Volume: 43 Issue: 3
Year: 2023, Page: 893-896, Doi: https://doi.org/10.51248/.v43i3.2823
Introduction and Aim: Polycystic ovarian syndrome (PCOS) is characterized by chronic anovulation and hyperandrogenism. PCOS also affects thyroid hormones, with multiple studies showing a link between autoimmune thyroid disease (AITD) and polycystic ovarian syndrome, although the exact pathophysiology of this interaction remains unknown. In this study the autoimmune thyroid indicators in women with PCOS were examined in order to demonstrate a link between polycystic ovarian syndrome and autoimmune thyroid disease.
Materials and Methods: The study included 85 polycystic ovarian syndrome (PCOS) patients and 50 controls with similar ages. Thyroid autoantibodies (anti-thyroglobulin (Anti-Tg) and anti-peroxidase (anti-TPO), thyroid hormones (free thyroxine (T4), triiodothyronine (T3), and thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH) were determined in both study groups of women.
Results: In women with polycystic ovarian syndrome (PCOS) the blood levels of anti-thyroid peroxidase antibody (anti-TPO), antithyroglobulin antibody (anti-TG)) and thyroid stimulating hormone (TSH) were higher than women without PCOS. However, no difference was observed for free thyroxine (FT4) levels among PCOS and no PCOS women.
Conclusion: Thyroid dysfunction and thyroid autoimmunity was found to be linked in women with PCOS.
Keywords: Polycystic ovarian syndrome; Autoimmune thyroid disease; Antithyroglobulin antibody.
1. Yildiz, B. O., Bozdag, G., Yapici, Z., Esinler, I., Yarali, H. Prevalence, phenotype and cardiometabolic risk of polycystic ovary syndrome under different diagnostic criteria. Human reproduction. 2012; 27(10): 3067-3073.
2. Swathi, A., Reddy, Y. Effect of Metformin therapy on lipid profile in obese and non-obese women with polycystic ovarian syndrome (PCOS). Biomedicine. 2022 Mar 5;42(1):134-137.
3. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Hum Reprod. 2004; 19(1):41-47.
4. Dev, D., Dutta, P. A novel approach to treat polycystic ovarian syndrome (PCOS) patients. Biomedicine. 2022 Sep 12;42(4):841-843.
5. GulabKanwar, D., Jain, D. N., Shekawat, D. M., Sharma, D. N. Estimation of LH, FSH, prolactin and TSH levels in polycystic ovarian syndrome and correlation of LH and FSH with serum TSH levels. IOSR Journal of Dental and Medical Sciences. 2015; 14(5): 64-68.
6. Mykhalchenko, K., Lizneva, D., Trofimova, T., Walker, W., Suturina, L., Diamond, M. P., et al., Genetics of polycystic ovary syndrome. Expert review of molecular diagnostics. 2017; 17(7): 723-733.
7. Lavanya, K., Palaniappan, N., Vinodhini, V.M., Kumar, M., Silambanan, S. Association of prolactin and insulin with obesity in women with polycystic ovarian syndrome. Biomedicine. 2022 Dec 31;42(6):1166-1171.
8. Hefler-Frischmuth, K., Walch, K., Huebl, W., Baumuehlner, K., Tempfer, C., Hefler, L. Serologic markers of auto-immunity in women with polycystic ovary syndrome. Fertility and sterility 2010; 93(7): 2291-2294.
9. Poppe, K., Glinoer, D., Van Steirteghem, A., Tournaye, H., Devroey, P., Schiettecatte, J., et al., Thyroid dysfunction and autoimmunity in infertile women. Thyroid, 2002, 12.11: 997-1001.
10. Veena Kirthika, S., Paul, J., Senthil Selvam, P., Sathya Priya, V., 2019. Effect of progressive resisted exercises and aerobic exercises in the management of polycystic ovarian syndrome among young women-A pilot randomized controlled trial
2019;39(4):608-612.
11. Saran, S., Gupta, B. S., Philip, R., Singh, K. S., Bende, S. A., Agroiya, P. et al., Effect of hypothyroidism on female reproductive hormones. Indian journal of endocrinology and metabolism. 2016; 20 (1): 108.
12. Janssen, O. E., Mehlmauer, N., Hahn, S., Offner, A. H., Gartner, R. High prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome. European journal of endocrinology. 2004; 150 (3): 363-370.
13. Ho, C. W., Chen, H. H., Hsieh, M. C., Chen, C. C., Hsu, S. P., Yip, H. T., et al., Increased risk of polycystic ovary syndrome and its comorbidities in women with autoimmune thyroid disease. International journal of environmental research and public health. 2020; 17(7): 2422.
14. Kennedy, R. L., Malabu, U. H., Jarrod, G., Nigam, P., Kannan, K., Rane, A. Thyroid function and pregnancy: before, during and beyond. Journal of Obstetrics and Gynaecology. 2010; 30(8): 774-783.
15. Makled, A. K., Fathi, H. M., Gomaa, M. F., Bakr, R. M. Serologic markers of autoimmunity in women with polycystic ovary syndrome. Middle East Fertility Society Journal. 2015; 20(2): 86-90.
16. Karakose, M., Hepsen, S., Cakal, E., Arslan, M. S., Tutal, E., Akin, S. et al., Frequency of nodular goiter and autoimmune thyroid disease and association of these disorders with insulin resistance in polycystic ovary syndrome. Journal of the Turkish German Gynecological Association. 2017; 18(2): 85.
17. Singla, R., Gupta, Y., Khemani, M., Aggarwal, S. Thyroid disorders and polycystic ovary syndrome: An emerging relationship. Indian journal of endocrinology and metabolism. 2015; 19 (1): 25.
18. Begum, S., Hossain, M. Z., Rahman, M. F., Banu, L. A. Polycystic ovarian syndrome in women with acne. Journal of Pakistan Association of Dermatologists. 2012; 22(1): 24-29.
19. Pushpagiri, N., Gracelyn, L. J., Nagalingam, S. Prevalence of subclinical and overt hypothyroidism in infertile women. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2015;4(6): 1733-1739.
20. Du, D., Li, X. The relationship between thyroiditis and polycystic ovary syndrome: a meta-analysis. International Journal of Clinical and Experimental Medicine. 2013; 6(10): 880.
21. Sinha, U., Sinharay, K., Saha, S., Longkumer, T. A., Baul, S. N., Pal, S. K. Thyroid disorders in polycystic ovarian syndrome subjects: A tertiary hospital based cross-sectional study from Eastern India. Indian journal of endocrinology and metabolism. 2013;17(2): 304.
22. Ganie, M. A., Kalra, S. Polycystic ovary syndrome–A metabolic malady, the mother of all lifestyle disorders in women–Can the Indian health budget tackle it in future? Indian Journal of Endocrinology and Metabolism. 2011; 15(4): 239.
23. Al-Saab, R., Haddad, S. Detection of thyroid autoimmunity markers in euthyroid women with polycystic ovary syndrome: a case-control study from Syria. International Journal of Endocrinology and Metabolism. 2014;12(3).
24. Kachuei, M., Jafari, F., Kachuei, A., Keshteli, A. H. Prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome. Archives of Gynecology and Obstetrics. 2012; 285(3): 853-856.
25. Petrikova, J., Lazurova, I.,Yehuda, S. Polycystic ovary syndrome and autoimmunity. European Journal of Internal Medicine. 2010; 21(5): 369-371.
26. Klecha, A. J., Arcos, M. L. B., Frick, L., Genaro, A. M., Cremaschi, G. Immune-endocrine interactions in autoimmune thyroid diseases. Neuroimmunomodulation. 2008; 15(1): 68-75.
27. Quintero, O. L., Amador-Patarroyo, M. J., Montoya-Ortiz, G., Rojas-Villarraga, A., Anaya, J. M. Autoimmune disease, and gender: plausible mechanisms for the female predominance of autoimmunity. Journal of Autoimmunity. 2012; 38(2-3): J109-J119. 28. Gaberscek, S., Zaletel, K., Schwetz, V., Pieber, T., Obermayer-Pietsch, B., Lerchbaum, E. Thyroid and polycystic ovary syndrome. Endocrinology. 2015;172(1): R9- R21.
Shaimaa Awadh Auda, Eqbal Awadh Gatea, Zainab Awaad Radhi. Evaluation of thyroid autoimmunity markers in polycystic ovarian syndrome in women. Biomedicine: 2023; 43(3): 893-896