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Biomedicine

Volume: 39 Issue: 3

  • Open Access
  • Original Article

Anti-proliferative effect of Oyster mushroom, Pleurotus from Florida (misnomer) P. florida (Agaricomycetes) against HeLa and SIHA cervical cancer cells: Mushroom-boon for cancer therapies

Ravi Kant Pathak1, Deepika Singh2, Krishna Kumar Gupta1, Shweta Maurya1

1Centre of Biotechnology, Institute of Interdisciplinary Studies (IIDS) University of Allahabad, Prayagraj -211002, India
2Molecular Human Genetics, Institute of Science, Banaras Hindu University, Varanasi-221005 India

Corresponding author: Ravi Kant Pathak. Email: [email protected]

Year: 2019, Page: 491-496, Doi: https://doi.org/10.51248/v39i3.22

Abstract

Introduction and Aim: Worldwide, people are suffering from the increased risk of cancer due to change in lifestyle, feeding habit and quality of food. To overcome this global problem, Mushroom act as a magic wand. The recent investigations reveal that cancer prevalence is inversely proportional to the intake of mushroom; this is because of its proteins, vitamins, carbohydrate and antioxidants contents.
Materials and Methods: Among various species of mushrooms, Pleurotus mushrooms are considered as nutraceuticals i.e. it has nutritional and medicinal values. However, mushroom products and extracts possess immunomodulating and direct cytotoxic effect on cancer cells.
Results: The results from the present study shows the potential cytotoxic effect of Pleurotus from Florida against cervical cancer (SIHA) cell line through apoptosis. When SIHA cells were incubated with varying concentration of methanolic extract of Pleurotus from Florida for time (48 hrs). The MTT assay revealed the cytotoxic activity of MME of Pleurotus from Florida in a dose dependent manner. The cell cycle analysis of the SIHA cells revealed that MME of Pleurotus from Florida have anti-cancerous activity.
Conclusion: The study could be concluded as the Pleurotus from Florida extract can be useful in the treatment of cervical cancers. The chemical compounds present in the P. from Florida might be useful in the development of drug for the treatment of cancer patients.

Keywords: Oyster mushroom; Pleurotus; methanolic extract; SIHA cells; HeLa cells; cytotoxic effect; propidium iodide; medicinal mushroom.

Cite this article

Ravi Kant Pathak, Deepika Singh, Krishna Kumar Gupta, Shweta Maurya. Anti-proliferative effect of Oyster mushroom, Pleurotus from Florida (misnomer) P. florida (Agaricomycetes) against HeLa and SIHA cervical cancer cells: Mushroom-boon for cancer therapies. Biomedicine: 2019; 39(3): 491- 496

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