Biomedicine

Abstract

Introduction and Aim: The use of intrathecal adjuvants extends the block's duration, resulting in a higher success rate and increased patient satisfaction. Additionally, it offers acceptable pain control. Dexmedetomidine may be utilized as an epidural adjuvant with local anesthetic sparing properties. In the same way, magnesium's ability to block the NMDA receptor and calcium channel is crucial for anesthesia. The goal of this study was to determine the optimal combination of dexmedetomidine, ropivacaine, and magnesium sulfate for spinal anesthesia during infraumbilical surgeries. Materials and methods: Seventy-two participants undergoing infraumbilical surgeries under spinal anesthesia aged between 21 and 60 years were considered. We randomly assigned participants to two groups: DR (isobaric ropivacaine hydrochloride (0.75%) with 10g of dexmedetomidine in 0.5 ml of normal saline) and MR (isobaric ropivacaine (0.75%) with 75 mg of magnesium Sulfate in 0.5 ml of normal saline). Results: The mean onset duration, total duration of motor block, and total duration of analgesia were statistically significant (p<0.05). The mean heart rate, systolic blood pressure, and diastolic blood pressure were statistically not significant from the beginning to the end of the study (p > 0.05). Conclusion: Compared to magnesium Sulfate, dexmedetomidine is a more effective adjunct to intrathecally administered ropivacaine in infraumbilical surgeries.