Volume: 43 Issue: 3
Year: 2023, Page: 1051-1055, Doi: https://doi.org/10.51248/.v43i3.2135
Introduction and Aim: Anaemia is the most common deficiency disorder among people of all age groups, known as Paandu in the Siddha system of medicine. The test drug siddha poly mineral formulation Lavana Dravagam mentioned in Siddha literature kannukamiyam ennum vaithiya segaram, has been used for pandu (anaemia). Dravagam is a form of internal medicine, processed by distillation method and is also referred as Pugai neer, Shakthi neer, Dravaga neer. The study aimed to evaluate the haematinic activity and efficacy of poly mineral Siddha formulation Lavana Dravagam against phenylhydrazine induced anaemic albino Wistar rat model.
Materials and Methods: The animals were selected and divided into four groups (I, II, III, and IV) of six rats (n=6) each. Anaemia was induced by an oral administration of phenylhydrazine (single dose of 10 mg/kg per oral for 8 days). Group I served as normal control and Group II received standard drug hematinic syrup in suspension form at dose 2 mL/kg. Groups III, IV received the formulated oral indiffusible mixture of Lavana Dravagam at a dose of 0.02ml to 0.03ml/kg respectively. RBC, Hb, PCV, MCV, MCH, were analyzed as indices of anaemia. The mean corpuscular volume, mean corpuscular Hb, and mean corpuscular Hb concentration were calculated.
Results: From the literature evidence, acute toxicity evaluation and pharmacological studies, the drug Lavana Dravagam is found out to have hematinic activity. This study reveals that there is significant (P<0.05) increase in RBC count, Hb level, and PCV by administering phenylhydrazine within one week of treatment.
Conclusion: It could be concluded that the drug Lavana dravagam will have promising effects in the management of anaemia (Paandu).
Keywords: Distillation; Lavana Dravagam; Siddha formulation; Paandu (anaemia).
1. Princess, S.S., Dayanand, R.G., Muthuvel, A. A safety profile of Siddha formulation Karisalai Chooranam in Wistar albino rats. Biomedicine. 2023 May 26;43(02):779-784.
2. Uthamarayan, C.S. A compendium of siddha doctrine, Directorate of Indian Medicine and Homeopathy; First Edition, 2005.
3. Ogbe, R.J., Aduga, G.I., Abu, A.H. Antianemic potentials of
some plant extracts on phenylhydrazine induced anaemia in rabbits. J Medicinal Plants Res. 2010; 4: 680-684.
4. Waugh, A., Grant, A. Ross, W. Anatomy and physiology in health and illness. UK: Elsevier Churchill Livingstone. 2006.
5. Benoist, B., McLean, E., Cogswell, M., Egli, I., Wojdyla, D. Worldwide prevalence of anaemia, WHO Global database on anaemia World Health Organization. Geneva. 2008.
6. Tortora, G.J., Derrickson, B.H. Principles of anatomy and physiology. NJ: John Wiley and Sons. 2009.
7. Ramu, S., Murthy, S.K., Krishna, S., Somashekhariah, A.L., Nandihalli, V.B., Muzammil, K.M. Preclinical evaluation of the haematinic activity of an oral indiffusible mixture of Tamarindus indica L., leaf extract, Turk J Pharm Sci 2019;16 (1):27-31.
8. Kaur, K. Anaemia ‘a silent killer’ among women in India: Present scenario. European Journal of Zoological Research. 2014; 3(1):32-36.
9. Mehdi, E., Sady, H. Prevalence and risk factors of iron deficiency anaemia. American Journal of Health Research, 2014, 2(5):319-326.
10. Rajarathinam, J., Abel, R., Asokar, J.S. Prevalence of anaemia among adolescent girls in rural Tamil Nadu. Indian Paediatrics, 2013; 37: 532-536.
11. Pillai, K. S. Kannusamy Ennum Vaithiya Segaram page 158.
12. Thiyagarajan, R. Gunapadam –II and III part – Thathujeeva vaguppu, 9th Edition, Indian Medicine and Homeopathy Dept., Chennai.
13. Ghosh, M.N. Toxicity studies. Fundamentals of Experimental Pharmacology. 2nd ed. Calcutta: SC and RC Book Agencies; 1984. p.154.
14. Mir, A.H., Sexena, M., Malla, M.Y. An acute oral toxicity study of methanolic extract from Tridex procumbens in Sprague Dawley’s rats as per OECD guidelines 423. Asian J Plant Sci Res 2013;3(1):16-20.
15. Yavanarani, S., Selvakumar, R., Sathiyabama, M. Preclinical toxicological screening of Siddha medicine Ganthi Mezhugu by acute toxicity studies in Wistar albino rats. Biomedicine. 2023 Mar 28;43(01):348-352.
16. Madhavan, R., Muthukumar, N.J., Sagayam, C.S., Davidraj, C., Sriram, S., Perumal, R., Brindha, P. Studies on the safety profiles of a Siddha preparation-Thirithodamathirai. Biomedicine. 2022 Jul 3;42(3):605-611.
17. Narayanaswami, V., Uthamarayan, C. S. Formulary of siddha medicines; The Indian Medical Practitioners Co-Operative Pharmacy and Stores Ltd. Third Edition ;1989
18. Ramalingayya, M., Sastry, V. Vaidya Yoga Ratnavali (Formulary of Ayurvedic Medicines). The Indian Medical Practitioners Co-Operative Pharmacy and Stores Ltd, Adayar, Madras; 1968.
19. Nadkarni, K. M. Indian Materia Medica. Popular Prakashan. Volume 2. Third Edition; 2005.
20. Wiedmann, T, S., Naqwi. A. Pharmaceutical salts: Theory, use in solid dosage forms and in situ preparation in an aerosol. Asian Journal of Pharmaceutical Sciences. 2016; 2(6):722-734.
21. Muthailyar, K. Textbook of Vaithiya saarasangiragam Aathma ratchamirtham, B. Rathnanyagar, Thirumal achagam. 1968.
22. Naidu, T.K. Textbook of Agasthiyar Vaithiya Paripooranam. Gurusamy Konar. 2nd edition; 1956.
23. Nair, V. S. A review on theeneer and dravagam (distillates) used in Siddha medicine and their biomedical application in chemistry and healthcare system. International Journal of Medical Research and Pharmaceutical Sciences. 2017;4(10): 32-48.
Jeeva S., Kesavarajan S., Mariappan A., S. Sundar, Meenakaumari R., Radha Sudalaimani. Pharmacological evaluation for haematinic activity of Siddha formulation Lavana Dravagam in rat model. Biomedicine: 2023; 43(3): 1051-1055