Volume: 43 Issue: 2
Year: 2023, Page: 701-705, Doi: https://doi.org/10.51248/.v43i02.2517
Introduction and Aim: Fine needle aspiration cytology (FNAC), is a frequently employed diagnostic procedure in identifying lymph node pathology. This study aims to categorise cytological aspirates from lymph nodes according to the Sydney system and in addition determine the likelihood of cancer occurrence in the classified categories.
Materials and Methods: A cross-sectional study analysing lymph node cytology was performed retrospectively between January 2021 to December 2022, and the findings were classified into five groups from L1 to L5 as proposed by the Sydney System. By comparing the diagnoses with the corresponding histological diagnosis, statistical analysis was used to evaluate the probability of malignancy linked with each group.
Results: Out of 279 fine needle aspiration cytology (FNAC) tests performed for lymphadenopathy, 39 cases were compared with histopathological results. The cases classified to the categories L1, L2, L3, L4, and L5 were 11/279 (3.9%), 170/279 (60%), 2/279 (0.7%), and 93/279 (33%) accordingly. The likelihood of developing cancer was found to be 33.33%, 8.8%, 56.4%, 83.33%, and 94.74% for each group.
Conclusion: To achieve uniformity and repeatability in cytopathological diagnosis, the recommended Sydney method of lymph node cytology reporting and classification can be effective
Keywords: Cytology; lymph node; likelihood of cancer
1. Pambuccian, S.E., Bardales, R.H. Overview of ancillary methods in lymph node FNA diagnosis. Lymph node cytopathology. Essentials in Cytopathology. Springer, Boston. 2011;10: 9-11.
2. Gupta, P., Gupta, N., Kumar, P., Bhardwaj, S., Srinivas, R., Dey, P., et al., Assessment of risk of malignancy by application of the proposed Sydney system for classification and reporting lymph node cytopathology. Cancer Cytopathology 2021;129(9):701-718.
3. Vigliar, E., Acanfora, G., Iaccarino, A., Mascolo, M., Russo, D., Scalia, G., et al., A novel approach to classification and reporting of lymph node fine needle cytology: Application of the proposed Sydney system. Diagnostics 2021;11(8): 1314.
4. Abbadi, M.A., Barroca, H., Bode, L.B., Calaminici, M., Caraway, N.P., Chhieng, D.F., et al., A proposal for the performance, classification and reporting of lymph node fine needle aspiration cytopathology: The Sydney system. Acta Cytologica 2020; 64(4):306-322.
5. Zeppa, P. Haematocytopathology: why? Cytopathology 2012 23: 73-75.
6. Wilkinson, A., Mahore, S., Maimoon, S. FNAC in the diagnosis of lymph node malignancies: A simple and sensitive tool. Indian J Med Paediatr Oncol 2012;33(1):21-24.
7. Baruah, A. K., Bhuyan, G. Utility of the Sydney system for reporting of lymph node cytology in a tertiary health care set up of north-eastern India. World cancer research journal. 2022; 9: e2459.
8. Ahuja, S., Malviya, A. Categorisation of lymph node aspirates using the proposed Sydney system with assessment of risk of malignancy and diagnostic accuracy. Cytopathology. 2022; 33(4): 430-438.
9. Caputo, A., Ciliberti, V., D’Antonia, A., D’Ardia, A., Fumc, R., Giudice, V., et al., Real-world experience with the Sydney system on 1458 cases of lymph node fine needle aspiration cytology. Cytopathology. 2022; 33(2): 166-175.
Ankita Shibu Robert, Crysle Saldanha. An approach to classification and reporting lymph node cytopathology using Sydney system and evaluating the likelihood of malignancy. Biomedicine: 2023; 43(2): 701-705