Biomedicine

Abstract

Background and Aims: Cirrhosis of the liver, a complex and progressive condition, can manifest beyond hepatic dysfunction, potentially affecting pulmonary function. This study aimed to investigate the association between liver cirrhosis severity, as assessed by Child-Pugh scores, and pulmonary manifestations. Clinical parameters were also examined for potential correlations.
Materials and Methods: A cross-sectional study included 100 patients with cirrhosis aged 48.80 ± 13.91 years. Symptom prevalence, varices grades, viral markers, arterial blood gas, pulmonary function, and Child-Pugh classes were assessed. Statistical analysis, including correlation coefficients, regression models, and p-values, was performed using SPSS.
Results: Splenomegaly (98%), Ascites (95%), and abdominal distension (75%) were common symptoms. Varices were observed in 69% of patients. 41% were in Child-Pugh class B, 32% in class C, and 27% in class A. Arterial blood gas abnormalities were noted in 8% of patients. Obstructive pulmonary function was present in 2%, while 25% exhibited restrictive patterns. Severity of liver disease was significantly associated with pulmonary function, with FEV1/FVC ratio reflecting this association (P<0.05).
Conclusion: This study demonstrates a significant link between liver cirrhosis severity and pulmonary manifestations, highlighting potential systemic connections. Arterial blood gas findings may suggest preserved pulmonary gas exchange despite advanced cirrhosis. The FEV1/FVC ratio's correlation with liver disease severity suggests a potential interplay between hepatic dysfunction and altered pulmonary mechanics. Further investigations are warranted to comprehend the complex interactions between liver and pulmonary systems in patients with cirrhosis. "