Volume: 44 Issue: 2
Year: 2024, Page: 204-215, Doi: https://doi.org/10.51248/v44i2.24
Received: May 7, 2024 Accepted: June 13, 2024 Published: June 18, 2024
INTRODUCTION: Inflammation is recognized as a triggering factor of the initiation and progression of neoplastic processes. Neutrophilia and lymphopenia are hallmarks of inflammation. The aim of this study is to correlate pretreatment value of neutrophil lymphocyte ratio [NLR] as prognostic factor in breast cancer.
MATERIALS & METHODS: Data of biopsy proven cases of breast cancer were analysed retrospectively. Pearson correlation test was used to correlate NLR with stage, luminal subtypes and IHC markers of breast cancer. The cut off values of NLR were calculated using median and ROC curve analysis.
Results: 742 patients out of 1275 patients were eligible for study. Median age was 47 years (mean ± sd 47.67 ± 10.63 years). 43.1% patients are of Luminal A type, 7.1 % are Luminal B type, 11.9% are HER 2 neu enriched and 37.9% are TNBC. Median follow up time for study was 53 months.NLR median value is 2.14 (0.52 to 15). Median value of NLR 2.14 was used as cutoff into high (>2.14) and low (< 2.14)arms. Statistically significant association was found in high NLR and HER 2 neu positive patients and patients with high ki67%. The median DFS in high NLR (> 2.1) was 82 months (95% CI 79.143, 84.847). Median DFS was not reached in the low NLR arm.
CONCLUSION: High neutrophil count and high NLR is strongly associated with poor survival of breast cancer patients.This can be used as predictive and prognostic factor. "
Keywords: Breast cancer, NLR, overall survival, DFS
Sumana Maiti Das, Krishnangshu Bhanja Choudhury, Oona Chakrabarty, Sanskriti Poddar, Partha Dasgupta, Siddhartha Das. Impact of Neutrophil Lymphocyte Ratio on Tumour Parameters and Overall Survival in patients of Breast Cancer: A Single Institutional Retrospective Audit. Biomedicine: 2024; 44(2):204-215.