the prevalence of obesity was 15.2% and overweight was 14.5%. WHR showed significant correlation with elevated BMI, with the area under the curve for the entire study population being 0.96 (95% CI = 0.95-0.97, p-value = &lt;0.001). The optimal cut-off of WHR for the age group of 6-12 years was derived as 0.79, with sensitivity and specificity of 100% and 91.5%, respectively. The optimal WHR cut-off for males and females, with the highest sensitivity and specificity, was arrived at 0.79 and 0.75, respectively.</p> <p><strong>Conclusion: </strong></p> <p>WHR can be used as a simple, inexpensive, and accurate tool for obesity screening in school-going children.</p> Vikneswari Karthiga S, Amrutha Venkateswaran, Anandhi Chandramohan, Soundararajan Palanisamy Copyright (c) https://biomedicineonline.org/index.php/home/article/view/1444