Biomedicine

Abstract

Introduction and Aim: Anxiety is the common psychiatric condition. This study was done to screen anti- anxiety activity of hydroalcoholic extract of Aegle marmelos (HAAM) fruit in Swiss albino mice. Materials and Methods: 100 mg/kg and 200mg/kg extracts of Aegle marmelos fruit and a combination of 200 mg/kg extract and diazepam were compared with the Diazepam 1mg/kg and distilled water. Each group consisted of six Swiss albino mice. Anxiety was evaluated using the models Elevated Plus Maze (EPM) and Light Dark Arena (LDA). Time spent in open and closed arm in EPM and time spent in bright and dark area in LDA were calculated. Data was analysed by one -way ANOVA followed by Tukey Kramer’s test. Results: HAAM 200 mg/kg plus diazepam group has high value when compared with the control, standard, HAAM 100 mg and HAAM 200 mg. HAAM 200 had anxiolytic effect when compared to the standard. When HAAM 200 mg + diazepam was given, time spent in the light box and open arm was more and was found to be statistically significant when compared to control and standard. Two doses 100 mg and 200 mg has anxiolytic properties when compared to the control and standard. The combination of hydroalcoholic extract of Aegle marmelos (HAAM) 200 mg with the diazepam has also showed a significant anxiolytic effect when compared to the standard and control. Conclusion: The result confirms anti-anxiety properties of Aegle Marmelos fruit. Hence Aegle marmelos fruit may be used as a promising agent for the treatment of anxiety.