Biomedicine

Abstract

Introduction: Hypothyroidism a common endocrine disorder has been linked to alterations in iron metabolism. Changes in iron metabolism and its deficiency may impair thyroid hormone production.The present study aimed to estimate serum iron profile among hypothyroid patients. Materials and Methods: This cross-sectional study was conducted at Jawaharlal Nehru Institute Of Medical Sciences, Imphal, during the period from March 2023 to Febuary 2025. Ethical approval was taken from the institutional Ethics Committee JNIMS, Imphal. The Serum Iron and Serum TIBC were measured using Automated photometric systems on Diasys Sys 200 Pro. Serum Ferritin by ELISA method. This study consists of 192 lab-diagnosed hypothyroid cases based on the thyroid profile. Data was analyzed by using SPSS v22. Results: Among total 192 study subject’s majority 41.15% of them were in the age group 31-40 years. Mean TSH level in males (16.79 ± 21.79) was significantly higher than in females (10.45 ± 7.89), with a p-value of 0.005.There was statistically significant positive correlation between TSH and TIBC (r = 0.433, p < 0.001) and while statistically negative correlation between TSH and ferritin and between TSH and serum iron (p < 0.001). Conclusion: The correlation analysis reveals that as TSH levels increase, serum ferritin and iron levels decrease while TIBC increases, indicates an association between hypothyroidism and iron deficiency. This highlights the importance of monitoring iron status in individuals with hypothyroid and to ensure timely diagnosis and management of disease outcome.