Biomedicine

Abstract

Diabetes is a well-known chronic disorder of metabolic origin that involves hyperglycaemia. It is said to affect around 451 million people all around the world. At current situation, this condition is found to be the leading cause of death due to complications associated with it. It ranges from neuropathy to nephropathy. The major mechanism behind this was found to be oxidative stress that is caused by rise of reactive oxygen species (ROS) and defective antioxidant defense mechanism. To encounter this problem, antioxidants are being used as a therapy to target this problem of oxidative stress as a potential adjunctive treatment in diabetes. The current article explores the concept of targeted, novel formulation of antioxidant combination designed specifically to alleviate diabetes-associated oxidative stress, thereby delivering an effective solution to prevent development of complications and to enhance the patient outcomes. Simultaneously, while managing the glucose metabolism it is crucial to regulate and mitigate the ongoing oxidative stress in diabetes to prevent the complications. Hence, development of a scientifically refined and potent antioxidant combination that could powerfully neutralize the oxidative stress is timely and necessary. The proposed combination of antioxidants for diabetes comprises of Alpha-Lipoic Acid, N-Acetylcysteine, Curcumin, Vitamin E and Resveratrol. At present, this novel antioxidant formulation is a theoretical gem that needs real-world polish. The further steps should include laboratory testing and trials to confirm the efficacy, bioavailability variability, stability, dosage and safety of this novel combination.