Biomedicine

Abstract

A promising area for the creation of cutting-edge treatments to deal with organ/tissue failure is regenerative medicine. In contrast to other methods, 3D bioprinting has drawn a lot of interest since it can create intricate structures with exact cell placement and composition. A thorough assessment of current developments in 3D bioprinting technologies for tissue/organ engineering and in vitro models is the goal of this review. The study includes a thorough investigation and evaluation of pertinent papers released between 2015 and 2023. The review discusses developments in cell sources, biomaterials, bioinks, bioprinting methods, and post-printing maturation processes. The results show important advancements in the creation of bioinks that mirror the microenvironments of natural tissue, enabling improved cell survival, differentiation, and tissue performance. Complex tissue architectures with vasculature and heterogeneity may now be created using novel bioprinting techniques including multi-material and multimodal printing. Furthermore, the development and improvement of in vitro models for disease modeling, drug screening, and personalized medicine have been made easier by the integration of modern imaging and computer modeling approaches. This comprehensive analysis shows how 3D bioprinting technology has advanced recently and highlights how it has the potential to transform in vitro models and regenerative medicine. The results help us comprehend the difficulties, possibilities, and potential paths in this quickly developing sector.