Biomedicine

Abstract

Introduction and Aim: Nosocomial bacterial infections have reached an alarming state in the healthcare system. Majority of the morbidity and mortality in burn patients are caused by microbial infections, particularly those brought on by multidrug-resistant (MDR) organisms, including methicillin-resistant Staphylococcus aureus (MRSA). This study aimed to investigate microbiological diversity among burn patients and their antibiotic susceptibility profiles at SUM hospital, Odisha, India. Methodology: This prospective analysis was carried out from 2023 to 2024 on burn patients who were admitted to intensive care units/burn wards owing to either industrial or domestic accidents. Numerous variables were included for data collection such as the extent of burns, clinical and demographic data, laboratory results and treatment details. The data was analysed using various statistical tools. Results: It was determined that a total of 741 isolates were collected from 181 hospitalized burn patients with total body burnt surface area of 29.6%. The predominant microbes found were Pseudomonas aeruginosa (88.63% of 741) followed by Klebsiella pneumoniae (67.04%; of 741 ) and Acinetobacter baumannii with 62.50% in male patients, while in female patients the Pseudomonas aeruginosa and Klebsiella pneumoniae were found as 84.94% followed by Acinetobacter baumannii with 58.06%. There were 24 different type of bacterial isolates and 5 fungal isolates found in both the genders across various age groups. Conclusions: The occurrence of microbial infection was more often in male patients than females, while multidrug resistance microbial infection was more common among female patients than males. The pattern of infection acceleration was observed in positive correlation with patients total body surface area (TBSA) and prolonged hospital stay.