Limitation of Estimating Glycosylated Hemoglobin to diagnose Diabetes Mellitus in a case of Spherocytosis

Volume: 45 Issue: 4

Open Access
Case Report

Limitation of Estimating Glycosylated Hemoglobin to diagnose Diabetes Mellitus in a case of Spherocytosis

Siddhartha Gupta¹, Sabyasachi Ghorai², Soma Gupta^3*

¹Micro Clinical Laboratory & Diagnostic Centre, Haldia, Purba Medinipur and Department of Biochemistry, ICARE Institute of Medical Sciences and Research and Dr. Bidhan Chandra Roy Hospital, Haldia, Purba Medinipur West Bengal, India
²Department of Pathology, Micro Clinical Laboratory & Diagnostic Centre, Haldia, Purba Medinipur, West Bengal, India
³Department of Biochemistry, Midnapore Medical College, Paschim Medinipur, West Bengal, India

*Corresponding Author:
Soma Gupta
Email: [email protected]

Year: 2025, Page: 343-346, Doi: https://doi.org/10.51248/v45i4.173

Received: July 24, 2025 Accepted: Nov. 12, 2025 Published: Nov. 23, 2025

Abstract

Here we report identification of a case of spherocytosis, which is peculiar in the sense that detection was done due to mismatch of blood glucose and HbA1c level. The stepwise identification is discussed in detail. It is also recommended that monitoring of patients with Diabetes mellitus should not be done by estimation of Hb A1c level, if the patient is suffering from spherocytosis at the same time. In such case, estimation of glycosylated pre-albumin and fructosamine may be helpful.

Keywords: Glycosylated Hemoglobin, Spherocytosis, Monitoring, Diabetes, Mellitus

Cite this article

Siddhartha Gupta, Sabyasachi Ghorai, Soma Gupta. Limitation of Estimating Glycosylated Hemoglobin to diagnose Diabetes Mellitus in a case of Spherocytosis. Biomedicine: 2025, 45(4):343-346

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