Biomedicine <p>Biomedicine (Print ISSN: 0970 2067), official publication of Indian Association of Biomedical Scientists (IABMS), published quarterly in March, June, September and December. It is an International Journal for Biomedical Sciences. The journal publishes research papers, reviews, special article, case report, book review and letter to the editor related to Anatomy, Physiology, Biochemistry, Microbiology, Toxicology, Endocrinology, Reproductive Biology, Pharmacology and Alternative Systems of Medicines like Siddha, Unani, Ayurveda, Homeopathy and Naturopathy. Preference will be given to papers of immediate importance to other investigators, either by their experimental data, new ideas or new methodology. Scientific correspondence to the Editor-in-Chief related to the published papers may also be accepted provided that they are short and scientifically relevant to the papers mentioned, in order to provide a continuing forum for discussion.</p> <p><strong>Abstracting and Indexing</strong></p> <p>It is indexed in Excerpta Medica, Scopus, Google Scholar, Elsevier Indian Citation Index, Index Medicus, and UGC- CARE. NLM Unique ID: 8405231. Meta Data deposited in DOI and citation is tracked by crossref.</p> en-US (Prof.Manjula Shantaram) (Journal Manager) Mon, 25 Oct 2021 21:43:23 +0800 OJS 60 A TO STUDY OF THYROID PROFILE WITH ANTI-TPO, AND IRON, URIC ACID LEVELS IN PATIENTS OF MELASMA <p><strong>ABSTRACT</strong></p> <p>&nbsp;Thyroid disorders are the most common systemic disease associated with melasma. Thyroid imbalances have a probable effect on the onset of melasma. Melasma, also called ‘chloasma’, is a common skin condition of adults. Melasma is an acquired pigmentary disorder described as symmetrical blotchy or splotchy hyperpigmented macules and patches [1]</p> <p><strong>MATERIALS AND METHODS</strong>: It is a case-control observational study100 cases (76 females and 25 males) that were diagnosed with melasma are included to investigate thyroid profile, Anti TPO, with Iron, Uric acid levels are compared to control 100 subjects.</p> <p><strong>RESULTS-:</strong> Serum TSH levels were found to be higher in patients of melasma (5.1±2.53) as compared to the control population (2.59±2.66) .Serum anti TPO level was higher in (11±3.01) the patients and (9±1.46) in the controls. Serum Iron levels in cases and controls showed lower levels in patients of melasma(85±31.2) as compared to the control population (114.5±25.9) all they significant (p&lt;0.001). Mean serum T3(1.35±0.62&nbsp;&nbsp; 1)and&nbsp; FT3 (2.71±0.57) were normal&nbsp; in the case than compared the control T3 (1.41±0.76), FT3 (2.82±0.54) group. Serum T4(6.7±1.92) were higher in the case group than the control group(6.54±1.80 )but all this statistical not significant . Uric acid(3.57±0.79)and&nbsp; FT4(1.32±0.52) were higher in the case group than the control group(3.4±0.75) ,(1.22±0.48) respectively but the difference was not statistical significant.</p> <p><strong>CONCLUSION:</strong> - Thyroid profile was lower in the patients than compared to the controls but the difference was not statistically significant. Mean serum anti-TPO, FT4, and TSH, and uric acid were higher in the case group than in the control group. A possible relationship might be observed between thyroid autoimmunity and serum Iron levels in melasma.</p> <p><strong>Keywords:-</strong> Melasma, TSH thyroid-stimulating hormone, T3 Triiodothyronine, T4 thyroxine, FT3 free triiodothyronine, Free thyroxine FT4 , Anti-thyroid peroxidase (anti-TPO), serum iron, UA uric acid.</p> <p>&nbsp;</p> gayatri Copyright (c) Immunohistochemical Expression of Glycoprotein 130 (gp130) in Human Breast Carcinoma and its clinical significance. <p><strong>ABSTRACT</strong></p> <p>Glycoprotein130 (gp130) is a co-receptor associated with numerous cytokines that mediate several biological processes in breast cancer cells like proliferation, differentiation, and metastases. Glycoprotein 130 is a membrane bound receptor and plays a significant role in the Interleukin 6 mediated JAK-STAT signaling pathways. The purpose of this study is to evaluate the immunohistochemical expression of gp130 receptor in human breast carcinoma tissues and compare it with their pathological variables.</p> <p><strong>MATERIALS AND METHOD</strong></p> <p>Paraffin embedded breast cancer tissues and their adjacent normal were used in this study. Immunohistochemistry was performed for gp130 antibody, and Q score was used to measure the outcome of the tissue staining.</p> <p><strong>RESULTS</strong></p> <p>In tumor tissues, we observed a statistically significant higher Q score value when compared with adjoining normal tissues. We found a significant association between the pathological variables and the expression of gp130 receptor.</p> <p><strong>CONCLUSION</strong></p> <p>Taken collectively, the results of this study revealed that gp130 receptor could consider as a potential prognostic target.</p> Sandhya Sundaram, Krishnakumar Ramanathan Copyright (c) Stress among Medical Students and its impact on Academic Performance <p>Research Article</p> <p>&nbsp;</p> <p><strong>Stress among Medical Students and its impact on Academic Performance</strong></p> <p><strong>ABSTRACT</strong></p> <p><strong>Background: </strong>Stress is the reaction given by human body to various changes which needs physical, mental or physiological adaptation. The inordinate stress during medical education incline students to get trouble in solving social conflicts, dropped attention, reduced mindfulness, decreased in neutrality, increased errors and misconduct like negligence which leads to decrease in academic performance.</p> <p><strong>Aim and Objectives: </strong>1) To evaluate the stress prevalence in students of medical college. 2) To study the impact of stress on academic performance in students of medical college.</p> <p><strong>Materials and Methods: </strong>It was a cross sectional study which was organized by Department of Physiology, Great Eastern Medical School &amp; Hospital, Srikakulam (AP). All medical students from 2nd and 3rd MBBS were included. Students on any antipsychotic medicine &amp; not willing to participate were excluded. Informed written consent was taken from subjects The present study was conducted after approval of the Ethical Committee of Institution. Data were collected using K-10 Questionnaire for stress and academic performance.</p> <p><strong>Results: </strong>The prevalence of stress was mild, moderate and severe among 12%, 69% and 19% subjects respectively. There was a statistically significant negative association between stress and academic performance (p&lt;0.05).</p> <p><strong>Conclusion: </strong>The prevalence of stress was high among medical students. Poor academic performance is seen in students associated with higher level of stress.</p> <p><strong>Keywords: </strong>Stress, Medical-students, academic performance.</p> Dr. Pratima Khatake, Havilah Twinkle, Akshay Salgar Copyright (c) Post Covid-19 and Dentistry Revealing the silent condition - Rhino Maxillary Mucormycosis <p><strong>&nbsp;</strong></p> <p>The author would like to highlight the uncommon condition of rhinomaxillary mucormycosis which presents with a common complaint of periodontal abscess. This is highly significant in the current global scenario of the Covid-19 pandemic, as this deadly condition if diagnosed timely (by the dental surgeon) can save lives and prevent serious lifelong morbidity. Acute lung damage in Covid-19 was controlled worldwide by administering corticosteroids. This led to transient hyperglycemia, which coupled with low immunity served as an ideal environment for the fungal spore’s growth and proliferation.<sup>1</sup> Species like Candida, Aspergillus and Rhizopus are normally not virulent in healthy individuals but can cause disseminated fatal infections in an immune-compromised host.<sup>2</sup> Infection caused by these opportunistic pathogenic fungi present with non-specific symptoms and are often difficult to diagnose. Mucormycosis is the third most common opportunistic fungal infection caused by Rhizopus.<sup>3</sup> Two such cases reported to the Department of Periodontics, Maulana Azad Institute of Dental Sciences, New Delhi with similar oral findings and common history of Covid-19 recovery. Both the patients were on 3 weeks of steroid therapy during which they had transient hyperglycemia. After 4 weeks of recovery, they developed painful gum boil/s. Clinical findings revealed periodontal abscess and tooth mobility.</p> <p>&nbsp;</p> Anju Rana, Shruti Tandon, Arundeep Kaur, Farrukh Faraz, Kamal Agarwal Copyright (c) 2021 Mon, 25 Oct 2021 00:00:00 +0800 ANCA Associated vasculitis- A case of microscopic polyangiitis with proliferative glomerulonephritis <p><strong>Antineutrophil cytoplasmic&nbsp;antibody&nbsp;(ANCA)-associated vasculitis (AAV)&nbsp;</strong>are a collection of diseases,<strong>&nbsp;</strong>characterised by destruction and inflammation of small and medium vessels.&nbsp;Microscopic Polyangiitis (MPA) is part of an ANCA-associated vasculitis (AAV).The clinical signs diverge and disturba number of&nbsp;organs such as the kidneys, lungs, stomach and intestine. Skin manifestations such as&nbsp;<a href="">purpuric</a>, <a href="">urticaria</a>l, nodular, ulcerative, livedoid and necrotic skin lesions were common as in other vaso-occlusive disorder. Morphology and added features aid the diagnostic approach. Here, we report a diagnostically challenging case of microscopic polyangiitis with progressive glomerulonephritis.</p> R.C. Akshaya, R. Sathyanarayanan , C.R.V. Narasimhalu, Sonti Sulochana Copyright (c) 2021 Mon, 25 Oct 2021 00:00:00 +0800